{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:16:24Z","timestamp":1788207384058,"version":"build-2803163510"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","award":["4100043366"],"award-info":[{"award-number":["4100043366"]}],"id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical & Translational Research Center, Perelman School of Medicine, University of Pennsylvania","award":["UL1-RR-024134"],"award-info":[{"award-number":["UL1-RR-024134"]}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD087485"],"award-info":[{"award-number":["R01HD087485"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Hypothesis<\/jats:title>\n                  <jats:p>Based on a childhood intervention from ages 3 to 5 years that included additional fish consumption and which resulted in reduced schizotypal personality at age 23, we had previously hypothesized that omega-3 could reduce schizotypy. The current study tests the hypothesis that omega-3 supplementation reduces schizotypy in children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>In this intention-to-treat, randomized, single-blind, stratified, factorial trial, a community sample of 290 children aged 11\u201312 years were randomized into Omega-3 Only, Cognitive Behavioral Therapy (CBT) Only, Omega-3\u2005+\u2005CBT, and Control groups. Schizotypy was assessed using the SPQ-C (Schizotypal Personality Questionnaire for Children) at 0 months (baseline), 3 months (end of treatment), 6 months (3 months post-treatment), and 12 months (9 months post-treatment).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>A significant group\u2005\u00d7\u2005time interaction (P\u2005=\u2005.013) indicated that, compared with Controls, total schizotypy scores were reduced in both Omega-3 Only and Omega-3\u2005+\u2005CBT groups immediately post-treatment (d\u2005=\u20050.56 and 0.47, respectively), and also 3 months after supplementation terminated (d\u2005=\u20050.49, d\u2005=\u20050.70). Stronger findings were observed for the interpersonal schizotypy factor, with both omega-3 groups showing reductions 9 months post-treatment compared with the CBT Only group. Schizotypy reductions were significantly stronger for those with higher dietary intake of omega-3 at intake. Sensitivity analyses confirmed findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Results are unique in the field and suggest that omega-3 can help reduce schizotypal personality in community-residing children. From an epidemiological standpoint, if replicated and extended, these findings could have implications for early prevention of more significant schizotypal features developing later in adolescence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>\u201cHealthy Brains &amp; Behavior: Understanding and Treating Youth Aggression (HBB).\u201d ClinicalTrials.gov Identifier: NCT00842439, https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00842439.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbae009","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:30:54Z","timestamp":1706808654000},"page":"1117-1126","source":"Crossref","is-referenced-by-count":5,"title":["Omega-3 Supplementation Reduces Schizotypal Personality in Children: A Randomized Controlled 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