{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:53:04Z","timestamp":1790646784218,"version":"4.1.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"name":"Intramural Research Program of the National Institute of Mental Health","award":["NCT00001247"],"award-info":[{"award-number":["NCT00001247"]}]},{"name":"Intramural Research Program of the National Institute of Mental Health","award":["NCT00001921"],"award-info":[{"award-number":["NCT00001921"]}]},{"name":"Intramural Research Program of the National Institute of Mental Health","award":["NCT00004571"],"award-info":[{"award-number":["NCT00004571"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Hypothesis<\/jats:title>\n                  <jats:p>We used the uniquely high combined spatial and temporal resolution of magnetoencephalography to characterize working memory (WM)-related modulation of beta band activity in neuroleptic-free patients with schizophrenia in comparison to a large sample of performance-matched healthy controls. We also tested for effects of antipsychotic medication on identified differences in these same patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>Inpatients with schizophrenia (n = 21) or psychotic disorder not otherwise specified (n = 4) completed N-back and control tasks during magnetoencephalography while on placebo and during antipsychotic medication treatment, in a blinded, randomized, counterbalanced manner. Healthy, performance-matched controls (N = 100) completed the same tasks. WM-related neural activation was estimated as beta band (14\u201330 Hz) desynchronization throughout the brain in successive 400 ms time windows. Voxel-wise statistical comparisons were performed between controls and patients while off-medication at each time window. Significant clusters resulting from this between-groups analysis were then used as regions-of-interest, the activations of which were compared between on- and off-medication conditions in patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>Controls showed beta-band desynchronization (activation) of a fronto-parietal network immediately preceding correct button press responses\u2013the time associated with WM updating and task execution. Altered activation in medication-free patients occurred largely during this time, in prefrontal, parietal, and visual cortices. Medication altered patients\u2019 neural responses such that the activation time courses in these regions-of-interest more closely resembled those of controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings demonstrate that WM-related beta band alterations in schizophrenia are time-specific and associated with neural systems targeted by antipsychotic medications. Future studies may investigate this association by examining its potential neurochemical basis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbac178","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T11:31:50Z","timestamp":1676115110000},"page":"669-678","source":"Crossref","is-referenced-by-count":6,"title":["Spatiotemporal Alterations in Working Memory-Related Beta Band Neuromagnetic Activity of Patients With Schizophrenia On and Off Antipsychotic Medication: Investigation With MEG"],"prefix":"10.1093","volume":"49","author":[{"given":"Daniel Y","family":"Rubinstein","sequence":"first","affiliation":[{"name":"Section on Integrative Neuroimaging, National Institute of Mental Health, Intramural Research Program, NIH, DHHS , Bethesda, MD , USA"},{"name":"Clinical and Translational Neuroscience Branch, National Institute of Mental Health, Intramural Research Program, NIH, DHHS , Bethesda, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Section on Integrative Neuroimaging, National Institute of Mental Health, Intramural Research Program, NIH, DHHS , Bethesda, MD , USA"},{"name":"Clinical and Translational Neuroscience Branch, National Institute of Mental Health, Intramural Research Program, NIH, DHHS , Bethesda, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W","family":"Carver","sequence":"additional","affiliation":[{"name":"MEG Core Facility, NIH, DHHS , Bethesda, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Holroyd","sequence":"additional","affiliation":[{"name":"MEG Core Facility, NIH, DHHS , Bethesda, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A","family":"Apud","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience 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