{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:59:47Z","timestamp":1782125987731,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Spanish Ministry of Health","award":["PI18\/00976"],"award-info":[{"award-number":["PI18\/00976"]}]},{"name":"Spanish Ministry of Health","award":["21\/00330"],"award-info":[{"award-number":["21\/00330"]}]},{"name":"Spanish Ministry of Health","award":["PI18\/0242\/PI21\/0391"],"award-info":[{"award-number":["PI18\/0242\/PI21\/0391"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PI18\/0242\/PI21\/0391"],"award-info":[{"award-number":["PI18\/0242\/PI21\/0391"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022335","name":"IDIBAPS","doi-asserted-by":"publisher","award":["IBPS15-EE-3688"],"award-info":[{"award-number":["IBPS15-EE-3688"]}],"id":[{"id":"10.13039\/501100022335","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3 Cl\u00ednic Recerca Biom\u00e8dica and Brain and Behavior Research Foundation","award":["26731"],"award-info":[{"award-number":["26731"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Dynamic functional connectivity (dFC) alterations have been reported in patients with adult-onset and chronic psychosis. We sought to examine whether such abnormalities were also observed in patients with first episode, adolescent-onset psychosis (AOP), in order to rule out potential effects of chronicity and protracted antipsychotic treatment exposure. AOP has been suggested to have less diagnostic specificity compared to psychosis with onset in adulthood and occurs during a period of neurodevelopmental changes in brain functional connections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>Seventy-nine patients with first episode, AOP (36 patients with schizophrenia-spectrum disorder, SSD; and 43 with affective psychotic disorder, AF) and 54 healthy controls (HC), aged 10 to 17 years were included. Participants underwent clinical and cognitive assessments and resting-state functional magnetic resonance imaging. Graph-based measures were used to analyze temporal trajectories of dFC, which were compared between patients with SSD, AF, and HC. Within patients, we also tested associations between dFC parameters and clinical variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>Patients with SSD temporally visited the different connectivity states in a less efficient way (reduced global efficiency), visiting fewer nodes (larger temporal modularity, and increased immobility), with a reduction in the metabolic expenditure (cost and leap size), relative to AF and HC (effect sizes: Cohen\u2019s D, ranging 0.54 to.91). In youth with AF, these parameters did not differ compared to HC. Connectivity measures were not associated with clinical severity, intelligence, cannabis use, or dose of antipsychotic medication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>dFC measures hold potential towards the development of brain-based biomarkers characterizing adolescent-onset SSD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbad107","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:32:14Z","timestamp":1692736334000},"page":"418-426","source":"Crossref","is-referenced-by-count":3,"title":["Altered Temporal Dynamics of Resting-State Functional Magnetic Resonance Imaging in Adolescent-Onset First-Episode Psychosis"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0810-4336","authenticated-orcid":false,"given":"Mireia","family":"Masias 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Ortu\u00f1o","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Neuroscience, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Agust\u00ed Pi i Sunyer (IDIBAPS) , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ilzarbe","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Neuroscience, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Agust\u00ed Pi i Sunyer (IDIBAPS) , Barcelona , Spain"},{"name":"Department of Child and Adolescent Psychiatry, 2017SGR881, Institute of Neuroscience, Hospital Cl\u00ednic de Barcelona , Barcelona , Spain"},{"name":"Group G04, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III , Spain"},{"name":"Department of Medicine, 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