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Here, we hypothesized that brain regions identified by structural and functional imaging studies of schizophrenia could be reconciled in a common network.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>We systematically reviewed the case-control studies that estimated the brain morphology or resting-state local function for schizophrenia patients in the literature. Using the healthy human connectome (n\u2005=\u2005652) and a validated technique \u201ccoordinate network mapping\u201d to identify a common brain network affected in schizophrenia. Then, the specificity of this schizophrenia network was examined by independent data collected from 13 meta-analyses. The clinical relevance of this schizophrenia network was tested on independent data of medication, neuromodulation, and brain lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>We identified 83 morphological and 60 functional studies comprising 7389 patients with schizophrenia and 7408 control subjects. The \u201ccoordinate network mapping\u201d showed that the atrophy and dysfunction coordinates were functionally connected to a common network although they were spatially distant from each other. Taking all 143 studies together, we identified the schizophrenia network with hub regions in the bilateral anterior cingulate cortex, insula, temporal lobe, and subcortical structures. Based on independent data from 13 meta-analyses, we showed that these hub regions were specifically connected with regions of cortical thickness changes in schizophrenia. More importantly, this schizophrenia network was remarkably aligned with regions involving psychotic symptom remission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Neuroimaging abnormalities in cross-sectional schizophrenia studies converged into a common brain network that provided testable targets for developing precise therapies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbae003","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T02:09:30Z","timestamp":1705975770000},"page":"545-556","source":"Crossref","is-referenced-by-count":25,"title":["Heterogeneous Brain Abnormalities in Schizophrenia Converge on a Common Network Associated With Symptom Remission"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-9571","authenticated-orcid":false,"given":"Yingru","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University , Hefei , 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Hospital of Anhui Medical University, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongliang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Fourth People\u2019s Hospital of Hefei, Anhui Mental Health Center , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghua","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University , Hefei , China"},{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University , Hefei , China"},{"name":"Institute of Artificial Intelligence, Hefei Comprehensive National Science Center , Hefei , China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders , Hefei , China"},{"name":"Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health , Hefei , China"},{"name":"Anhui Institute of Translational Medicine , Hefei , 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