{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:54:37Z","timestamp":1791618877698,"version":"4.3.4"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["10001CL_169783"],"award-info":[{"award-number":["10001CL_169783"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SCHL 1969-3\/1"],"award-info":[{"award-number":["SCHL 1969-3\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heisenberg Program","award":["SCHL 1969-4\/1-5\/1"],"award-info":[{"award-number":["SCHL 1969-4\/1-5\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Negative symptoms in schizophrenia (SZ), such as apathy and diminished expression, have limited treatments and significantly impact daily life. Our study focuses on the functional division of the striatum: limbic\u2014motivation and reward, associative\u2014cognition, and sensorimotor\u2014sensory and motor processing, aiming to identify potential biomarkers for negative symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>This longitudinal, 2-center resting-state-fMRI (rsfMRI) study examines striatal seeds-to-whole-brain functional connectivity. We examined connectivity aberrations in patients with schizophrenia (PwSZ), focusing on stable group differences across 2-time points using intra-class-correlation and associated these with negative symptoms and measures of cognition. Additionally, in PwSZ, we used negative symptoms to predict striatal connectivity aberrations at the baseline and used the striatal aberration to predict symptoms 9 months later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>A total of 143 participants (77 PwSZ, 66 controls) from 2 centers (Berlin\/Geneva) participated. We found sensorimotor-striatum and associative-striatum hypoconnectivity. We identified 4 stable hypoconnectivity findings over 3 months, revealing striatal-fronto-parietal-cerebellar hypoconnectivity in PwSZ. From those findings, we found hypoconnectivity in the bilateral associative striatum with the bilateral paracingulate-gyrus and the anterior cingulate cortex in PwSZ. Additionally, hypoconnectivity between the associative striatum and the superior frontal gyrus was associated with lower cognition scores in PwSZ, and weaker sensorimotor striatum connectivity with the superior parietal lobule correlated negatively with diminished expression and could predict symptom severity 9 months later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Importantly, patterns of weaker sensorimotor striatum and superior parietal lobule connectivity fulfilled the biomarker criteria: clinical significance, reflecting underlying pathophysiology, and stability across time and centers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbae052","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T19:33:09Z","timestamp":1714505589000},"page":"1337-1348","source":"Crossref","is-referenced-by-count":8,"title":["Striatal Functional Hypoconnectivity in Patients With Schizophrenia Suffering From Negative Symptoms, Longitudinal Findings"],"prefix":"10.1093","volume":"50","author":[{"given":"Tal","family":"Geffen","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, NeuroCure Clinical Research Center (NCRC) , Campus Mitte, Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samyogita","family":"Hardikar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Smallwood","sequence":"additional","affiliation":[{"name":"Department of Psychology, Queen\u2019s University , Kingston, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariia","family":"Kaliuzhna","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Psychopathology Laboratory, University of Geneva, Faculty of Medicine , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Carruzzo","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Psychopathology Laboratory, University of Geneva, Faculty of Medicine , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerem","family":"B\u00f6ge","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroscience, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Campus Benjamin Franklin, Berlin ,","place":["Germany"]},{"name":"German Center for Mental Health (DZPG) , Partner Site, Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-9050","authenticated-orcid":false,"given":"Marco Matth\u00e4us","family":"Zierhut","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroscience, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Campus Benjamin Franklin, Berlin ,","place":["Germany"]},{"name":"German Center for Mental Health (DZPG) , Partner Site, Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\u00e9 Clinician Scientist Program , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gutwinski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, NeuroCure Clinical Research Center (NCRC) , Campus Mitte, Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7537-4192","authenticated-orcid":false,"given":"Teresa","family":"Katthagen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, NeuroCure Clinical Research Center (NCRC) , Campus Mitte, Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Adult Psychiatry Division, Department of Psychiatry, Geneva University Hospital , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schlagenhauf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, NeuroCure Clinical Research Center (NCRC) , Campus Mitte, 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