{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:45:47Z","timestamp":1787849147646,"version":"build-2784847793"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH121411"],"award-info":[{"award-number":["R01MH121411"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VA CSR&D Senior Research Career Scientist","award":["IK6 CX002700"],"award-info":[{"award-number":["IK6 CX002700"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The etiology of schizophrenia involves both biological and environmental risk factors. Studying childhood trauma in disorders along the schizophrenia spectrum, including schizotypal personality disorder (SPD), can inform early risk and protective factors for psychosis. However, no study has directly compared childhood trauma between SPD and schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>One hundred twenty-four participants (schizophrenia\/schizoaffective disorder [SZ] n\u2005=\u200545, SPD n\u2005=\u200532, and healthy controls [HCs] n\u2005=\u200547) matched on age and gender were assessed for different types of childhood abuse and neglect as well as clinical symptoms. Kruskal-Wallis H-tests examined group differences in childhood trauma severity and logistic regression modeled childhood trauma types that were associated with an SZ vs SPD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>SZ and SPD had greater severity than HC on total trauma score and all types of childhood trauma assessed (all P-values\u2005&amp;lt;\u2005.05). SZ and SPD only differed on childhood sexual abuse, which was greater in SZ (P\u2005=\u2005.039). Childhood sexual abuse (odds ratio [OR]\u2005=\u20051.14, 95% confidence interval [CI]\u2005=\u20051.02-1.27, P\u2005=\u2005.02) and emotional abuse (OR\u2005=\u20050.82, 95% CI\u2005=\u20050.71-0.95, P\u2005=\u2005.01) were independent predictors of an SZ vs SPD diagnosis. Sensitivity analysis indicated that a cutoff at mild sexual abuse was significant in predicting SZ vs SPD when compared with none\/minimal sexual abuse. In SZ, greater sexual abuse was associated with positive schizotypal traits and in SPD, greater emotional abuse was associated with depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings suggest that childhood sexual and emotional abuse may be important factors that influence illness trajectory across the severity of disorders on schizophrenia spectrum. These findings have implications for understanding disease mechanisms and early prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbae209","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T23:21:40Z","timestamp":1732317700000},"source":"Crossref","is-referenced-by-count":4,"title":["Childhood Trauma Across the Schizophrenia Spectrum: A Comparison of Schizotypal Personality Disorder and Schizophrenia"],"prefix":"10.1093","volume":"52","author":[{"given":"Chi C","family":"Chan","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Department of Psychiatry, ,\u00a0 New York, NY 10029 ,\u00a0","place":["United States"]},{"name":"VISN 2 Mental Illness Research, Education, and Clinical Center, James J. 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