{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:55:38Z","timestamp":1792695338304,"version":"4.5.0"},"reference-count":120,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>The glymphatic system (GS), a brain waste clearance pathway, is disrupted in various neurodegenerative and vascular diseases. As schizophrenia shares clinical characteristics with these conditions, we hypothesized GS disruptions in patients with schizophrenia spectrum disorder (SCZ-SD), reflected in increased brain macromolecule (MM) and decreased diffusion-tensor-image-analysis along the perivascular space (DTI-ALPS) index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Forty-seven healthy controls (HCs) and 103 patients with SCZ-SD were studied. Data included 135 proton magnetic resonance spectroscopy (1H-MRS) sets, 96 DTI sets, with 79 participants contributing both. MM levels were quantified in the dorsal-anterior cingulate cortex (dACC), dorsolateral prefrontal cortex, and dorsal caudate (point resolved spectroscopy, echo-time\u2005=\u200535ms). Diffusivities in the projection and association fibers near the lateral ventricle were measured to calculate DTI-ALPS indices. General linear models were performed, adjusting for age, sex, and smoking. Correlation analyses examined relationships with age, illness duration, and symptoms severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>MM levels were not different between patients and HCs. However, left, right, and bilateral DTI-ALPS indices were lower in patients compared with HCs (P\u2005&amp;lt;\u2005.001). In HCs, age was positively correlated with dACC MM and negatively correlated with left, right, and bilateral DTI-ALPS indices (P\u2005&amp;lt;\u2005.001). In patients, illness duration was positively correlated with dACC MM and negatively correlated with the right DTI-ALPS index (P\u2005&amp;lt;\u2005.05). In the entire population, dACC MM and DTI-ALPS indices showed an inverse correlation (P\u2005&amp;lt;\u2005.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest potential disruptions in the GS of patients with SCZ-SD. Improving brain\u2019s waste clearance may offer a potential therapeutic approach for patients with SCZ-SD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbae060","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T20:16:40Z","timestamp":1713385000000},"page":"1396-1410","source":"Crossref","is-referenced-by-count":37,"title":["Evaluation of the Glymphatic System in Schizophrenia Spectrum Disorder Using Proton Magnetic Resonance Spectroscopy Measurement of Brain Macromolecule and Diffusion Tensor Image Analysis Along the Perivascular Space Index"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0984-4141","authenticated-orcid":false,"given":"Ali","family":"Abdolizadeh","sequence":"first","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Torres-Carmona","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaman","family":"Kambari","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Amaev","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmeng","family":"Song","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-5672","authenticated-orcid":false,"given":"Fumihiko","family":"Ueno","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Department of Neuropsychiatry, Keio University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Department of Neuropsychiatry, Keio University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Mahavir","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"De Luca","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Gerretsen","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Campbell Family Mental Health Research Institute, CAMH , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Graff-Guerrero","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto , ON ,","place":["Canada"]},{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Campbell Family Mental Health Research Institute, CAMH , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"2024110900302957300_CIT0001","article-title":"Regulation of Cerebral Metabolic Rate","volume-title":"Basic Neurochemistry: Molecular, Cellular and Medical Aspects","author":"Clarke","year":"1999","edition":"6"},{"issue":"3","key":"2024110900302957300_CIT0002","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI67677","article-title":"Brain-wide pathway for waste clearance captured by contrast-enhanced MRI","volume":"123","author":"Iliff","year":"2013","journal-title":"J Clin Invest."},{"issue":"46","key":"2024110900302957300_CIT0003","doi-asserted-by":"crossref","first-page":"18190","DOI":"10.1523\/JNEUROSCI.1592-13.2013","article-title":"Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain","volume":"33","author":"Iliff","year":"2013","journal-title":"J Neurosci."},{"issue":"4","key":"2024110900302957300_CIT0004","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3171\/2009.5.JNS08945","article-title":"The influence of the relative timing of arterial and subarachnoid space pulse waves on spinal perivascular cerebrospinal fluid flow as a possible factor in syrinx development","volume":"112","author":"Bilston","year":"2010","journal-title":"J Neurosurg."},{"issue":"1","key":"2024110900302957300_CIT0005","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2045-8118-10-36","article-title":"Influence of respiration on cerebrospinal fluid movement using magnetic resonance spin labeling","volume":"10","author":"Yamada","year":"2013","journal-title":"Fluids Barriers CNS"},{"issue":"4","key":"2024110900302957300_CIT0006","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/(SICI)1522-2586(200004)11:4<438::AID-JMRI12>3.0.CO;2-O","article-title":"Detection of a relation between respiration and CSF pulsation with an echoplanar technique","volume":"11","author":"Klose","year":"2000","journal-title":"J Magn Reson Imaging."},{"issue":"12","key":"2024110900302957300_CIT0007","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The glymphatic system: a beginner\u2019s guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem Res."},{"issue":"6","key":"2024110900302957300_CIT0008","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/diagnostics10060344","article-title":"Magnetic resonance imaging and modeling of the glymphatic system","volume":"10","author":"Kaur","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"2024110900302957300_CIT0009","doi-asserted-by":"crossref","first-page":"639140","DOI":"10.3389\/fnins.2021.639140","article-title":"Glymphatic system as a gateway to connect neurodegeneration from periphery to CNS","volume":"15","author":"Natale","year":"2021","journal-title":"Front Neurosci."},{"issue":"3","key":"2024110900302957300_CIT0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2176\/nmc.oa.2020-0274","article-title":"Accumulation of macromolecules in idiopathic normal pressure hydrocephalus","volume":"61","author":"Akiyama","year":"2021","journal-title":"Neurol Med Chir (Tokyo)."},{"issue":"147","key":"2024110900302957300_CIT0011","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med."},{"issue":"1","key":"2024110900302957300_CIT0012","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/jamaneurol.2016.4370","article-title":"Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains","volume":"74","author":"Zeppenfeld","year":"2017","journal-title":"JAMA Neurol"},{"key":"2024110900302957300_CIT0013","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13024-015-0056-1","article-title":"Deletion of aquaporin-4 in APP\/PS1 mice exacerbates brain A\u03b2 accumulation and memory deficits","volume":"10","author":"Xu","year":"2015","journal-title":"Mol Neurodegener."},{"issue":"3","key":"2024110900302957300_CIT0014","doi-asserted-by":"crossref","first-page":"50","DOI":"10.17116\/jnevro201911903150","article-title":"[Pathological changes in human brain biopsies from patients with idiopathic normal pressure hydrocephalus]","volume":"119","author":"Gavrilov","year":"2019","journal-title":"Zh Nevrol Psikhiatr Im S S Korsakova."},{"issue":"5","key":"2024110900302957300_CIT0015","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/01.ATV.0000160548.78317.29","article-title":"Mechanisms, pathophysiology, and therapy of arterial stiffness","volume":"25","author":"Zieman","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"4","key":"2024110900302957300_CIT0016","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.exger.2008.12.004","article-title":"Age-related changes in choroid plexus and blood\u2013cerebrospinal fluid barrier function in the sheep","volume":"44","author":"Chen","year":"2009","journal-title":"Exp Gerontol."},{"issue":"4","key":"2024110900302957300_CIT0017","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn J Radiol"},{"issue":"11","key":"2024110900302957300_CIT0018","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S1474-4422(18)30318-1","article-title":"The glymphatic pathway in neurological disorders","volume":"17","author":"Rasmussen","year":"2018","journal-title":"Lancet Neurol"},{"key":"2024110900302957300_CIT0019","doi-asserted-by":"crossref","first-page":"773951","DOI":"10.3389\/fnagi.2021.773951","article-title":"Diffusion tensor imaging along the perivascular space index in different stages of Parkinson\u2019s disease","volume":"13","author":"Ma","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"2024110900302957300_CIT0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.nbd.2016.05.015","article-title":"Suppression of glymphatic fluid transport in a mouse model of Alzheimer\u2019s disease","volume":"93","author":"Peng","year":"2016","journal-title":"Neurobiol Dis."},{"key":"2024110900302957300_CIT0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/5675014","article-title":"Diagnostic performance of glymphatic system evaluation using diffusion tensor imaging in idiopathic normal pressure hydrocephalus and mimickers","volume":"2019","author":"Yokota","year":"2019","journal-title":"Curr Gerontol Geriatrics Res"},{"key":"2024110900302957300_CIT0022","doi-asserted-by":"crossref","first-page":"118257","DOI":"10.1016\/j.neuroimage.2021.118257","article-title":"Glymphatic clearance function in patients with cerebral small vessel disease","volume":"238","author":"Zhang","year":"2021","journal-title":"Neuroimage."},{"key":"2024110900302957300_CIT0023","doi-asserted-by":"crossref","first-page":"113685","DOI":"10.1016\/j.expneurol.2021.113685","article-title":"The role of glymphatic system in the cerebral edema formation after ischemic stroke","volume":"340","author":"Ji","year":"2021","journal-title":"Exp Neurol."},{"issue":"6","key":"2024110900302957300_CIT0024","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.24271","article-title":"Impairment of paravascular clearance pathways in the aging brain","volume":"76","author":"Kress","year":"2014","journal-title":"Ann Neurol."},{"issue":"6156","key":"2024110900302957300_CIT0025","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science."},{"issue":"3","key":"2024110900302957300_CIT0026","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/scientificamerican0316-44","article-title":"Brain drain","volume":"314","author":"Nedergaard","year":"2016","journal-title":"Sci Am."},{"issue":"10323","key":"2024110900302957300_CIT0027","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0140-6736(21)01730-X","article-title":"Schizophrenia","volume":"399","author":"Jauhar","year":"2022","journal-title":"The Lancet"},{"issue":"1","key":"2024110900302957300_CIT0028","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/epirev\/mxn001","article-title":"A concise overview of incidence, prevalence, and mortality","volume":"30","author":"McGrath","year":"2008","journal-title":"Epidemiol Rev."},{"issue":"6","key":"2024110900302957300_CIT0029","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/schbul\/sbm140","article-title":"Is schizophrenia a syndrome of accelerated aging","volume":"34","author":"Kirkpatrick","year":"2008","journal-title":"Schizophr Bull."},{"key":"2024110900302957300_CIT0030","doi-asserted-by":"crossref","first-page":"256","DOI":"10.14336\/AD.2014.0500256","article-title":"Accelerated aging in schizophrenia patients: the potential role of oxidative stress","volume":"256","author":"Okusaga","year":"2014","journal-title":"Aging Dis"},{"issue":"1","key":"2024110900302957300_CIT0031","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3390\/ijerph20010737","article-title":"Subjective overview of accelerated aging in schizophrenia","volume":"20","author":"Seeman","year":"2022","journal-title":"IJERPH"},{"issue":"2","key":"2024110900302957300_CIT0032","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41380-021-01339-z","article-title":"Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia","volume":"27","author":"Campeau","year":"2022","journal-title":"Mol Psychiatry."},{"issue":"Suppl 2","key":"2024110900302957300_CIT0033","first-page":"139","article-title":"Cognitive deficit in schizophrenia: an overview","volume":"31","author":"Mihaljevi\u0107-Pele\u0161","year":"2019","journal-title":"Psychiatr Danub."},{"issue":"12","key":"2024110900302957300_CIT0034","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1001\/jamapsychiatry.2015.1737","article-title":"Premature mortality among adults with schizophrenia in the United States","volume":"72","author":"Olfson","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"2024110900302957300_CIT0035","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/YCO.0000000000000530","article-title":"Causes of premature mortality in schizophrenia: a review of literature published in 2018","volume":"32","author":"Laursen","year":"2019","journal-title":"Curr Opin Psychiatry."},{"issue":"4","key":"2024110900302957300_CIT0036","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2215-0366(17)30078-0","article-title":"Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis","volume":"4","author":"Hjorth\u00f8j","year":"2017","journal-title":"The Lancet Psychiatry"},{"issue":"3","key":"2024110900302957300_CIT0037","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/jamapsychiatry.2016.3803","article-title":"Impaired glucose homeostasis in first-episode schizophrenia: a systematic review and meta-analysis","volume":"74","author":"Pillinger","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"2024110900302957300_CIT0038","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12991-017-0134-6","article-title":"Lifestyle factors and the metabolic syndrome in Schizophrenia: a cross-sectional study","volume":"16","author":"Heald","year":"2017","journal-title":"Ann Gen Psychiatry"},{"issue":"2","key":"2024110900302957300_CIT0039","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/schbul\/sbr148","article-title":"Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders\u2014a systematic review and meta-analysis","volume":"39","author":"Mitchell","year":"2013","journal-title":"Schizophr Bull."},{"key":"2024110900302957300_CIT0040","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3389\/fpsyt.2020.00596","article-title":"Polymorphisms in the human aquaporin 4 gene are associated with schizophrenia in the Southern Chinese ham population: a case\u2013control study","volume":"11","author":"Wu","year":"2020","journal-title":"Front Psychiatry."},{"key":"2024110900302957300_CIT0041","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.schres.2019.11.029","article-title":"Symptomatic psychosis risk and physiological fluctuation in functional MRI data","volume":"216","author":"Saarinen","year":"2020","journal-title":"Schizophr Res."},{"issue":"4","key":"2024110900302957300_CIT0042","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1037\/a0029857","article-title":"The natural history of cognitive decline in Alzheimer\u2019s disease","volume":"27","author":"Wilson","year":"2012","journal-title":"Psychol Aging."},{"issue":"9","key":"2024110900302957300_CIT0043","doi-asserted-by":"crossref","first-page":"e73645","DOI":"10.1371\/journal.pone.0073645","article-title":"Cognitive Declines Precede and Predict Functional Declines in Aging and Alzheimer\u2019s Disease. Hashimoto K, ed","volume":"8","author":"Zahodne","year":"2013","journal-title":"PLoS One."},{"issue":"8","key":"2024110900302957300_CIT0044","doi-asserted-by":"crossref","first-page":"e479","DOI":"10.1016\/S2666-7568(21)00140-9","article-title":"Mortality rates in Alzheimer\u2019s disease and non-Alzheimer\u2019s dementias: a systematic review and meta-analysis","volume":"2","author":"Liang","year":"2021","journal-title":"Lancet Healthy Longevity"},{"issue":"1","key":"2024110900302957300_CIT0045","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/156720512799015064","article-title":"Metabolic dysfunction in Alzheimers disease and related neurodegenerative disorders","volume":"9","author":"Cai","year":"2012","journal-title":"CAR"},{"key":"2024110900302957300_CIT0046","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnins.2020.00213","article-title":"Neurodegenerative diseases \u2013 Is metabolic deficiency the root cause","volume":"14","author":"Muddapu","year":"2020","journal-title":"Front Neurosci."},{"issue":"2","key":"2024110900302957300_CIT0047","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/cells11020238","article-title":"Accelerated aging characterizes the early stage of Alzheimer\u2019s disease","volume":"11","author":"Leparulo","year":"2022","journal-title":"Cells"},{"issue":"3","key":"2024110900302957300_CIT0048","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.trci.2017.05.001","article-title":"The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer\u2019s disease","volume":"3","author":"Burfeind","year":"2017","journal-title":"A&D Transl Res & Clin Interv"},{"key":"2024110900302957300_CIT0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2020.06.007","article-title":"Aquaporin-4 polymorphisms predict amyloid burden and clinical outcome in the Alzheimer\u2019s disease spectrum","volume":"97","author":"Chandra","year":"2021","journal-title":"Neurobiol Aging."},{"issue":"2","key":"2024110900302957300_CIT0050","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3233\/JAD-170349","article-title":"Cerebral artery pulsatility is associated with cognitive impairment and predicts dementia in individuals with subjective memory decline or mild cognitive impairment","volume":"60","author":"Chung","year":"2017","journal-title":"JAD"},{"issue":"1","key":"2024110900302957300_CIT0051","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ana.26648","article-title":"Choroid plexus enlargement exacerbates white matter hyperintensity growth through glymphatic impairment","volume":"94","author":"Li","year":"2023","journal-title":"Ann Neurol."},{"issue":"7","key":"2024110900302957300_CIT0052","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1176\/appi.ajp.2019.18070825","article-title":"Association of choroid plexus enlargement with cognitive, inflammatory, and structural phenotypes across the psychosis spectrum","volume":"176","author":"Lizano","year":"2019","journal-title":"Am J Psychiatry."},{"key":"2024110900302957300_CIT0053","article-title":"Investigation of choroid plexus variability in schizophrenia-spectrum disorders \u2013 insights from a multimodal stud","author":"Yakimov","year":"2023"},{"issue":"11","key":"2024110900302957300_CIT0054","first-page":"2058460115609635","article-title":"MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain","volume":"4","author":"Eide","year":"2015","journal-title":"Acta Radiol Open"},{"issue":"1","key":"2024110900302957300_CIT0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2463\/mrms.mp.2016-0039","article-title":"Gd-based contrast enhancement of the perivascular spaces in the Basal Ganglia","volume":"16","author":"Naganawa","year":"2017","journal-title":"Magn Reson Med Sci."},{"issue":"3","key":"2024110900302957300_CIT0056","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00062-019-00845-6","article-title":"Acute encephalopathy and cardiac arrest induced by intrathecal gadolinium administration","volume":"30","author":"Besteher","year":"2020","journal-title":"Clin Neuroradiol"},{"key":"2024110900302957300_CIT0057","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/rapm-2019-100422","article-title":"Fatal gadolinium-induced encephalopathy following accidental intrathecal administration: a case report and a comprehensive evidence-based review","volume":"44","author":"Provenzano","year":"2019","journal-title":"Reg Anesth Pain Med."},{"issue":"9","key":"2024110900302957300_CIT0058","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.crad.2008.02.004","article-title":"Overdosage of intrathecal gadolinium and neurological response","volume":"63","author":"Li","year":"2008","journal-title":"Clin Radiol."},{"issue":"1","key":"2024110900302957300_CIT0059","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1148\/radiol.2020191373","article-title":"Safety of intrathecal administration of gadolinium-based contrast agents: a systematic review and meta-analysis","volume":"297","author":"Patel","year":"2020","journal-title":"Radiology."},{"issue":"5","key":"2024110900302957300_CIT0060","doi-asserted-by":"crossref","first-page":"e4393","DOI":"10.1002\/nbm.4393","article-title":"Contribution of macromolecules to brain 1 H MR spectra: Experts\u2019 consensus recommendations","volume":"34","author":"Cudalbu","year":"2021","journal-title":"NMR Biomed."},{"issue":"2","key":"2024110900302957300_CIT0061","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/mrm.10367","article-title":"Metabolic profiles of human brain tumors using quantitative in vivo 1 H magnetic resonance spectroscopy","volume":"49","author":"Howe","year":"2003","journal-title":"Magnetic Resonance Med"},{"issue":"1","key":"2024110900302957300_CIT0062","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/mrm.10332","article-title":"Parameterized evaluation of macromolecules and lipids in proton MR spectroscopy of brain diseases","volume":"49","author":"Seeger","year":"2003","journal-title":"Magnetic Resonance Med"},{"issue":"5","key":"2024110900302957300_CIT0063","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/brain\/124.5.953","article-title":"Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis","volume":"124","author":"Mader","year":"2001","journal-title":"Brain."},{"issue":"12","key":"2024110900302957300_CIT0064","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1080\/10715760600918142","article-title":"Protein oxidation and aging","volume":"40","author":"Stadtman","year":"2006","journal-title":"Free Radic Res."},{"issue":"2","key":"2024110900302957300_CIT0065","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/schbul\/sbx069","article-title":"Systemic biomarkers of accelerated aging in schizophrenia: a critical review and future directions","volume":"44","author":"Nguyen","year":"2018","journal-title":"Schizophr Bull."},{"key":"2024110900302957300_CIT0066","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2023.04.004","article-title":"Association of cognition and brain reserve in aging and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS)","volume":"524","author":"Hsiao","year":"2023","journal-title":"Neuroscience."},{"issue":"10","key":"2024110900302957300_CIT0067","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1001\/jama.1994.03520100096046","article-title":"DSM-IV: diagnostic and statistical manual of mental disorders","volume":"272","author":"Bell","year":"1994","journal-title":"JAMA."},{"key":"2024110900302957300_CIT0068","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry."},{"issue":"7","key":"2024110900302957300_CIT0069","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.biopsych.2018.09.009","article-title":"Glutamatergic neurometabolite levels in patients with ultra-treatment-resistant schizophrenia: a cross-sectional 3T proton magnetic resonance spectroscopy study","volume":"85","author":"Iwata","year":"2019","journal-title":"Biol Psychiatry."},{"issue":"1","key":"2024110900302957300_CIT0070","doi-asserted-by":"crossref","first-page":"sgab006","DOI":"10.1093\/schizbullopen\/sgab006","article-title":"Glutathione levels and glutathione-glutamate correlation in patients with treatment-resistant schizophrenia","volume":"2","author":"Iwata","year":"2021","journal-title":"Schizophr. Bull. Open."},{"issue":"1","key":"2024110900302957300_CIT0071","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13550-023-01020-2","article-title":"Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex","volume":"13","author":"van Engelen","year":"2023","journal-title":"EJNMMI Res"},{"key":"2024110900302957300_CIT0072","doi-asserted-by":"crossref","first-page":"1035746","DOI":"10.3389\/fnagi.2022.1035746","article-title":"Altered anterior cingulate cortex subregional connectivity associated with cognitions for distinguishing the spectrum of pre-clinical Alzheimer\u2019s disease","volume":"14","author":"Yuan","year":"2022","journal-title":"Front Aging Neurosci."},{"issue":"11","key":"2024110900302957300_CIT0073","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3390\/brainsci12111555","article-title":"Altered Functional connectivity of basal ganglia in mild cognitive impairment and Alzheimer\u2019s disease","volume":"12","author":"Xiong","year":"2022","journal-title":"Brain Sci"},{"key":"2024110900302957300_CIT0074","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fnagi.2017.00143","article-title":"Altered functional connectivity of cognitive-related cerebellar Subregions in Alzheimer\u2019s disease","volume":"9","author":"Zheng","year":"2017","journal-title":"Front Aging Neurosci."},{"issue":"12","key":"2024110900302957300_CIT0075","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1001\/jamapsychiatry.2017.3292","article-title":"Extent of dorsolateral prefrontal cortex plasticity and its association with working memory in patients with Alzheimer disease","volume":"74","author":"Kumar","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"7","key":"2024110900302957300_CIT0076","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/pcn.13557","article-title":"Gray matter reserve determines glymphatic system function in young-onset Alzheimer\u2019s disease: evidenced by DTI-ALPS and compared with age-matched controls","volume":"77","author":"Chang","year":"2023","journal-title":"Psychiatry Clin Neurosci."},{"issue":"3","key":"2024110900302957300_CIT0077","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41386-022-01499-8","article-title":"Working memory processing deficit associated with a nonlinear response pattern of the anterior cingulate cortex in first-episode and drug-na\u00efve schizophrenia","volume":"48","author":"Feng","year":"2023","journal-title":"Neuropsychopharmacology."},{"issue":"4","key":"2024110900302957300_CIT0078","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41591-020-0793-8","article-title":"A neuroimaging biomarker for striatal dysfunction in schizophrenia","volume":"26","author":"Li","year":"2020","journal-title":"Nat Med."},{"issue":"3","key":"2024110900302957300_CIT0079","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/schbul\/sby094","article-title":"Dysconnectivity of large-scale functional networks in early psychosis: a meta-analysis","volume":"45","author":"O\u2019Neill","year":"2019","journal-title":"Schizophr Bull."},{"key":"2024110900302957300_CIT0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41537-019-0087-7","article-title":"Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia","volume":"5","author":"Sekiguchi","year":"2019","journal-title":"npj Schizophr."},{"issue":"11","key":"2024110900302957300_CIT0081","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jamapsychiatry.2017.2663","article-title":"Heterogeneity and homogeneity of regional brain structure in schizophrenia: a meta-analysis","volume":"74","author":"Brugger","year":"2017","journal-title":"JAMA Psychiat"},{"issue":"8","key":"2024110900302957300_CIT0082","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1017\/S0033291714002943","article-title":"Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback","volume":"45","author":"Mucci","year":"2015","journal-title":"Psychol Med."},{"issue":"1","key":"2024110900302957300_CIT0083","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tics.2011.11.015","article-title":"Cognition in schizophrenia: core psychological and neural mechanisms","volume":"16","author":"Barch","year":"2012","journal-title":"Trends Cogn Sci."},{"issue":"5","key":"2024110900302957300_CIT0084","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/schbul\/sbn025","article-title":"Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology","volume":"35","author":"Fornito","year":"2009","journal-title":"Schizophr Bull."},{"issue":"8","key":"2024110900302957300_CIT0085","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1176\/appi.ajp.2008.07060945","article-title":"Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral disorganization, and global function","volume":"165","author":"Yoon","year":"2008","journal-title":"Am J Psychiat."},{"issue":"3","key":"2024110900302957300_CIT0086","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuroimage.2011.02.046","article-title":"A Bayesian model of shape and appearance for subcortical brain segmentation","volume":"56","author":"Patenaude","year":"2011","journal-title":"Neuroimage."},{"issue":"1","key":"2024110900302957300_CIT0087","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.neuroimage.2008.10.055","article-title":"Bayesian analysis of neuroimaging data in FSL","volume":"45","author":"Woolrich","year":"2009","journal-title":"Neuroimage."},{"issue":"4","key":"2024110900302957300_CIT0088","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/nbm.698","article-title":"Automatic quantitation of localized in vivo 1 H spectra with LCModel","volume":"14","author":"Provencher","year":"2001","journal-title":"NMR Biomed."},{"issue":"3","key":"2024110900302957300_CIT0089","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp."},{"key":"2024110900302957300_CIT0090","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","article-title":"An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging","volume":"125","author":"Andersson","year":"2016","journal-title":"Neuroimage."},{"key":"2024110900302957300_CIT0091","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuroimage.2016.06.058","article-title":"Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images","volume":"141","author":"Andersson","year":"2016","journal-title":"Neuroimage."},{"issue":"4","key":"2024110900302957300_CIT0092","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11604-022-01370-2","article-title":"Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset","volume":"41","author":"Tatekawa","year":"2023","journal-title":"Jpn J Radiol"},{"issue":"2","key":"2024110900302957300_CIT0093","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","article-title":"A global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med Image Anal."},{"issue":"2","key":"2024110900302957300_CIT0094","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage."},{"issue":"2","key":"2024110900302957300_CIT0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11604-021-01187-5","article-title":"Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study","volume":"40","author":"Taoka","year":"2022","journal-title":"Jpn J Radiol"},{"issue":"1","key":"2024110900302957300_CIT0096","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1440-1789.1999.00215.x","article-title":"Micro-angiographical studies of the medullary venous system of the cerebral hemisphere","volume":"19","author":"Okudera","year":"1999","journal-title":"Neuropathology"},{"key":"2024110900302957300_CIT0097","author":"Tukey"},{"issue":"4","key":"2024110900302957300_CIT0098","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav Res Methods."},{"issue":"2","key":"2024110900302957300_CIT0099","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull."},{"issue":"3","key":"2024110900302957300_CIT0100","first-page":"63","article-title":"Potential role of amino acids in pathogenesis of schizophrenia","volume":"11","author":"Saleem","year":"2017","journal-title":"Int J Health Sci (Qassim)"},{"key":"2024110900302957300_CIT0101","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.me.32.020181.002213","article-title":"Dietary precursors and brain neurotransmitter formation","volume":"32","author":"Fernstrom","year":"1981","journal-title":"Annu Rev Med."},{"issue":"4","key":"2024110900302957300_CIT0102","first-page":"e23959","article-title":"Neurobiology of schizophrenia: a comprehensive review","volume":"14","author":"Luvsannyam","year":"2022","journal-title":"Cureus"},{"issue":"1","key":"2024110900302957300_CIT0103","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0893-133X(94)00131-I","article-title":"Subanesthetic doses of ketamine stimulate psychosis in schizophrenia","volume":"13","author":"Lahti","year":"1995","journal-title":"Neuropsychopharmacology."},{"issue":"3","key":"2024110900302957300_CIT0104","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/archpsyc.1994.03950030035004","article-title":"Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses","volume":"51","author":"Krystal","year":"1994","journal-title":"Arch Gen Psychiatry."},{"issue":"1","key":"2024110900302957300_CIT0105","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/schbul\/sbr069","article-title":"Glutamate in schizophrenia: a focused review and meta-analysis of 1H-MRS studies","volume":"39","author":"Marsman","year":"2013","journal-title":"Schizophr Bull."},{"issue":"5","key":"2024110900302957300_CIT0106","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1038\/s41380-023-01991-7","article-title":"Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis","volume":"28","author":"Merritt","year":"2023","journal-title":"Mol Psychiatry."},{"issue":"6","key":"2024110900302957300_CIT0107","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/STROKEAHA.115.009090","article-title":"White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden","volume":"46","author":"Charidimou","year":"2015","journal-title":"Stroke."},{"issue":"6","key":"2024110900302957300_CIT0108","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/jnnp-2012-304434","article-title":"Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study","volume":"84","author":"Charidimou","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"24","key":"2024110900302957300_CIT0109","doi-asserted-by":"crossref","first-page":"e2648","DOI":"10.1212\/WNL.0000000000201300","article-title":"Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease","volume":"99","author":"Kamagata","year":"2022","journal-title":"Neurology."},{"issue":"10","key":"2024110900302957300_CIT0110","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s00234-021-02718-7","article-title":"Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology","volume":"63","author":"Gouveia-Freitas","year":"2021","journal-title":"Neuroradiology."},{"issue":"9","key":"2024110900302957300_CIT0111","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/glia.24221","article-title":"Emerging evidence for astrocyte dysfunction in schizophrenia","volume":"70","author":"De Oliveira Figueiredo","year":"2022","journal-title":"Glia."},{"key":"2024110900302957300_CIT0112","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neubiorev.2020.07.038","article-title":"The role of norepinephrine in the pathophysiology of schizophrenia","volume":"118","author":"M\u00e4ki-Marttunen","year":"2020","journal-title":"Neurosci Biobehav Rev."},{"issue":"1","key":"2024110900302957300_CIT0113","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0173(03)00143-7","article-title":"The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes","volume":"42","author":"Berridge","year":"2003","journal-title":"Brain Res Brain Res Rev."},{"issue":"1","key":"2024110900302957300_CIT0114","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41386-019-0444-2","article-title":"Arousal and sleep circuits","volume":"45","author":"Jones","year":"2020","journal-title":"Neuropsychopharmacol"},{"key":"2024110900302957300_CIT0115","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neures.2017.04.008","article-title":"The control of sleep and wakefulness by mesolimbic dopamine systems","volume":"118","author":"Oishi","year":"2017","journal-title":"Neurosci Res."},{"issue":"1","key":"2024110900302957300_CIT0116","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41398-017-0071-9","article-title":"Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience","volume":"8","author":"Kesby","year":"2018","journal-title":"Transl Psychiatry."},{"issue":"8983","key":"2024110900302957300_CIT0117","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S0140-6736(95)91801-9","article-title":"Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients","volume":"346","author":"Hietala","year":"1995","journal-title":"Lancet."},{"issue":"4194","key":"2024110900302957300_CIT0118","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1126\/science.1145194","article-title":"Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons","volume":"188","author":"Seeman","year":"1975","journal-title":"Science."},{"key":"2024110900302957300_CIT0119","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pnpbp.2012.12.021","article-title":"Sleep and circadian rhythm dysregulation in schizophrenia","volume":"43","author":"Monti","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"2024110900302957300_CIT0120","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s11604-023-01463-6","article-title":"Glymphatic system impairment in sleep disruption: diffusion tensor image analysis along the perivascular space (DTI-ALPS)","volume":"41","author":"Saito","year":"2023","journal-title":"Jpn J Radiol"}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/50\/6\/1396\/60543825\/sbae060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/50\/6\/1396\/60543825\/sbae060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T19:32:26Z","timestamp":1731094346000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article\/50\/6\/1396\/7674175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":120,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,5,15]]},"published-print":{"date-parts":[[2024,11,8]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbae060","relation":{},"ISSN":["0586-7614","1745-1701"],"issn-type":[{"value":"0586-7614","type":"print"},{"value":"1745-1701","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,5,15]]}}}