{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:46:40Z","timestamp":1790999200353,"version":"4.1.0"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["82001407"],"award-info":[{"award-number":["82001407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["U22A20304"],"award-info":[{"award-number":["U22A20304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["82171498"],"award-info":[{"award-number":["82171498"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation","award":["232300421190"],"award-info":[{"award-number":["232300421190"]}]},{"name":"Youth Project of Medical Science and Technology","award":["SBGJ202103094"],"award-info":[{"award-number":["SBGJ202103094"]}]},{"name":"Science and Technology Project","award":["GG2021035"],"award-info":[{"award-number":["GG2021035"]}]},{"name":"College Students\u2019 Innovative Entrepreneurial Training Plan Program","award":["202310472005"],"award-info":[{"award-number":["202310472005"]}]},{"name":"Open Project of Henan Key Laboratory of Biological Psychiatry","award":["ZDSYS2022002"],"award-info":[{"award-number":["ZDSYS2022002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Hypothesis<\/jats:title>\n                  <jats:p>The complex immune-brain interactions and the regulatory role of mitochondria in the immune response suggest that mitochondrial damage reported in schizophrenia (SZ) may be related to abnormalities observed in immune and brain functions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>Mitochondrial DNA copy number (mtDNA CN), a biomarker of mitochondrial function, was assessed in peripheral blood leukocytes (PBLs) of 121 healthy individuals and 118 SZ patients before and after 8 weeks of antipsychotic treatment, and a meta-analysis related to blood mtDNA CN was conducted. Plasma C-reactive protein (CRP) levels in SZ patients were obtained from the medical record system. Spearman correlation analysis and hierarchical linear regression were used to analyze the relationships among mtDNA CN, CRP levels, and cognitive function. A mediation model was constructed using the PROCESS program.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>Our results revealed the decreased mtDNA CN in PBLs from SZ patients (P\u2005=\u2005.05). The meta-analysis supported the decreased blood mtDNA CN in SZ patients (P\u2005&amp;lt;\u2005.01). The mtDNA CN in PBL was positively correlated with working memory (P\u2005=\u2005.02) and negatively correlated with plasma CRP levels (P\u2005=\u2005.039). Furthermore, a lower mtDNA CN in PBL in SZ patients was a significant predictor of worse working memory (P\u2005=\u2005.006). CRP acted as a mediator with an 8.0% effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study revealed an association between peripheral mitochondrial dysfunction and cognitive impairment in SZ, with inflammation acting as a mediating effect. Therefore, mitochondrial dysfunction might provide novel targets for new treatments for cognitive impairment in SZ.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbae196","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T17:51:32Z","timestamp":1731520292000},"page":"1092-1103","source":"Crossref","is-referenced-by-count":11,"title":["Mitochondrial Dysfunction and Cognitive Impairment in Schizophrenia: The Role of Inflammation"],"prefix":"10.1093","volume":"51","author":[{"given":"Guanyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University , Xinxiang 453002 ,","place":["China"]},{"name":"Henan Key Lab of Biological Psychiatry, Xinxiang Medical University , Xinxiang 453002 ,","place":["China"]},{"name":"International Joint Research Laboratory for Psychiatry and Neuroscience of Henan , Xinxiang 453002 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