{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T17:38:34Z","timestamp":1768671514844,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Science Fund China","award":["82171500"],"award-info":[{"award-number":["82171500"]}]},{"name":"Key Program of Beijing Science and Technology Commission","award":["D171100007017002"],"award-info":[{"award-number":["D171100007017002"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2018-4-4116"],"award-info":[{"award-number":["2018-4-4116"]}]},{"name":"Nanjing Medical University Science and Technology Development Fund","award":["NMUB20220135"],"award-info":[{"award-number":["NMUB20220135"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the relationships between baseline peptide antigen-related IgG levels and 8-week antipsychotic drug (APD) treatment response rates and one-year treatment outcomes, as well as the relationships between changes in peptide antigen-related IgG levels and one-year treatment outcomes, in first-episode schizophrenia (FES) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen peptide antigen-related IgGs from proteins encoded by schizophrenia-related genes were selected on the basis of several selection criteria from a 2022 genome-wide association study. Novel peptide antigen-related IgG levels were measured in drug-na\u00efve FES patients at baseline (n\u2005=\u2005155) and in plasma samples from 60 healthy controls (HCs). At the one-year follow-up, 57 patients completed both symptom and autoantibody assessments. Statistical analyses included t tests, Pearson correlation analysis, linear regression analysis, linear mixed-effects models, and simple slope analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anti-MOB4 IgG and anti-PDIA3 IgG levels were significantly lower in drug-na\u00efve FES patients compared to HCs and showed a negative correlation with baseline excitement factor scores. Baseline anti-EMB IgG levels were associated with the 8-week treatment response, whereas anti-MAD1L1 IgG levels were correlated with one-year outcomes in drug-na\u00efve FES patients. The one-year trajectory of changes in anti-FURIN IgG, anti-MAPK3 IgG, and anti-ACTR1B IgG levels was related to remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study revealed that patients with schizophrenia had autoimmune abnormalities, with different peptide antigen-related IgG being associated with short-term or long-term treatment efficacy, and that these antibody levels were regulated by APDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbae199","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T07:28:58Z","timestamp":1732260538000},"source":"Crossref","is-referenced-by-count":0,"title":["Association Between Peptide Antigen-Related Antibody Levels and the Short- and Long-Term Efficacy of Antipsychotic Treatment in Drug-Na\u00efve First-Episode Schizophrenia Patients"],"prefix":"10.1093","volume":"52","author":[{"given":"Yue","family":"Zheng","sequence":"first","affiliation":[{"name":"Clinical Research Department,\u00a0Peking University Sixth Hospital, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) , Beijing 100191 ,","place":["China"]},{"name":"Clinical Research Department,\u00a0Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University) , Beijing 100191 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Psychiatry,\u00a0Nanjing Brain Hospital affiliated to Nanjing Medical University , Nanjing 210029, Jiangsu ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqia","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Department,\u00a0Peking University Sixth Hospital, National 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