{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:50:34Z","timestamp":1769554234500,"version":"3.49.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81920108018"],"award-info":[{"award-number":["81920108018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001440"],"award-info":[{"award-number":["82001440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key R & D Program of Zhejiang","award":["2022C03096"],"award-info":[{"award-number":["2022C03096"]}]},{"name":"Project for Hangzhou Medical Disciplines of Excellence and Key Project for Hangzhou Medical Disciplines","award":["202004A11"],"award-info":[{"award-number":["202004A11"]}]},{"name":"McLean Foundation Award","award":["401343"],"award-info":[{"award-number":["401343"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cortical thickness (CT) alterations, mismatch negativity (MMN) reductions, and cognitive deficits are robust findings in first-episode psychosis (FEP). However, most studies focused on medicated patients, leaving gaps in our understanding of the interrelationships between CT, MMN, neurocognition, and psychosocial functioning in unmedicated FEP. This study aimed to employ multiple mediation analysis to investigate potential pathways among these variables in unmedicated drug-na\u00efve FEP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled 28 drug-na\u00efve FEP and 34 age and sex-matched healthy controls. Clinical symptoms, neurocognition, psychosocial functioning, auditory duration MMN, and T1 structural magnetic resonance imaging data were collected. We measured CT in the superior temporal gyrus (STG), a primary MMN-generating region.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found a significant negative correlation between MMN amplitude and bilateral CT of STG (CT_STG) in FEP (left: r\u2005=\u2005\u2212.709, P\u2005&amp;lt;\u2005.001; right: r\u2005=\u2005\u2212.612, P\u2005=\u2005.008). Multiple mediation models revealed that a thinner left STG cortex affected functioning through both direct (24.66%) and indirect effects (75.34%). In contrast, the effects of the right CT_STG on functioning were mainly mediated through MMN and neurocognitive pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Bilateral CT_STG showed significant association with MMN, and MMN plays a mediating role between CT and cognition. Both MMN alone and its interaction with cognition mediated the effects of structural alterations on psychosocial function. The decline in overall function in FEP may stem from decreased CT_STG, leading to subsequent MMN deficits and neurocognitive dysfunction. These findings underline the crucial role of MMN in elucidating how subtle structural alterations can impact neurocognition and psychosocial function in FEP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbae026","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T15:50:36Z","timestamp":1713455436000},"page":"827-838","source":"Crossref","is-referenced-by-count":2,"title":["Identify Potential Causal Relationships Between Cortical Thickness, Mismatch Negativity, Neurocognition, and Psychosocial Functioning in Drug-Na\u00efve First-Episode Psychosis Patients"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4129-7149","authenticated-orcid":false,"given":"Xiaojing","family":"Li","sequence":"first","affiliation":[{"name":"Affiliated Mental Health Center and Hangzhou Seventh People\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou 310058 , China"},{"name":"Nanhu Brain-Computer Interface Institute , Hangzhou 311100 , China"},{"name":"Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University , 1369 West Wenyi Road, Hangzhou 311121 , China"},{"name":"NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University , Hangzhou 310058 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4109-3878","authenticated-orcid":false,"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center and Hangzhou Seventh People\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou 310058 , China"},{"name":"Nanhu Brain-Computer Interface Institute , Hangzhou 311100 , China"},{"name":"Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University , 1369 West Wenyi Road, Hangzhou 311121 , China"},{"name":"NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University , Hangzhou 310058 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-1349","authenticated-orcid":false,"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University , Chengdu 610041, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Deng","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center and Hangzhou Seventh People\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou 310058 , China"},{"name":"Nanhu Brain-Computer Interface Institute , Hangzhou 311100 , China"},{"name":"Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University , 1369 West Wenyi Road, Hangzhou 311121 , China"},{"name":"NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University , Hangzhou 310058 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingli","family":"Li","sequence":"additional","affiliation":[{"name":"Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University , Chengdu 610041, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Ma","sequence":"additional","affiliation":[{"name":"Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University , Chengdu 610041, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinkun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center and Hangzhou Seventh People\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou 310058 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liansheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University , Chengdu 610041, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjun","family":"Guo","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center and Hangzhou Seventh People\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou 310058 , China"},{"name":"Nanhu Brain-Computer Interface Institute , Hangzhou 311100 , China"},{"name":"Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University , 1369 West Wenyi Road, Hangzhou 311121 , China"},{"name":"NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University , Hangzhou 310058 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Hua","family":"Hall","sequence":"additional","affiliation":[{"name":"Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School , Belmont, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-901X","authenticated-orcid":false,"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center and Hangzhou Seventh People\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou 310058 , China"},{"name":"Nanhu Brain-Computer Interface Institute , Hangzhou 311100 , China"},{"name":"Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University , 1369 West Wenyi Road, Hangzhou 311121 , China"},{"name":"NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University , Hangzhou 310058 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