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However, the pathways through which this occurs have not been previously investigated. We hypothesized that cognitive ability and inflammation would partly explain this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Data were utilized from the Environmental-Risk Longitudinal Twin Study, a cohort of 2232 children born in 1994\u20131995 in England and Wales and followed to age 18. Socioenvironmental adversities were measured from birth to age 10 and classified into physical risk (defined by high urbanicity and air pollution) and socioeconomic risk (defined by high neighborhood deprivation, neighborhood disorder, and family disadvantage). Cognitive abilities (overall, crystallized, fluid, and working memory) were assessed at age 12; and inflammatory markers (C-reactive protein, interleukin-6, soluble urokinase plasminogen activator receptor) were measured at age 18 from blood samples. Participants were interviewed at age 18 regarding psychotic experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Higher physical risk and socioeconomic risk were associated with increased odds of psychotic experiences in adolescence. The largest mediation pathways were from socioeconomic risk via overall cognitive ability and crystallized ability, which accounted for ~11% and ~19% of the association with psychotic experiences, respectively. No statistically significant pathways were found via inflammatory markers in exploratory (partially cross-sectional) analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cognitive ability, especially crystallized ability, may partly explain the association between childhood socioenvironmental adversity and adolescent psychotic experiences. Interventions to support cognitive development among children living in disadvantaged settings could buffer them against developing subclinical psychotic phenomena.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbad017","type":"journal-article","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T04:45:46Z","timestamp":1679201146000},"page":"1042-1054","source":"Crossref","is-referenced-by-count":17,"title":["Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort"],"prefix":"10.1093","volume":"49","author":[{"given":"Joanne B","family":"Newbury","sequence":"first","affiliation":[{"name":"King\u2019s College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience , London , UK"},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol , Bristol , 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L","family":"Odgers","sequence":"additional","affiliation":[{"name":"Social Science Research Institute, Duke University , Durham, NC , USA"},{"name":"Department of Psychological Science, School of Social Ecology, University of California, Irvine , Irvine, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D","family":"Howe","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School, University of Bristol , Bristol , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Bakolis","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Centre for Implementation Science, Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience , London , UK"},{"name":"King\u2019s College London, Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience , London , 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