{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:18:48Z","timestamp":1791569928084,"version":"4.3.4"},"reference-count":126,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471959"],"award-info":[{"award-number":["82471959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8212018014"],"award-info":[{"award-number":["8212018014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82441007"],"award-info":[{"award-number":["82441007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC2009901"],"award-info":[{"award-number":["2022YFC2009901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC2009900"],"award-info":[{"award-number":["2022YFC2009900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2024NSFSC1794"],"award-info":[{"award-number":["2024NSFSC1794"]}]},{"name":"Sichuan Science and Technology Program","award":["2021JDTD0002"],"award-info":[{"award-number":["2021JDTD0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Hypothesis<\/jats:title>\n                  <jats:p>Identifying biomarkers at onset and specifying the progression over the early course of schizophrenia is critical for better understanding of illness pathophysiology and providing novel information relevant to illness prognosis and treatment selection. Studies of antipsychotic-na\u00efve first-episode schizophrenia in China are making contributions to this goal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>A review was conducted for how antipsychotic-na\u00efve first-episode patients were identified and studied, the investigated biological measures, with a focus on neuroimaging, and how they extend the understanding of schizophrenia regarding the illness-related brain abnormality, treatment effect characterization and outcome prediction, and subtype discovery and patient stratification, in comparison to findings from western populations. Finally, how biomarker studies should be conducted in the future was also discussed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Results<\/jats:title>\n                  <jats:p>Gray matter reduction has been most robust within temporo-frontal regions and cerebellum, whereas altered brain function has been most pronounced in cerebello-cortical connections and default mode network, each might be related to long-standing illness alterations and acute physiological alterations at measurement. By studying untreated patients, the progressive alterations in temporal and frontal regions and enlargements in bilateral putamen were found more likely effects of illness, not just treatment. Some of these changes were found with potential to predict clinical outcomes and differentiate biologically patient subgroups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Mostly with data-driven approaches, the studies from China are helping identify candidate imaging biomarkers in schizophrenia that are related to early-stage illness, treatment effects, and biological subgroup differentiation. Future work is needed to translate these biomarkers for clinical application.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf002","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T04:16:45Z","timestamp":1735877805000},"page":"379-391","source":"Crossref","is-referenced-by-count":17,"title":["Imaging Biomarker Studies of Antipsychotic-Na\u00efve First-Episode Schizophrenia in China: Progress and Future Directions"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-3948","authenticated-orcid":false,"given":"Wenjing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjian","family":"Qiu","sequence":"additional","affiliation":[{"name":"Mental Health Center, West China Hospital, Sichuan University, Sichuan Clinical Medical Research Center for Mental Disorders , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-1769","authenticated-orcid":false,"given":"Su","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"2025031503121059400_CIT0001","doi-asserted-by":"crossref","first-page":"271","DOI":"10.31887\/DCNS.2010.12.3\/ajablensky","article-title":"The diagnostic concept of schizophrenia: its history, evolution, and future prospects","volume":"12","author":"Jablensky","year":"2010","journal-title":"Dialogues Clin Neurosci."},{"key":"2025031503121059400_CIT0002","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.4190","article-title":"The search for imaging biomarkers in psychiatric disorders","volume":"22","author":"Abi-Dargham","year":"2016","journal-title":"Nat Med."},{"key":"2025031503121059400_CIT0003","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1176\/appi.ajp.2015.15050641","article-title":"A selective review of cerebral abnormalities in patients with first-episode schizophrenia before and after treatment","volume":"173","author":"Gong","year":"2016","journal-title":"Am J Psychiatry."},{"key":"2025031503121059400_CIT0004","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1176\/appi.ajp.21070686","article-title":"Schizophrenia imaging signatures and their associations with cognition, psychopathology, and genetics in the general population","volume":"179","author":"Chand","year":"2022","journal-title":"Am J Psychiatry."},{"key":"2025031503121059400_CIT0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/wps.20087","article-title":"The RDoC framework: facilitating transition from ICD\/DSM to dimensional approaches that integrate neuroscience and psychopathology","volume":"13","author":"Cuthbert","year":"2014","journal-title":"World Psychiatry"},{"key":"2025031503121059400_CIT0006","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s44220-023-00019-x","article-title":"Biological subtyping of psychiatric syndromes as a pathway for advances in drug discovery and personalized medicine","volume":"1","author":"Zhang","year":"2023","journal-title":"Nature Mental Health"},{"key":"2025031503121059400_CIT0007","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMp1500523","article-title":"A new initiative on precision medicine","volume":"372","author":"Collins","year":"2015","journal-title":"N Engl J Med."},{"key":"2025031503121059400_CIT0008","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1001\/jama.2015.3595","article-title":"The precision medicine initiative: a new national effort","volume":"313","author":"Ashley","year":"2015","journal-title":"JAMA."},{"key":"2025031503121059400_CIT0009","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1176\/appi.ajp.2008.08020183","article-title":"Association of cerebral deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study","volume":"166","author":"Lui","year":"2009","journal-title":"Am J Psychiatry."},{"key":"2025031503121059400_CIT0010","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1176\/appi.ajp.2013.12091148","article-title":"Anatomical and functional brain abnormalities in drug-naive first-episode schizophrenia","volume":"170","author":"Ren","year":"2013","journal-title":"Am J Psychiatry."},{"key":"2025031503121059400_CIT0011","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/schbul\/sbt177","article-title":"Altered cortical thickness related to clinical severity but not the untreated disease duration in schizophrenia","volume":"41","author":"Xiao","year":"2015","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0012","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10334-013-0411-6","article-title":"Association of white matter deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized VBM study using 3T","volume":"27","author":"Yao","year":"2014","journal-title":"MAGMA."},{"key":"2025031503121059400_CIT0013","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1016\/j.neuroimage.2009.11.072","article-title":"Localization of cerebral functional deficits in treatment-naive, first-episode schizophrenia using resting-state fMRI","volume":"49","author":"Huang","year":"2010","journal-title":"Neuroimage."},{"key":"2025031503121059400_CIT0014","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.schres.2018.08.005","article-title":"Dissociation of fractional anisotropy and resting-state functional connectivity alterations in antipsychotic-naive first-episode schizophrenia","volume":"204","author":"Liu","year":"2019","journal-title":"Schizophr Res."},{"key":"2025031503121059400_CIT0015","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/schbul\/sbx048","article-title":"Altered white matter connectivity within and between networks in antipsychotic-naive first-episode schizophrenia","volume":"44","author":"Li","year":"2018","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0016","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41398-018-0350-0","article-title":"Dysconnectivity of the medio-dorsal thalamic nucleus in drug-na\u00efve first-episode schizophrenia: diagnosis-specific or trans-diagnostic effect","volume":"9","author":"Gong","year":"2019","journal-title":"Transl Psychiatry."},{"key":"2025031503121059400_CIT0017","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.schres.2015.07.031","article-title":"Dysfunctional resting-state connectivities of brain regions with structural deficits in drug-naive first-episode schizophrenia adolescents","volume":"168","author":"Zhang","year":"2015","journal-title":"Schizophr Res."},{"key":"2025031503121059400_CIT0018","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.schres.2014.07.051","article-title":"Decreased gray matter volume in the left middle temporal gyrus as a candidate biomarker for schizophrenia: a study of drug-naive, first-episode schizophrenia patients and unaffected siblings","volume":"159","author":"Guo","year":"2014","journal-title":"Schizophr Res."},{"key":"2025031503121059400_CIT0019","doi-asserted-by":"crossref","first-page":"14505","DOI":"10.1038\/srep14505","article-title":"Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: a volumetric MRI study","volume":"5","author":"Huang","year":"2015","journal-title":"Sci Rep."},{"key":"2025031503121059400_CIT0020","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-024-02021-y","article-title":"Improved patient identification by incorporating symptom severity in deep learning using neuroanatomic images in first-episode schizophrenia","author":"Zhang","year":"2024","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0021","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-024-02485-9","article-title":"Altered temporal lobe connectivity is associated with psychotic symptoms in drug-na\u00efve adolescent patients with first-episode schizophrenia","author":"Li","year":"2024","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"2025031503121059400_CIT0022","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.nicl.2018.06.018","article-title":"Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations","volume":"19","author":"Zhang","year":"2018","journal-title":"Neuroimage Clin."},{"key":"2025031503121059400_CIT0023","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pscychresns.2016.09.011","article-title":"The structural connectivity pathology of first-episode schizophrenia based on the cardinal symptom of auditory verbal hallucinations","volume":"257","author":"Xi","year":"2016","journal-title":"Psychiatry Res Neuroimaging"},{"key":"2025031503121059400_CIT0024","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.schres.2016.02.039","article-title":"Putamen-related regional and network functional deficits in first-episode schizophrenia with auditory verbal hallucinations","volume":"173","author":"Cui","year":"2016","journal-title":"Schizophr Res."},{"key":"2025031503121059400_CIT0025","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12264-017-0101-x","article-title":"Abnormal effective connectivity in the brain is involved in auditory verbal hallucinations in schizophrenia","volume":"33","author":"Li","year":"2017","journal-title":"Neurosci Bull."},{"key":"2025031503121059400_CIT0026","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1148\/radiol.2016160938","article-title":"Disturbed brain activity in resting-state networks of patients with first-episode schizophrenia with auditory verbal hallucinations: a cross-sectional functional MR imaging study","volume":"283","author":"Cui","year":"2017","journal-title":"Radiology."},{"key":"2025031503121059400_CIT0027","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.schres.2017.01.024","article-title":"Resting-state functional connectivity in medication-na\u00efve schizophrenia patients with and without auditory verbal hallucinations: a preliminary report","volume":"188","author":"Chang","year":"2017","journal-title":"Schizophr Res."},{"key":"2025031503121059400_CIT0028","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/schbul\/sbs129","article-title":"Neurophysiological evidence of corollary discharge function during vocalization in psychotic patients and their nonpsychotic first-degree relatives","volume":"39","author":"Ford","year":"2013","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0029","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1017\/S135561770065508X","article-title":"How hallucinations may arise from brain mechanisms of learning, attention, and volition","volume":"6","author":"Grossberg","year":"2000","journal-title":"J Int Neuropsychol Soc."},{"key":"2025031503121059400_CIT0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1176\/appi.ajp.2008.08111685","article-title":"Connecting brain structure and function in schizophrenia","volume":"166","author":"Tregellas","year":"2009","journal-title":"Am J Psychiatry."},{"key":"2025031503121059400_CIT0031","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1503\/jpn.160219","article-title":"Association between structural and functional brain alterations in drug-free patients with schizophrenia: a multimodal meta-analysis","volume":"43","author":"Gao","year":"2018","journal-title":"J Psychiatry Neurosci."},{"key":"2025031503121059400_CIT0032","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1017\/S0033291716002683","article-title":"Common pattern of gray-matter abnormalities in drug-naive and medicated first-episode schizophrenia: a multimodal meta-analysis","volume":"47","author":"Shah","year":"2017","journal-title":"Psychol Med."},{"key":"2025031503121059400_CIT0033","doi-asserted-by":"crossref","first-page":"593703","DOI":"10.3389\/fpsyt.2021.593703","article-title":"The effects of antipsychotic treatment on the brain of patients with first-episode schizophrenia: a selective review of longitudinal MRI studies","volume":"12","author":"Yang","year":"2021","journal-title":"Front Psychiatry."},{"key":"2025031503121059400_CIT0034","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/0004867414554268","article-title":"Regional white matter abnormalities in drug-naive, first-episode schizophrenia patients and their healthy unaffected siblings","volume":"49","author":"Lyu","year":"2015","journal-title":"Aust N Z J Psychiatry."},{"key":"2025031503121059400_CIT0035","doi-asserted-by":"crossref","first-page":"e1493","DOI":"10.1097\/MD.0000000000001493","article-title":"Increased causal connectivity related to anatomical alterations as potential endophenotypes for schizophrenia","volume":"94","author":"Guo","year":"2015","journal-title":"Medicine (Baltim)."},{"key":"2025031503121059400_CIT0036","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/schbul\/sbp151","article-title":"Cortical thickness reduction in individuals at ultra-high-risk for psychosis","volume":"37","author":"Jung","year":"2011","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0037","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1001\/archgenpsychiatry.2009.12","article-title":"Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis","volume":"66","author":"Takahashi","year":"2009","journal-title":"Arch Gen Psychiatry."},{"key":"2025031503121059400_CIT0038","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.neuroimage.2011.08.066","article-title":"Longitudinal loss of gray matter volume in patients with first-episode schizophrenia: DARTEL automated analysis and ROI validation","volume":"59","author":"Asami","year":"2012","journal-title":"Neuroimage."},{"key":"2025031503121059400_CIT0039","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1176\/appi.ajp.2015.14091108","article-title":"Brain structural abnormalities in a group of never-medicated patients with long-term schizophrenia","volume":"172","author":"Zhang","year":"2015","journal-title":"Am J Psychiatry."},{"key":"2025031503121059400_CIT0040","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/s41386-020-0687-y","article-title":"Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders","volume":"45","author":"Zhang","year":"2020","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0041","doi-asserted-by":"crossref","first-page":"17275","DOI":"10.1038\/srep17275","article-title":"Resting-state cerebellar-cerebral networks are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings","volume":"5","author":"Guo","year":"2015","journal-title":"Sci Rep."},{"key":"2025031503121059400_CIT0042","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/schbul\/sbv062","article-title":"Increased cerebellar functional connectivity with the default-mode network in unaffected siblings of schizophrenia patients at rest","volume":"41","author":"Guo","year":"2015","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0043","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/schbul\/sbab112","article-title":"Cerebello-Thalamo-Cortical hyperconnectivity classifies patients and predicts long-term treatment outcome in first-episode schizophrenia","volume":"48","author":"Cao","year":"2022","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0044","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/schbul\/sbac121","article-title":"Cerebellar functional dysconnectivity in drug-na\u00efve patients with first-episode schizophrenia","volume":"49","author":"Cao","year":"2023","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0045","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1038\/s41467-018-06350-7","article-title":"Cerebello-thalamo-cortical hyperconnectivity as a state-independent functional neural signature for psychosis prediction and characterization","volume":"9","author":"Cao","year":"2018","journal-title":"Nat Commun."},{"key":"2025031503121059400_CIT0046","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0022-3956(97)00038-1","article-title":"Superior temporal gyrus and the course of early schizophrenia: progressive, static, or reversible","volume":"32","author":"Keshavan","year":"1998","journal-title":"J Psychiatr Res."},{"key":"2025031503121059400_CIT0047","doi-asserted-by":"crossref","first-page":"114393","DOI":"10.1016\/j.psychres.2022.114393","article-title":"Low-frequency rTMS treatment alters the topographical organization of functional brain networks in schizophrenia patients with auditory verbal hallucination","volume":"309","author":"Xie","year":"2022","journal-title":"Psychiatry Res."},{"key":"2025031503121059400_CIT0048","doi-asserted-by":"crossref","first-page":"722894","DOI":"10.3389\/fnins.2021.722894","article-title":"rTMS induces brain functional and structural alternations in schizophrenia patient with auditory verbal hallucination","volume":"15","author":"Xie","year":"2021","journal-title":"Front Neurosci."},{"key":"2025031503121059400_CIT0049","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archgenpsychiatry.2010.84","article-title":"Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by \u201cresting state\u201d functional magnetic resonance imaging","volume":"67","author":"Lui","year":"2010","journal-title":"Arch Gen Psychiatry."},{"key":"2025031503121059400_CIT0050","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1001\/archgenpsychiatry.2010.199","article-title":"Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia","volume":"68","author":"Ho","year":"2011","journal-title":"Arch Gen Psychiatry."},{"key":"2025031503121059400_CIT0051","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1176\/appi.ajp.2013.12050674","article-title":"Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study","volume":"170","author":"Andreasen","year":"2013","journal-title":"Am J Psychiatry."},{"key":"2025031503121059400_CIT0052","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/archpsyc.62.4.361","article-title":"Antipsychotic drug effects on brain morphology in first-episode psychosis","volume":"62","author":"Lieberman","year":"2005","journal-title":"Arch Gen Psychiatry."},{"key":"2025031503121059400_CIT0053","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1017\/S0033291709992297","article-title":"A systematic review of the effects of antipsychotic drugs on brain volume","volume":"40","author":"Moncrieff","year":"2010","journal-title":"Psychol Med."},{"key":"2025031503121059400_CIT0054","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1017\/S0033291709005315","article-title":"Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings","volume":"39","author":"Navari","year":"2009","journal-title":"Psychol Med."},{"key":"2025031503121059400_CIT0055","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.npp.1301233","article-title":"Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys","volume":"32","author":"Konopaske","year":"2007","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0056","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.biopsych.2007.08.018","article-title":"Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys","volume":"63","author":"Konopaske","year":"2008","journal-title":"Biol Psychiatry."},{"key":"2025031503121059400_CIT0057","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.neubiorev.2013.06.001","article-title":"Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies","volume":"37","author":"Fusar-Poli","year":"2013","journal-title":"Neurosci Biobehav Rev."},{"key":"2025031503121059400_CIT0058","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/schbul\/sbs118","article-title":"Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjects","volume":"39","author":"Haijma","year":"2013","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0059","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1017\/S003329171000200X","article-title":"Global and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive features","volume":"41","author":"Crespo-Facorro","year":"2011","journal-title":"Psychol Med."},{"key":"2025031503121059400_CIT0060","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1741-7015-11-126","article-title":"Toward the future of psychiatric diagnosis: the seven pillars of RDoC","volume":"11","author":"Cuthbert","year":"2013","journal-title":"BMC Med."},{"key":"2025031503121059400_CIT0061","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/jamapsychiatry.2015.2868","article-title":"Why we need a transdiagnostic staging approach to emerging psychopathology, early diagnosis, and treatment","volume":"73","author":"McGorry","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"2025031503121059400_CIT0062","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41582-023-00904-0","article-title":"Schizophrenia: from neurochemistry to circuits, symptoms and treatments","volume":"20","author":"Howes","year":"2024","journal-title":"Nat Rev Neurol."},{"key":"2025031503121059400_CIT0063","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jamapsychiatry.2019.3360","article-title":"Schizophrenia\u2014an overview","volume":"77","author":"McCutcheon","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"2025031503121059400_CIT0064","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41386-018-0175-9","article-title":"A transdiagnostic neuroanatomical signature of psychiatric illness","volume":"44","author":"Gong","year":"2019","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0065","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/jamapsychiatry.2018.4126","article-title":"Association of a schizophrenia-risk nonsynonymous variant with putamen volume in adolescents: a voxelwise and genome-wide association study","volume":"76","author":"Luo","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"2025031503121059400_CIT0066","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/schbul\/sbac094","article-title":"Effects of antipsychotic medications and illness duration on brain features that distinguish schizophrenia patients","volume":"48","author":"Zeng","year":"2022","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0067","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41593-020-00726-z","article-title":"Challenges and future directions for representations of functional brain organization","volume":"23","author":"Bijsterbosch","year":"2020","journal-title":"Nat Neurosci."},{"key":"2025031503121059400_CIT0068","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1148\/radiol.2015151334","article-title":"Longitudinal changes in resting-state cerebral activity in patients with first-episode schizophrenia: a 1-year follow-up functional MR imaging study","volume":"279","author":"Li","year":"2016","journal-title":"Radiology."},{"key":"2025031503121059400_CIT0069","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1523\/JNEUROSCI.2310-14.2015","article-title":"Early-course unmedicated schizophrenia patients exhibit elevated prefrontal connectivity associated with longitudinal change","volume":"35","author":"Anticevic","year":"2015","journal-title":"J Neurosci."},{"key":"2025031503121059400_CIT0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tics.2017.11.002","article-title":"Large-scale gradients in human cortical organization","volume":"22","author":"Huntenburg","year":"2018","journal-title":"Trends Cogn Sci."},{"key":"2025031503121059400_CIT0071","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41386-022-01512-0","article-title":"Disrupted subcortical functional connectome gradient in drug-na\u00efve first-episode schizophrenia and the normalization effects after antipsychotic treatment","volume":"48","author":"Yang","year":"2023","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0072","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41537-023-00371-y","article-title":"Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response","volume":"9","author":"Yang","year":"2023","journal-title":"Schizophrenia (Heidelb)"},{"key":"2025031503121059400_CIT0073","first-page":"605","article-title":"Altered cerebellar effective connectivity in first-episode schizophrenia and long-term changes after treatment","volume":"78","author":"Wei","year":"2024","journal-title":"Psychiatry Clin Neurosci."},{"key":"2025031503121059400_CIT0074","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/schbul\/sbab082","article-title":"Antipsychotics effects on network-level reconfiguration of cortical morphometry in first-episode schizophrenia","volume":"48","author":"Jiang","year":"2022","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0075","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3389\/fpsyt.2019.00741","article-title":"Reduced brain activity in the right putamen as an early predictor for treatment response in drug-naive, first-episode schizophrenia","volume":"10","author":"Wu","year":"2019","journal-title":"Front Psychiatry."},{"key":"2025031503121059400_CIT0076","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.schres.2020.01.001","article-title":"Effects of risperidone monotherapy on the default-mode network in antipsychotic-na\u00efve first-episode schizophrenia: posteromedial cortex heterogeneity and relationship with the symptom improvements","volume":"218","author":"Duan","year":"2020","journal-title":"Schizophr Res."},{"key":"2025031503121059400_CIT0077","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/schbul\/sbz087","article-title":"Effect of risperidone monotherapy on dynamic functional connectivity of insular subdivisions in treatment-naive, first-episode schizophrenia","volume":"46","author":"Duan","year":"2020","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0078","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/schbul\/sby175","article-title":"A dissociation in effects of risperidone monotherapy on functional and anatomical connectivity within the default mode network","volume":"45","author":"Zong","year":"2019","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0079","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1017\/S0033291716001380","article-title":"Risperidone-induced topological alterations of anatomical brain network in first-episode drug-naive schizophrenia patients: a longitudinal diffusion tensor imaging study","volume":"46","author":"Hu","year":"2016","journal-title":"Psychol Med."},{"key":"2025031503121059400_CIT0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0447.2008.01308.x","article-title":"Definitions of response and remission in schizophrenia: recommendations for their use and their presentation","volume":"438","author":"Leucht","year":"2009","journal-title":"Acta Psychiatr Scand Suppl."},{"key":"2025031503121059400_CIT0081","doi-asserted-by":"crossref","first-page":"e01211","DOI":"10.1002\/brb3.1211","article-title":"Prediction of early response to overall treatment for schizophrenia: a functional magnetic resonance imaging study","volume":"9","author":"Cui","year":"2019","journal-title":"Brain Behav."},{"key":"2025031503121059400_CIT0082","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00406-017-0851-5","article-title":"Neural substrate of unrelenting negative symptoms in schizophrenia: a longitudinal resting-state fMRI study","volume":"268","author":"Li","year":"2018","journal-title":"Eur Arch Psychiatry Clin Neurosci."},{"key":"2025031503121059400_CIT0083","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.schres.2011.03.026","article-title":"Prefrontal lobe dysfunction predicts treatment response in medication-naive first-episode schizophrenia","volume":"129","author":"van Veelen","year":"2011","journal-title":"Schizophr Res."},{"key":"2025031503121059400_CIT0084","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ebiom.2019.07.022","article-title":"Enhanced baseline activity in the left ventromedial putamen predicts individual treatment response in drug-naive, first-episode schizophrenia: results from two independent study samples","volume":"46","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"key":"2025031503121059400_CIT0085","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41386-022-01508-w","article-title":"Anterior cingulate glutamate metabolites as a predictor of antipsychotic response in first-episode psychosis: data from the STRATA collaboration","volume":"48","author":"Egerton","year":"2023","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0086","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41386-023-01741-x","article-title":"Glutamatergic basis of antipsychotic response in first-episode psychosis: a dual voxel study of the anterior cingulate cortex","volume":"49","author":"Fan","year":"2024","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0087","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1038\/npp.2012.113","article-title":"Anterior cingulate glutamate levels related to clinical status following treatment in first-episode schizophrenia","volume":"37","author":"Egerton","year":"2012","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0088","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jpsychires.2019.06.009","article-title":"Gray matter volume changes following antipsychotic therapy in first-episode schizophrenia patients: a longitudinal voxel-based morphometric study","volume":"116","author":"Guo","year":"2019","journal-title":"J Psychiatr Res."},{"key":"2025031503121059400_CIT0089","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/schbul\/sbq126","article-title":"Magnetic resonance imaging predictors of treatment response in first-episode schizophrenia","volume":"38","author":"Szeszko","year":"2012","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0090","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s11682-020-00393-5","article-title":"Less reduced gray matter volume in the subregions of superior temporal gyrus predicts better treatment efficacy in drug-naive, first-episode schizophrenia","volume":"15","author":"Cui","year":"2021","journal-title":"Brain Imaging Behav."},{"key":"2025031503121059400_CIT0091","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s13311-021-01174-8","article-title":"Association between hippocampal subfields and clinical symptoms of first-episode and drug-naive schizophrenia patients during 12 weeks of risperidone treatment","volume":"19","author":"Lang","year":"2022","journal-title":"Neurotherapeutics."},{"key":"2025031503121059400_CIT0092","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41398-023-02714-w","article-title":"Baseline symptom-related white matter tracts predict individualized treatment response to 12-week antipsychotic monotherapies in first-episode schizophrenia","volume":"14","author":"Chen","year":"2024","journal-title":"Transl Psychiatry."},{"key":"2025031503121059400_CIT0093","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.schres.2020.12.011","article-title":"Pretreatment abnormalities in white matter integrity predict one-year clinical outcome in first-episode schizophrenia","volume":"228","author":"Zeng","year":"2021","journal-title":"Schizophr Res."},{"key":"2025031503121059400_CIT0094","doi-asserted-by":"crossref","first-page":"136309","DOI":"10.1016\/j.neulet.2021.136309","article-title":"White matter correlates of impulsivity in frontal lobe and their associations with treatment response in first-episode schizophrenia","volume":"767","author":"Jung","year":"2022","journal-title":"Neurosci Lett."},{"key":"2025031503121059400_CIT0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/brain\/awt310","article-title":"White matter integrity as a predictor of response to treatment in first-episode psychosis","volume":"137","author":"Reis Marques","year":"2014","journal-title":"Brain."},{"key":"2025031503121059400_CIT0096","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biopsych.2019.09.004","article-title":"Neuroimaging heterogeneity in psychosis: neurobiological underpinnings and opportunities for prognostic and therapeutic innovation","volume":"88","author":"Voineskos","year":"2020","journal-title":"Biol Psychiatry."},{"key":"2025031503121059400_CIT0097","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1001\/jamapsychiatry.2015.0505","article-title":"Two patterns of white matter abnormalities in medication-naive patients with first-episode schizophrenia revealed by diffusion tensor imaging and cluster analysis","volume":"72","author":"Sun","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"2025031503121059400_CIT0098","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/schbul\/sbab110","article-title":"Subtyping schizophrenia patients based on patterns of structural brain alterations","volume":"48","author":"Xiao","year":"2022","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0099","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/HRP.0000000000000321","article-title":"Inflammation subtypes and translating inflammation-related genetic findings in schizophrenia and related psychoses: a perspective on pathways for treatment stratification and novel therapies","volume":"30","author":"Bishop","year":"2022","journal-title":"Harv Rev Psychiatry."},{"key":"2025031503121059400_CIT0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.bbi.2023.11.006","article-title":"Free water alterations in different inflammatory subgroups in schizophrenia","volume":"115","author":"Wu","year":"2024","journal-title":"Brain Behav Immun."},{"key":"2025031503121059400_CIT0101","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1038\/s41380-021-01308-6","article-title":"Subtypes of schizophrenia identified by multi-omic measures associated with dysregulated immune function","volume":"26","author":"Luo","year":"2021","journal-title":"Mol Psychiatry."},{"key":"2025031503121059400_CIT0102","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1038\/s41386-022-01300-w","article-title":"A subtype of institutionalized patients with schizophrenia characterized by pronounced subcortical and cognitive deficits","volume":"47","author":"Zhao","year":"2022","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0103","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jpsychires.2018.09.010","article-title":"Leveraging genome-wide association and clinical data in revealing schizophrenia subgroups","volume":"106","author":"Yin","year":"2018","journal-title":"J Psychiatr Res."},{"key":"2025031503121059400_CIT0104","first-page":"433","article-title":"Beyond lumping and splitting: a review of computational approaches for stratifying psychiatric disorders","volume":"1","author":"Marquand","year":"2016","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging."},{"key":"2025031503121059400_CIT0105","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1038\/s41386-018-0120-y","article-title":"Discrete patterns of cortical thickness in youth with bipolar disorder differentially predict treatment response to quetiapine but not lithium","volume":"43","author":"Zhang","year":"2018","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0106","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/sj.mp.4001857","article-title":"Subtyping schizophrenia: implications for genetic research","volume":"11","author":"Jablensky","year":"2006","journal-title":"Mol Psychiatry."},{"key":"2025031503121059400_CIT0107","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1126\/science.1242072","article-title":"Machine learning. Clustering by fast search and find of density peaks","volume":"344","author":"Rodriguez","year":"2014","journal-title":"Science."},{"key":"2025031503121059400_CIT0108","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/s41386-020-00926-y","article-title":"Aberrant triple-network connectivity patterns discriminate biotypes of first-episode medication-naive schizophrenia in two large independent cohorts","volume":"46","author":"Liang","year":"2021","journal-title":"Neuropsychopharmacology."},{"key":"2025031503121059400_CIT0109","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/brain\/awaa025","article-title":"Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning","volume":"143","author":"Chand","year":"2020","journal-title":"Brain."},{"key":"2025031503121059400_CIT0110","first-page":"900","article-title":"Distinct patterns of cerebral cortical thinning in schizophrenia: a neuroimaging data-driven approach","volume":"43","author":"Sugihara","year":"2017","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0111","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/schbul\/sby008","article-title":"Brain subtyping enhances the neuroanatomical discrimination of schizophrenia","volume":"44","author":"Dwyer","year":"2018","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0112","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nature11713","article-title":"Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons","volume":"493","author":"Chaudhury","year":"2013","journal-title":"Nature."},{"key":"2025031503121059400_CIT0113","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature09820","article-title":"Amygdala circuitry mediating reversible and bidirectional control of anxiety","volume":"471","author":"Tye","year":"2011","journal-title":"Nature."},{"key":"2025031503121059400_CIT0114","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell."},{"key":"2025031503121059400_CIT0115","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1038\/s41380-021-01229-4","article-title":"Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis","volume":"26","author":"Liu","year":"2021","journal-title":"Mol Psychiatry."},{"key":"2025031503121059400_CIT0116","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s44220-023-00024-0","article-title":"Neuroimaging biomarkers define neurophysiological subtypes with distinct trajectories in schizophrenia","volume":"1","author":"Jiang","year":"2023","journal-title":"Nature Mental Health"},{"key":"2025031503121059400_CIT0117","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bbi.2020.08.028","article-title":"Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders\u2014a comprehensive systematic review and meta-analysis","volume":"90","author":"Jeppesen","year":"2020","journal-title":"Brain Behav Immun."},{"key":"2025031503121059400_CIT0118","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1017\/S0033291719001995","article-title":"An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis","volume":"49","author":"\u00c7akici","year":"2019","journal-title":"Psychol Med."},{"key":"2025031503121059400_CIT0119","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41586-020-2314-9","article-title":"Variability in the analysis of a single neuroimaging dataset by many teams","volume":"582","author":"Botvinik-Nezer","year":"2020","journal-title":"Nature."},{"key":"2025031503121059400_CIT0120","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41586-022-04492-9","article-title":"Reproducible brain-wide association studies require thousands of individuals","volume":"603","author":"Marek","year":"2022","journal-title":"Nature."},{"key":"2025031503121059400_CIT0121","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/wps.21159","article-title":"Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions","volume":"23","author":"Voineskos","year":"2024","journal-title":"World Psychiatry"},{"key":"2025031503121059400_CIT0122","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/da.23294","article-title":"White matter alterations associated with lifetime and current depression in adolescents: evidence for cingulum disruptions","volume":"39","author":"Barch","year":"2022","journal-title":"Depress Anxiety."},{"key":"2025031503121059400_CIT0123","doi-asserted-by":"crossref","DOI":"10.1101\/2024.01.15.574667","article-title":"Automating the human connectome project\u2019s temporal ICA pipeline","author":"Yang","year":"2024"},{"key":"2025031503121059400_CIT0124","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1176\/appi.ajp.2019.19030225","article-title":"The relationship between White matter microstructure and general cognitive ability in patients with schizophrenia and healthy participants in the ENIGMA Consortium","volume":"177","author":"Holleran","year":"2020","journal-title":"Am J Psychiatry."},{"key":"2025031503121059400_CIT0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/schbul\/sbac043","article-title":"Hippocampal subfield volumes predict disengagement from maintenance treatment in first-episode schizophrenia","volume":"49","author":"Qi","year":"2023","journal-title":"Schizophr Bull."},{"key":"2025031503121059400_CIT0126","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.schres.2019.01.028","article-title":"Citalopram in first-episode schizophrenia: the DECIFER trial","volume":"208","author":"Goff","year":"2019","journal-title":"Schizophr Res."}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/51\/2\/379\/61561128\/sbaf002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/51\/2\/379\/61561128\/sbaf002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T03:12:56Z","timestamp":1742008376000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article\/51\/2\/379\/7972647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":126,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1,22]]},"published-print":{"date-parts":[[2025,3,14]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbaf002","relation":{},"ISSN":["0586-7614","1745-1701"],"issn-type":[{"value":"0586-7614","type":"print"},{"value":"1745-1701","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2025,1,22]]}}}