{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:20:48Z","timestamp":1788790848247,"version":"build-2803163510"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research\u2014iPSYCH","award":["R248-2017-2003"],"award-info":[{"award-number":["R248-2017-2003"]}]},{"DOI":"10.13039\/501100007437","name":"TRYG Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","award":["6152-00002B"],"award-info":[{"award-number":["6152-00002B"]}],"id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mental Health Services of the Capital Region of Denmark"},{"DOI":"10.13039\/100007605","name":"Aarhus University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen","award":["11531"],"award-info":[{"award-number":["11531"]}]},{"DOI":"10.13039\/501100005275","name":"Capital Region of Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Subgroups with distinct levels of neurocognitive functioning exist in children of parents with schizophrenia or bipolar disorder. However, studies investigating the temporal stability of subgroup membership are currently lacking. We hypothesized that a minority of children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) would transition to a different neurocognitive subgroup from age 7 to 11 and that most transitions would be to a more impaired subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Latent profile analysis was used to identify subgroups at two assessments (age 7 and 11) based on the performance of 320 children at FHR-SZ or FHR-BP across eight neurocognitive functions. Temporal stability in subgroup membership was evaluated with latent profile transition analysis. Population-based controls (age 7, n\u2005=\u2005199; age 11, n\u2005=\u2005178) were included as a reference group. Children transitioning to a more impaired subgroup were compared with nontransitioning children on sex, FHR-status, global functioning, and psychopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>At both assessment points, we identified three subgroups based on neurocognitive performance: a moderately\u2013severely impaired, a mildly impaired, and an above-average subgroup. A total of 12.8% of children transitioned to a different subgroup, of which the majority (85.2%) moved to a more impaired subgroup. Parental diagnosis of schizophrenia, but neither parental diagnosis of bipolar disorder, global functioning at age 7, psychopathology, nor sex significantly differentiated children transitioning to a more impaired subgroup from nontransitioning children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During pre-adolescence, neurocognitive developmental lag is associated with being at FHR-SZ. Close attention to these children\u2019s neurocognitive development is indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbac134","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T09:32:12Z","timestamp":1662456732000},"page":"185-195","source":"Crossref","is-referenced-by-count":10,"title":["Neurocognitive Subgroups in Children at Familial High-risk of Schizophrenia or Bipolar disorder: Subgroup Membership Stability or Change From Age 7 to 11\u2014The Danish High Risk and Resilience Study"],"prefix":"10.1093","volume":"49","author":[{"given":"Christina Bruun","family":"Knudsen","sequence":"first","affiliation":[{"name":"Psychosis Research Unit, Aarhus University Hospital \u2013 Psychiatry , Aarhus , Denmark"},{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research \u2013 iPSYCH , Aarhus , Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, Aarhus University , 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