{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:12:12Z","timestamp":1774627932127,"version":"3.50.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Overseas Researchers","award":["16F16419"],"award-info":[{"award-number":["16F16419"]}]},{"name":"Scientific Research on Innovative Areas"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP18H05435"],"award-info":[{"award-number":["JP18H05435"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously identified quantitative trait loci (QTL) for prepulse inhibition (PPI), an endophenotype of schizophrenia, on mouse chromosome 10 and reported Fabp7 as a candidate gene from an analysis of F2 mice from inbred strains with high (C57BL\/6N; B6) and low (C3H\/HeN; C3H) PPI levels. Here, we reanalyzed the previously reported QTLs with increased marker density. The highest logarithm of odds score (26.66) peaked at a synonymous coding and splice-site variant, c.753G&amp;gt;A (rs257098870), in the Cdh23 gene on chromosome 10; the c.753G (C3H) allele showed a PPI-lowering effect. Bayesian multiple QTL mapping also supported the same variant with a posterior probability of 1. Thus, we engineered the c.753G (C3H) allele into the B6 genetic background, which led to dampened PPI. We also revealed an e-QTL (expression QTL) effect imparted by the c.753G&amp;gt;A variant for the Cdh23 expression in the brain. In a human study, a homologous variant (c.753G&amp;gt;A; rs769896655) in CDH23 showed a nominally significant enrichment in individuals with schizophrenia. We also identified multiple potentially deleterious CDH23 variants in individuals with schizophrenia. Collectively, the present study reveals a PPI-regulating Cdh23 variant and a possible contribution of CDH23 to schizophrenia susceptibility.<\/jats:p>","DOI":"10.1093\/schbul\/sbab007","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T03:59:50Z","timestamp":1610596790000},"page":"1190-1200","source":"Crossref","is-referenced-by-count":17,"title":["Role of an Atypical Cadherin Gene,\n                    <i>Cdh23<\/i>\n                    in Prepulse Inhibition, and Implication of\n                    <i>CDH23<\/i>\n                    in Schizophrenia"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1098-1290","authenticated-orcid":false,"given":"Shabeesh","family":"Balan","sequence":"first","affiliation":[{"name":"Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan"},{"name":"Neuroscience Research Laboratory, Institute of Mental Health and Neurosciences (IMHANS), Kozhikode, 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