{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:55:15Z","timestamp":1789095315759,"version":"build-2803163510"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Capital Health Research and Development of Special","award":["2022-1-2131"],"award-info":[{"award-number":["2022-1-2131"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171507"],"award-info":[{"award-number":["82171507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High level public health talents\u2014leading talents project","award":["2024"],"award-info":[{"award-number":["2024"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH112180"],"award-info":[{"award-number":["R01MH112180"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Hypothesis<\/jats:title>\n                  <jats:p>Sensory gating deficit is considered a pathophysiological feature of schizophrenia, which has been linked to N-methyl-d-aspartate receptor (NMDAR) hypofunction as one of the potential underlying mechanisms. Here, we hypothesize that higher levels of NMDAR antibody (Ab) may contribute to the sensory gating deficits in schizophrenia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>We enrolled 72 non-smoking inpatients with first-episode schizophrenia (FES), most of them with only a relatively short duration of exposure to antipsychotic medications, and 51 non-smoking healthy controls (HC). Sensory gating was measured by P50 evoked potentials ratio and the difference between the two stimuli in an auditory paired-stimuli paradigm and serum NMDAR Ab levels were quantified by enzyme-linked immunosorbent assay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>The FES group showed higher serum NMDAR Ab levels [(9.23\u2005\u00b1\u20054.15) ng\/mL vs. (7.08\u2005\u00b1\u20052.83) ng\/mL; P\u2005=\u2005.002], higher P50 ratio (P\u2005=\u2005.002), and less P50 difference (P\u2005=\u2005.001) than HC. In partial correlation analysis, serum NMDAR Ab levels were positively correlated with the P50 ratio (r\u2005=\u20050.36, P\u2005=\u2005.003) and negatively with the P50 difference (r\u2005=\u2005\u22120.39, P\u2005=\u2005.001) in the FES group. The NMDAR Ab levels mediated the diagnosis of schizophrenia and P50 sensory gating deficits (P50 ratio and P50 difference).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Autoimmunity targeting NMDAR is a crucial intermediate mechanism in impaired sensory gating in patients with schizophrenia. The findings support early intervention targeting NMDAR for patients with schizophrenia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbae180","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:20:58Z","timestamp":1729038058000},"page":"1072-1081","source":"Crossref","is-referenced-by-count":3,"title":["<i>N<\/i>-Methyl-<scp>d<\/scp>-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia"],"prefix":"10.1093","volume":"51","author":[{"given":"Jinghui","family":"Tong","sequence":"first","affiliation":[{"name":"Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital , Beijing 100096 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kebing","family":"Yang","sequence":"additional","affiliation":[{"name":"Peking University HuiLongGuan Clinical Medical School, Beijing 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