{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:56:31Z","timestamp":1792115791347,"version":"4.4.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Swiss National Science Foundation Project Funding","award":["144260"],"award-info":[{"award-number":["144260"]}]},{"name":"Swiss National Science Foundation Project Funding","award":["159968"],"award-info":[{"award-number":["159968"]}]},{"name":"SNSF National Center of Competence in Research","award":["185897"],"award-info":[{"award-number":["185897"]}]},{"DOI":"10.13039\/100009152","name":"Bertarelli Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009152","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one\u2019s actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophrenia. However, it is not clear if agency deficits are a precursor or a result of psychosis. Here, we investigated full body agency using virtual reality in a cohort of 22q11 deletion syndrome participants with a genetic propensity for schizophrenia. In two experiments employing virtual reality, full body motion tracking, and online feedback, we investigated SoA in two separate domains. Our results show that participants with 22q11DS had a considerable deficit in monitoring their actions, compared to age-matched controls in both the temporal and spatial domain. This was coupled with a bias toward erroneous attribution of actions to the self. These results indicate that nonpsychotic 22q11DS participants have a domain general deficit in the conscious sensorimotor mechanisms underlying the bodily self. Our data reveal an abnormality in the SoA in a cohort with a genetic predisposition for schizophrenia, but without psychosis, providing evidence that deficits in delineation of the self may be a precursor rather than a result of the psychotic state.<\/jats:p>","DOI":"10.1093\/schbul\/sbab143","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T15:12:18Z","timestamp":1637593938000},"page":"495-504","source":"Crossref","is-referenced-by-count":29,"title":["Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-617X","authenticated-orcid":false,"given":"Roy","family":"Salomon","sequence":"first","affiliation":[{"name":"Gonda Multidisciplinary Brain Research Center, Bar Ilan University (BIU), Ramat-Gan, Israel"},{"name":"Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-4118","authenticated-orcid":false,"given":"Oliver Alan","family":"Kannape","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Galvan","family":"Debarba","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"},{"name":"Department of Digital Design, IT University of Copenhagen, Copenhagen, Denmark"},{"name":"Immersive Interaction Group, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariia","family":"Kaliuzhna","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"},{"name":"Clinical and Experimental Psychopathology Group, Department of Psychiatry, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maude","family":"Schneider","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland"},{"name":"Clinical Psychology Unit for Intellectual and Developmental Disabilities, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6011-4921","authenticated-orcid":false,"given":"Nathan","family":"Faivre","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"},{"name":"Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Eliez","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Blanke","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"},{"name":"Department of Clinical Neurosciences, Faculty of Medicine, University Hospital, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"issue":"5","key":"2022030111210084200_CIT0001","doi-asserted-by":"crossref","first-page":"e151; quiz e175","DOI":"10.1371\/journal.pmed.0020151","article-title":"The 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