{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:18:44Z","timestamp":1791569924203,"version":"4.3.4"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971252"],"award-info":[{"award-number":["81971252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1904130"],"award-info":[{"award-number":["U1904130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171498"],"award-info":[{"award-number":["82171498"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001407"],"award-info":[{"award-number":["82001407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81825009"],"award-info":[{"award-number":["81825009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major science and technology projects of Henan Province","award":["201300310200"],"award-info":[{"award-number":["201300310200"]}]},{"name":"Science and technology research project of Henan Province","award":["212102310587"],"award-info":[{"award-number":["212102310587"]}]},{"name":"Science and technology research project of Henan Province","award":["222102310130"],"award-info":[{"award-number":["222102310130"]}]},{"name":"Open program of Henan clinical research center for mental disorders","award":["2021-zxkfkt-006"],"award-info":[{"award-number":["2021-zxkfkt-006"]}]},{"name":"Medical science and technology research project of Henan Province","award":["LHGJ20210541"],"award-info":[{"award-number":["LHGJ20210541"]}]},{"name":"Open Program of the"},{"name":"Henan Biological Psychiatry Key Laboratory","award":["ZDSYS2016002"],"award-info":[{"award-number":["ZDSYS2016002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Evidence from functional and structural research suggests that abnormal brain activity plays an important role in the pathophysiology of schizophrenia (SZ). However, limited studies have focused on post-treatment changes, and current conclusions are inconsistent.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n We recruited 104 SZ patients to have resting-state functional magnetic resonance imaging scans at baseline and 8 weeks of treatment with second-generation antipsychotics, along with baseline scanning of 86 healthy controls (HCs) for comparison purposes. Individual regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and degree centrality values were calculated to evaluate the functional activity. The Positive and Negative Syndrome Scale (PANSS) and MATRICS Consensus Cognitive Battery were applied to measure psychiatric symptoms and cognitive impairment in SZ patients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Compared with HCs at baseline, SZ patients had higher ALFF and ReHo values in the bilateral inferior temporal gyrus, inferior frontal gyrus, and lower ALFF and ReHo values in fusiform gyrus and precuneus. Following 8 weeks of treatment, ReHo was increased in right medial region of the superior frontal gyrus (SFGmed) and decreased in the left middle occipital gyrus and the left postcentral gyrus. Meanwhile, ReHo of the right SFGmed was increased after treatment in the response group (the reduction rate of PANSS \u226550%). Enhanced ALFF in the dorsolateral of SFG correlated with improvement in depressive factor score.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These findings provide novel evidence for the abnormal functional activity hypothesis of SZ, suggesting that abnormality of right SFGmed can be used as a biomarker of treatment response in SZ.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/schbul\/sbad054","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T15:41:09Z","timestamp":1682091669000},"page":"1336-1344","source":"Crossref","is-referenced-by-count":40,"title":["Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A Longitudinal Resting-State fMRI Study"],"prefix":"10.1093","volume":"49","author":[{"given":"Xue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University , Xinxiang , China"},{"name":"Henan Key Lab of 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