{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:40:07Z","timestamp":1791610807707,"version":"4.3.4"},"reference-count":75,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Hypothesis<\/jats:title>\n                  <jats:p>Substance use is highly prevalent among people with schizophrenia (SCZ) and related disorders, however, there is no broad-spectrum pharmacotherapy that concurrently addresses both addiction and psychotic symptoms. Psychosocial (PS) interventions, which have yielded promising results in treating psychosis and substance dependence separately, demonstrate potential but have not been systematically evaluated when combined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>Systematic review and random-effects meta-analyses of randomized controlled trials (RCTs) investigating PS interventions for individuals with comorbid substance use and psychotic disorders, encompassing SCZ and schizophrenia spectrum disorders (SSD). We included relevant studies published from MEDLINE, PsycINFO, and Google Scholar through May 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>We included 35 RCTs (5176 participants total; approximately 2840 with SSD). Intervention durations ranged from 30\u00a0min to 3 years. Meta-analysis did not identify a statistically significant pooled PS intervention effect on the main primary outcome, substance use (18 studies; 803 intervention, 733 control participants; standardized mean difference, \u22120.05 standard deviation [SD]; 95% CI, \u22120.16, 0.07 SD; I2\u2005=\u200518%). PS intervention effects on other outcomes were also not statistically significant. Overall GRADE certainty of evidence was low.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>At present, the literature lacks sufficient evidence supporting the use of PS interventions as opposed to alternative therapeutic approaches for significantly improving substance use, symptomatology, or functioning in people with SCZ and related disorders. However, firm conclusions were precluded by low certainty of evidence. Further RCTs are needed to determine the efficacy of PS treatments for people with dual-diagnoses (DD), either alone or in combination with pharmacotherapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbae101","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T08:33:18Z","timestamp":1719563598000},"source":"Crossref","is-referenced-by-count":22,"title":["Psychosocial Interventions for Individuals With Comorbid Psychosis and Substance Use Disorders: Systematic Review and Meta-analysis of Randomized Studies"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2414-3521","authenticated-orcid":false,"given":"Salsabil","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto ,\u00a0 Canada"},{"name":"Centre for Addiction and Mental Health (CAMH) , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhvani","family":"Mehta","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto ,\u00a0 Canada"},{"name":"Centre for Addiction and Mental Health (CAMH) , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Coles","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH) , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-2996","authenticated-orcid":false,"given":"Peter","family":"Selby","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, University of Toronto , Toronto , Canada"},{"name":"Department of Psychiatry, University of Toronto , Toronto , Canada"},{"name":"Dalla Lana School of Public Health , Toronto , Canada"},{"name":"Institute of Mental Health Policy Research, Campbell Family Research Institute, CAMH ,\u00a0 Toronto , Canada"},{"name":"Institute of Mental Health Policy and Research, Addictions Division, Integrated Nicotine and Tobacco Research, Education, Programming, Implementation and Digital Health (INTREPID) Lab, CAMH , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-7233","authenticated-orcid":false,"given":"Marco","family":"Solmi","sequence":"additional","affiliation":[{"name":"SCIENCES Lab, Department of Psychiatry, University of Ottawa , Ottawa, Ontario , Canada"},{"name":"Regional Centre for the Treatment of Eating Disorders and On Track: The Champlain First Episode Psychosis Program, Department of Mental Health, The Ottawa Hospital , Ottawa, Ontario , Canada"},{"name":"Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program, University of Ottawa , Ottawa, Ontario , Canada"},{"name":"Department of Child and Adolescent Psychiatry, Charit\u00e9 Universit\u00e4tsmedizin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Castle","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto , Toronto ,\u00a0 Canada"},{"name":"Department of Psychiatry, University of Tasmania , Hobart ,\u00a0 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"issue":"6","key":"2024062808320976800_CIT0001","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1192\/bja.2019.33","article-title":"Tobacco smoking and schizophrenia: re-examining the evidence","volume":"25","author":"Isuru","year":"2019","journal-title":"BJPsych Adv."},{"issue":"3","key":"2024062808320976800_CIT0002","doi-asserted-by":"crossref","first-page":"e234995","DOI":"10.1001\/jamanetworkopen.2023.4995","article-title":"Tobacco use, 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