{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:55:55Z","timestamp":1792274155405,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Royal Australia New Zealand College of Psychiatrists"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2013829"],"award-info":[{"award-number":["APP2013829"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2008612"],"award-info":[{"award-number":["APP2008612"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rainbow Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Hypothesis<\/jats:title>\n                  <jats:p>There is mounting evidence that cardiac interoception, the perception of one\u2019s heartbeat, is central to affective experiences. It has been proposed that symptoms of psychosis could arise from interoceptive dysfunction. Here we hypothesized that people with psychotic disorders would have a specific impairment in cardiac interoception, over and above broader perceptual deficits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>43 adults with a history of psychosis (31 schizophrenia, 12 schizoaffective disorder) and 41 matched control participants completed a heart rate discrimination task. Participants responded to whether they perceived a sequence of auditory tones to be faster or slower than their heart rate. By trialing a range of auditory tone rates, we estimated a threshold for each participant, the difference between perceived heart rate and actual heart rate. To test whether differences were specific to interoception, participants completed an exteroceptive control condition, testing their discrimination of the rate of 2 sets of audible sounds instead of heart rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>Participants with a history of psychosis had greater absolute differences between perceived and actual heart rate, indicating over- or under-estimation of heart rate compared to healthy controls. This difference was specific to the interoceptive condition, and not explained by group differences in exteroceptive perception.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Psychotic disorders are associated with misestimation of heart rate. Further research may elucidate whether interoceptive abnormalities contribute to specific symptoms such as somatic delusions or affective features, and whether interoception could be a treatment target in psychotic disorders.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbae078","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T18:10:46Z","timestamp":1716574246000},"page":"208-216","source":"Crossref","is-referenced-by-count":23,"title":["Aberrant Cardiac Interoception in Psychosis"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-918X","authenticated-orcid":false,"given":"Jayson","family":"Jeganathan","sequence":"first","affiliation":[{"name":"School of Psychology, College of Engineering, Science and the Environment, University of Newcastle , Newcastle, NSW,","place":["Australia"]},{"name":"Hunter Medical Research Institute , Newcastle, NSW,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E J","family":"Campbell","sequence":"additional","affiliation":[{"name":"School of Psychology, College of Engineering, Science and the Environment, University of Newcastle , Newcastle, NSW,","place":["Australia"]},{"name":"Hunter Medical Research Institute , Newcastle, NSW,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Legrand","sequence":"additional","affiliation":[{"name":"School of Culture and Society, Interacting Minds Centre, Aarhus University , Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah","family":"Allen","sequence":"additional","affiliation":[{"name":"Center of Functionally Integrative Neuroscience, Aarhus University , Aarhus ,","place":["Denmark"]},{"name":"Department of Psychiatry, University of Cambridge , Cambridge ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Breakspear","sequence":"additional","affiliation":[{"name":"School of Psychology, College of Engineering, Science and the Environment, University of Newcastle , Newcastle, NSW,","place":["Australia"]},{"name":"Hunter Medical Research Institute , Newcastle, NSW,","place":["Australia"]},{"name":"School of Medicine and Public Health, College of Medicine, Health and Wellbeing, University of Newcastle , Newcastle, NSW,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"issue":"8","key":"2024122104071884700_CIT0001","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/nrn894","article-title":"How do you feel? 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