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It is an open question whether multivariable models could be developed to predict remission outcomes at the same level of performance and generalizability as those that predict conversion to psychosis. Participants were drawn from the North American Prodrome Longitudinal Study (NAPLS3). An empirically derived set of clinical and demographic predictor variables were selected with elastic net regularization and were included in a gradient boosting machine algorithm to predict prodromal symptom remission. The predictive model was tested in a comparably sized independent sample (NAPLS2). The classification algorithm developed in NAPLS3 achieved an area under the curve of 0.66 (0.60\u20130.72) with a sensitivity of 0.68 and specificity of 0.53 when tested in an independent external sample (NAPLS2). Overall, future remitters had lower baseline prodromal symptoms than nonremitters. This study is the first to use a data-driven machine-learning approach to assess clinical and demographic predictors of symptomatic remission in individuals who do not convert to psychosis. The predictive power of the models in this study suggest that remission represents a unique clinical phenomenon. Further study is warranted to best understand factors contributing to resilience and recovery from the CHR-P state.<\/jats:p>","DOI":"10.1093\/schbul\/sbab115","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:45:22Z","timestamp":1631101522000},"page":"395-404","source":"Crossref","is-referenced-by-count":18,"title":["Individualized Prediction of Prodromal Symptom Remission for Youth at Clinical High Risk for Psychosis"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0398-803X","authenticated-orcid":false,"given":"Michelle A","family":"Worthington","sequence":"first","affiliation":[{"name":"Department of Psychology, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Addington","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hotchkiss Brain Institute, Calgary, AB, 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