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We hypothesized that genetic and environmental risk factors that led to SSD act throughout the body and demonstrated the association between lower integrity of peripheral vascular endothelium and white matter (WM) microstructure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Microvascular endothelial function was evaluated using brachial artery post-occlusive reactive hyperemia (PORH), in which endothelial responses are measured under reduced blood flow and after blood flow is restored. White matter microstructure was assessed by multi-shell diffusion tensor imaging in n\u2005=\u200548 healthy controls (HCs) and n\u2005=\u200546 SSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Patients showed significantly lower PORH (F1,90\u2005=\u20055.31, P\u2005=\u2005.02) effect and lower whole-brain fractional anisotropy (FA) values by diffusion imaging (F1,84\u2005=\u20057.46, P\u2005=\u2005.008) with a group\u2005\u00d7\u2005post-occlusion time interaction effect (F3,90\u2005=\u20054.58, P\u2005=\u2005.02). The PORH and whole-brain FA were significantly correlated in the full sample (r\u2005=\u20050.28, P\u2005=\u2005.01) and in SSD (r\u2005=\u20050.4, P\u2005=\u2005.008) separately, but not HC (r\u2005=\u20050.18, P\u2005=\u2005.28).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated, for the first time, significantly lower integrity of vascular endothelium in participants with SSD and showed that it is associated with WM microstructural abnormalities. Together, these findings support the need for a more holistic, body-brain approach to study the pathophysiology of SSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf020","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T15:27:53Z","timestamp":1738337273000},"page":"1658-1667","source":"Crossref","is-referenced-by-count":2,"title":["Peripheral Microvascular and Cerebral White Matter Dysfunction in Schizophrenia: Implications of a Body-Brain Endothelial Pathophysiology"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9676-9230","authenticated-orcid":false,"given":"Eric L","family":"Goldwaser","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine, Department of Psychiatry , New York, NY\u00a010065 ,\u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Yuen","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine , Baltimore, MD\u00a021228 ,\u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyatt","family":"Marshall","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine , Baltimore, MD\u00a021228 ,\u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhim M","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center , Houston, TX\u00a077054 ,\u00a0","place":["United 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