{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:50:08Z","timestamp":1756993808068,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>While the evolution of our modern concepts of mania and melancholia over the 19th century is relatively well-understood, no such clear narrative exists for the nonaffective psychotic syndromes that culminated in Kraepelin\u2019s concept of dementia praecox in 1899. These narratives were relatively distinct in Germany and France. An important milestone in the French literature is the 1852 essay by the alienist and polymath Charles Las\u00e8gue which contained the first detailed modern description of a persecutory delusional syndrome. Las\u00e8gue was a careful clinical observer who emphasized a symptomatic approach to psychiatric nosology and was less concerned with course and outcome. He details the evolution of persecutory delusions from increasing referential observations of real events, to the resulting anxious confusion and then the emergence of explanatory delusional beliefs. Once formed, these beliefs, he notes, are relatively impervious to correction. Las\u00e8gue was unusual for his time in emphasizing a \u201cfirst-person perspective\u201d on psychotic experiences, and quotes from his patients in his case history, of which he presents 15. Of these, 12 had auditory hallucinations and 4 passivity phenomena. While conceptualized differently than mid-19th century pre-Kraepelinian German writing on delusional syndromes, and unique on its focus on persecutory delusions, Las\u00e8gue\u2019s important essay shared a common view on the key features of a broad nonaffective delusional-hallucinatory syndrome. It was this syndrome that Kraepelin, over multiple drafts in the first 6 editions of his textbook from 1883 to 1899, was to divide into his mature concepts of paranoia and the paranoid subtype of dementia praecox.<\/jats:p>","DOI":"10.1093\/schbul\/sbad086","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T12:15:45Z","timestamp":1686831345000},"page":"1185-1193","source":"Crossref","is-referenced-by-count":2,"title":["Tracing the Roots of Dementia Praecox: Charles Las\u00e8gue and his 1852 Essay \u201cDu D\u00e9lire De Pers\u00e9cutions\u201d (On Persecutory Delusions)"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-6570","authenticated-orcid":false,"given":"Kenneth S","family":"Kendler","sequence":"first","affiliation":[{"name":"Psychiatry Department, Virginia Commonwealth University , Richmond, VA 980126 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"volume-title":"Nosology: Or, a Systematic Arrangement of Diseases, by Classes, Orders, Genera, and Species","year":"1800","author":"Cullen","key":"2023090709182070400_CIT0001"},{"volume-title":"A Treatise on Insanity, in which are contained The Principles of a New and More Practical Nosology of Maniacal Disorders","year":"1806","author":"Pinel","key":"2023090709182070400_CIT0002"},{"issue":"16","key":"2023090709182070400_CIT0003","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1017\/S0033291720004183","article-title":"Phillipe Pinel and the foundations of modern psychiatric nosology","volume":"50","author":"Kendler","year":"2020","journal-title":"Psychol Med."},{"key":"2023090709182070400_CIT0004","volume-title":"Psychiatrie: Ein Lehrbuch fur Studirende und Aerzte","author":"Kraepelin","year":"1899","edition":"6"},{"volume-title":"Psychiatry: A Textbook for Students and Physicians (Translation of the 6th Edition of Psychiatrie-Translator Volume 1-Helga Metoui)","year":"1990","author":"Kraepelin","key":"2023090709182070400_CIT0005"},{"volume-title":"Psychiatry, A Textbook for Students and Physicians (Translation of the 6th Edition of Psychiatrie-Translator Volume 2-Sabine Ayed)","year":"1990","author":"Kraepelin","key":"2023090709182070400_CIT0006"},{"volume-title":"From Melancholia to Depression: Disordered Mood in Nineteenth-Century Psychiatry","year":"2020","author":"Jansson","key":"2023090709182070400_CIT0007"},{"issue":"9","key":"2023090709182070400_CIT0008","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1038\/s41380-020-0657-0","article-title":"The origin of our modern concept of mania in texts from 1780-1900","volume":"25","author":"Kendler","year":"2020","journal-title":"Mol Psychiatry."},{"issue":"8","key":"2023090709182070400_CIT0009","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jamapsychiatry.2019.4709","article-title":"The origin of our modern concept of depression-the history of melancholia from 1780-1880: a review","volume":"77","author":"Kendler","year":"2020","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"2023090709182070400_CIT0010","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/schbul\/sbz101","article-title":"The development of kraepelin\u2019s mature diagnostic concept of catatonic dementia praecox: a close reading of relevant texts","volume":"46","author":"Kendler","year":"2020","journal-title":"Schizophr Bull."},{"issue":"1","key":"2023090709182070400_CIT0011","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41380-019-0411-7","article-title":"The development of Kraepelin\u2019s mature diagnostic concept of hebephrenia: a close reading of relevant texts of Hecker, Daraszkiewicz, and Kraepelin","volume":"25","author":"Kendler","year":"2020","journal-title":"Mol Psychiatry."},{"volume-title":"Die Katatonie Oder Das Spannungsirresein: Eine klinische Form psychischer Krankheit","year":"1874","author":"Kahlbaum","key":"2023090709182070400_CIT0012"},{"volume-title":"Catatonia: Translated from the German Die Katatonie oder das Spannungsirresein (1874) by Y. 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