{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:29:16Z","timestamp":1784874556666,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo from Chile"},{"name":"ANILLO","award":["PIA ACT1414"],"award-info":[{"award-number":["PIA ACT1414"]}]},{"name":"ANILLO","award":["IA ACT192064"],"award-info":[{"award-number":["IA ACT192064"]}]},{"name":"Nucleus for Cardiovascular Magnetic Resonance"},{"name":"Pablo Le\u00f3n-Ortiz, Francisco Reyes-Madrigal"},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH110270"],"award-info":[{"award-number":["R01 MH110270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Hypothesis<\/jats:title>\n                  <jats:p>Abnormal functional connectivity between brain regions is a consistent finding in schizophrenia, including functional magnetic resonance imaging (fMRI) studies. Recent studies have highlighted that connectivity changes in time in healthy subjects. We here examined the temporal changes in functional connectivity in patients with a first episode of psychosis (FEP). Specifically, we analyzed the temporal order in which whole-brain organization states were visited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>Two case-control studies, including in each sample a subgroup scanned a second time after treatment. Chilean sample included 79 patients with a FEP and 83 healthy controls. Mexican sample included 21 antipsychotic-na\u00efve FEP patients and 15 healthy controls. Characteristics of the temporal trajectories between whole-brain functional connectivity meta-states were examined via resting-state functional MRI using elements of network science. We compared the cohorts of cases and controls and explored their differences as well as potential associations with symptoms, cognition, and antipsychotic medication doses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>We found that the temporal sequence in which patients\u2019 brain dynamics visited the different states was more redundant and segregated. Patients were less flexible than controls in changing their network in time from different configurations, and explored the whole landscape of possible states in a less efficient way. These changes were related to the dose of antipsychotics the patients were receiving. We replicated the relationship with antipsychotic medication in the antipsychotic-na\u00efve FEP sample scanned before and after treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We conclude that psychosis is related to a temporal disorganization of the brain\u2019s dynamic functional connectivity, and this is associated with antipsychotic medication use.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbac187","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T23:40:28Z","timestamp":1670370028000},"page":"706-716","source":"Crossref","is-referenced-by-count":21,"title":["Dysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis"],"prefix":"10.1093","volume":"49","author":[{"given":"Juan P","family":"Ramirez-Mahaluf","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-1305","authenticated-orcid":false,"given":"\u00c1ngeles","family":"Tepper","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Maria","family":"Alliende","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Mena","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"},{"name":"Institute of Cognitive Neuroscience, University College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Paz","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Early Intervention Program, Instituto Psiqui\u00e1trico Dr. J Horwitz Barak , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Iruretagoyena","sequence":"additional","affiliation":[{"name":"Early Intervention Program, Instituto Psiqui\u00e1trico Dr. J Horwitz Barak , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Nachar","sequence":"additional","affiliation":[{"name":"Early Intervention Program, Instituto Psiqui\u00e1trico Dr. J Horwitz Barak , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-4119","authenticated-orcid":false,"given":"Francisco","family":"Reyes-Madrigal","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Psychiatry, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda , Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Le\u00f3n-Ortiz","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Psychiatry, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda , Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Mora-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Fray Bernardino \u00c1lvarez , Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Ossandon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"},{"name":"Center for Integrative Neuroscience, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Gonzalez-Valderrama","sequence":"additional","affiliation":[{"name":"Early Intervention Program, Instituto Psiqui\u00e1trico Dr. J Horwitz Barak , Santiago , Chile"},{"name":"School of Medicine, Universidad Finis Terrae , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-2369","authenticated-orcid":false,"given":"Juan","family":"Undurraga","sequence":"additional","affiliation":[{"name":"Early Intervention Program, Instituto Psiqui\u00e1trico Dr. J Horwitz Barak , Santiago , Chile"},{"name":"Department of Neurology and Psychiatry, Faculty of Medicine, Cl\u00ednica Alemana Universidad del Desarrollo , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-1642","authenticated-orcid":false,"given":"Camilo","family":"de la Fuente-Sandoval","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Psychiatry, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda , Mexico City , Mexico"},{"name":"Neuropsychiatry Department, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda , Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-656X","authenticated-orcid":false,"given":"Nicolas A","family":"Crossley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"},{"name":"Biomedical 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