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However, evidence supports the resilience-enhancing effect of positive factors on psychosis outcome. The Differential Susceptibility (DS) model proposes that common genetic variants may confer not only disproportionate responsiveness to negative environments, but also greater sensitivity to positive, resilience-enhancing conditions. This study is the first to apply the DS model to the expression of subclinical psychosis, employing polygenic risk scores of environmental sensitivity (PRS-ES). PRS-ES were hypothesized to moderate, in a DS manner, associations between childhood adversity and psychosis, affective, and anxiety dimensions in young adults. An exploratory goal examined whether PRS for psychotic-like experiences (PRS-PLE) also showed DS patterns.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>PRS, schizotypy, PLE, depression, anxiety, and childhood adversity ratings were obtained for 197 nonclinical young adults. LEGIT software for testing competitive-confirmatory GxE models was employed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>Results largely supported DS: Individuals high on PRS-ES showed increased subclinical psychosis, depression, and anxiety if they had experienced elevated childhood adversity, and lower symptoms if exposed to low levels of adversity as compared with those with low PRS-ES. Similarly, PRS-PLE moderated the effect of adversity on PLE, positive schizotypy, and depression following the DS model, but only PRS-ES moderation on PLE survived statistical correction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results suggest that genetic DS to the environment is relevant to psychosis, depression, and anxiety. Current debates on reconceptualization of genetic \u201crisk\u201d and resilience may benefit from this insight that support optimistic views on preventative efforts for early detection and intervention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbad130","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:55:22Z","timestamp":1692737722000},"page":"S95-S106","source":"Crossref","is-referenced-by-count":10,"title":["Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-1238","authenticated-orcid":false,"given":"Neus","family":"Barrantes-Vidal","sequence":"first","affiliation":[{"name":"Departament de Psicologia Cl\u00ednica i de la Salut, Universitat Aut\u00f2noma de Barcelona , Barcelona ,","place":["Spain"]},{"name":"Sant Pere Claver\u2014Fundaci\u00f3 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,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Papiol","sequence":"additional","affiliation":[{"name":"CIBER de Salud Mental, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich , Munich ,","place":["Germany"]},{"name":"Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-0711","authenticated-orcid":false,"given":"Marian J","family":"Bakermans-Kranenburg","sequence":"additional","affiliation":[{"name":"ISPA, University Institute of Psychological, Social and Life Sciences , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1144-454X","authenticated-orcid":false,"given":"Marinus H","family":"van IJzendoorn","sequence":"additional","affiliation":[{"name":"Department of Psychology, Education and Child Studies, Erasmus University Rotterdam , Rotterdam ,","place":["the Netherlands"]},{"name":"Research Department of Clinical, Education and Health Psychology, Faculty of Brain Sciences, UCL , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-4008","authenticated-orcid":false,"given":"Alexia","family":"Jolicoeur-Martineau","sequence":"additional","affiliation":[{"name":"Samsung Advanced Institute of Technology AI Lab , Montreal ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1116-5954","authenticated-orcid":false,"given":"Thomas R","family":"Kwapil","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Illinois at Urbana-Champaign , Champaign, IL 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