{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:01:11Z","timestamp":1775286071763,"version":"3.50.1"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mental Health Services of the Capital Region of Denmark"},{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research"},{"name":"Tryg Foundation and the Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is known that impairments in linguistic ability and motor function tend to co-occur in children, and that children from families with parental mental illness such as schizophrenia tend to perform poorly in both domains, but the exact nature of these links has not yet been fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>In this study, we leveraged the first wave of the Danish High Risk and Resilience Study (VIA 7), which includes both genetic data and measures covering multiple developmental domains. The VIA 7 cohort comprises 522 7-year-old children born to parents with schizophrenia (N\u2005=\u2005202), bipolar disorder (N\u2005=\u2005120) or neither (N\u2005=\u2005200). We investigated the relationships between linguistic ability and motor function using correlation and regression analyses, focusing on developmental coordination disorder (DCD) and specific language impairment (SLI) and their potential associations with the three risk groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found significant correlations between most measures of language and motor function and significant associations of DCD and SLI with language and movement measures, respectively, the largest effect being that of DCD on receptive language, with a significant interaction effect: DCD was associated with poorer performance in children from schizophrenia families compared to bipolar disorder and control families. Both disorders showed higher prevalence among children with familial high risk of mental illness. We did not find significant evidence of genetic overlap between DCD and SLI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest strong links between the domains of motor function and linguistic ability. Children of parents with schizophrenia are at high risk of comorbid language and movement disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbae181","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T15:23:33Z","timestamp":1728660213000},"page":"1555-1567","source":"Crossref","is-referenced-by-count":3,"title":["Language, Motor Ability and Related Deficits in Children at Familial Risk of Schizophrenia or Bipolar Disorder"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6114-6914","authenticated-orcid":false,"given":"Marta","family":"Schiavon","sequence":"first","affiliation":[{"name":"CORE\u2013Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital , 2900 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte K","family":"Burton","sequence":"additional","affiliation":[{"name":"CORE\u2013Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital , 2900 Copenhagen ,","place":["Denmark"]},{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-9981","authenticated-orcid":false,"given":"Nicoline","family":"Hemager","sequence":"additional","affiliation":[{"name":"CORE\u2013Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital , 2900 Copenhagen ,","place":["Denmark"]},{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"Mental Health Center for Child and Adolescent Psychiatry\u2013Research unit, Mental Health Services in the Capital Region of Denmark , 2900 Copenhagen ,","place":["Denmark"]},{"name":"University of Copenhagen Department of Psychology, , 1357 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-6639","authenticated-orcid":false,"given":"Aja N","family":"Greve","sequence":"additional","affiliation":[{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"Psychosis Research Unit, Department of Clinical Medicine, Aarhus University Hospital\u2013Psychiatry , 8200 Aarhus ,","place":["Denmark"]},{"name":"Faculty of Health, 8200 Aarhus University Department of Clinical Medicine, , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine S","family":"Spang","sequence":"additional","affiliation":[{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"Mental Health Center for Child and Adolescent Psychiatry\u2013Research unit, Mental Health Services in the Capital Region of Denmark , 2900 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte","family":"Ellersgaard","sequence":"additional","affiliation":[{"name":"CORE\u2013Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital , 2900 Copenhagen ,","place":["Denmark"]},{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin Jessica","family":"Plessen","sequence":"additional","affiliation":[{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"Mental Health Center for Child and Adolescent Psychiatry\u2013Research unit, Mental Health Services in the Capital Region of Denmark , 2900 Copenhagen ,","place":["Denmark"]},{"name":"Division of Child and Adolescent Psychiatry, Hospital University Lausanne and Lausanne University Department of Psychiatry, , 1004 Lausanne ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Richardt M","family":"Jepsen","sequence":"additional","affiliation":[{"name":"CORE\u2013Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital , 2900 Copenhagen ,","place":["Denmark"]},{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"Mental Health Center for Child and Adolescent Psychiatry\u2013Research unit, Mental Health Services in the Capital Region of Denmark , 2900 Copenhagen ,","place":["Denmark"]},{"name":"Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Services in the Capital Region of Denmark , 2600 Glostrup ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne A E","family":"Thorup","sequence":"additional","affiliation":[{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"Mental Health Center for Child and Adolescent Psychiatry\u2013Research unit, Mental Health Services in the Capital Region of Denmark , 2900 Copenhagen ,","place":["Denmark"]},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen Department of Clinical Medicine, , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Werge","sequence":"additional","affiliation":[{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen Department of Clinical Medicine, , 2200 Copenhagen ,","place":["Denmark"]},{"name":"Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen , 4000 Roskilde ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete","family":"Nordentoft","sequence":"additional","affiliation":[{"name":"CORE\u2013Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital , 2900 Copenhagen ,","place":["Denmark"]},{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"University of Copenhagen Department of Psychology, , 1357 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-011X","authenticated-orcid":false,"given":"Ron","family":"Nudel","sequence":"additional","affiliation":[{"name":"CORE\u2013Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital , 2900 Copenhagen ,","place":["Denmark"]},{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , 8210 Aarhus ,","place":["Denmark"]},{"name":"Copenhagen Research Center for Biological and Precision Psychiatry, Mental Health Centre Copenhagen, Copenhagen University Hospital , 2900 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"2025111023424662000_CIT0001","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1365-2214.2012.01379.x","article-title":"Quality of life domains affected in children with developmental coordination disorder: a systematic review. 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