{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:09:43Z","timestamp":1791500983731,"version":"4.3.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008062","name":"Alicia Koplowitz Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015756","name":"Janssen Cilag","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015756","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Deakin University Centre of Research Excellence in Psychiatric Treatment Postgraduate Research Scholarship"},{"DOI":"10.13039\/501100001778","name":"Deakin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001778","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rotary Club of Geelong"},{"name":"NARSAD Young Investigator Award","award":["22388"],"award-info":[{"award-number":["22388"]}]},{"name":"MRC CDA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Despite the accepted link between childhood adversity (CA) and psychotic disorders, evidence on the relationship between CA and poor functional outcome remains less consistent and has never been reviewed quantitatively. The aim of this meta-analysis was to systematically examine the association between CA and functional outcomes in people with psychotic disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>The study protocol was registered on the International Prospective Register of Systematic Reviews (CRD42021254201). A search was conducted across EMBASE, MEDLINE, PsycINFO, and Cochrane Libraries (CENTRAL) using search terms related to psychosis; CA (general, sexual abuse, physical abuse, emotional abuse, physical neglect, and emotional neglect); and functional outcomes (social, occupational, and general functioning [GF]). We conducted random-effects models, sensitivity and heterogeneity analyses, meta-regressions, and we assessed quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Our meta-analysis comprised 35 studies, including 10 568 cases with psychosis. General CA was negatively associated with GF (28 studies; r\u2005=\u2005\u22120.109, 95%CI\u2005=\u2005\u22120.161 to \u22120.05, P\u2005&amp;lt;\u2005.001), with greater effects in prospective data (10 studies; r\u2005=\u2005\u22120.151, 95% CI\u2005=\u2005\u22120.236 to \u22120.063, P\u2005=\u2005.001). General CA was also associated with social functioning (r\u2005=\u2005\u22120.062, 95% CI\u2005=\u2005\u22120.120 to \u22120.004, P\u2005=\u2005.018) but not occupational outcomes. All CA subtypes except sexual abuse were significantly associated with GF, with emotional and physical neglect showing the largest magnitudes of effect (ranging from r\u2005=\u2005\u22120.199 to r\u2005=\u2005\u22120.250).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis provides evidence for a negative association between general CA, specific subtypes, and general and social functional outcomes in people with psychosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbac105","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:17:25Z","timestamp":1661332645000},"page":"285-296","source":"Crossref","is-referenced-by-count":29,"title":["Association Between Childhood Adversity and Functional Outcomes in People With Psychosis: A 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Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Aas","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London , UK"},{"name":"Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King\u2019s College London , London , UK"},{"name":"NORMENT, Centre for Research on Mental Disorders, Oslo University Hospital and University of Oslo , Oslo , 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Pablo","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Services, South London and Maudsley NHS Foundation Trust , London , UK"},{"name":"Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , UK"},{"name":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alameda","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London , UK"},{"name":"Departamento de Psiquiatr\u00eda, Centro Investigaci\u00f3n Biomedica en Red de Salud Mental (CIBERSAM), Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Roc\u00edo, Universidad de Sevilla 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