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A critical region particularly vulnerable to environmental insults during adolescence is the ventral hippocampus (vHip). However, the impact of severe stress on vHip redox states and their functional consequences, including behavioral and electrophysiological changes related to SCZ, are not entirely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>After exposing adolescent animals to physical stress (postnatal day, PND31\u201340), we explored social and cognitive behaviors (PND47\u201349), the basal activity of pyramidal glutamate neurons, the number of parvalbumin (PV) interneurons, and the transcriptomic signature of the vHip (PND51). We also evaluated the impact of stress on the redox system, including mitochondrial respiratory function, reactive oxygen species (ROS) production, and glutathione (GSH) levels in the vHip and serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Adolescent-stressed animals exhibited loss of sociability, cognitive impairment, and vHip excitatory\/inhibitory (E\/I) imbalance. Genome-wide transcriptional profiling unveiled the impact of stress on redox system- and synaptic-related genes. Stress impacted mitochondrial respiratory function and changes in ROS levels in the vHip. GSH and glutathione disulfide (GSSG) levels were elevated in the serum of stressed animals, while GSSG was also increased in the vHip and negatively correlated with sociability. Additionally, PV interneuron deficits in the vHip caused by adolescent stress were associated with oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results highlight the negative impact of adolescent stress on vHip redox regulation and mitochondrial function, which are partially associated with E\/I imbalance and behavioral abnormalities related to SCZ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbae033","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T12:34:29Z","timestamp":1709814869000},"page":"501-512","source":"Crossref","is-referenced-by-count":16,"title":["Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory\/Inhibitory Imbalance Related to Schizophrenia"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-5695","authenticated-orcid":false,"given":"Thamyris","family":"Santos-Silva","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio F\u00e1bio Baeta","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Ribeir\u00e3o Preto Pharmaceutical Sciences School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do\u011fukan","family":"Hazar \u00dclgen","sequence":"additional","affiliation":[{"name":"Brain Mind Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne , Lausanne 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