{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:54:34Z","timestamp":1791618874657,"version":"4.3.4"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"STI2030-Major Projects","award":["2021ZD0200800"],"award-info":[{"award-number":["2021ZD0200800"]}]},{"name":"National Key Research and Development Programme","award":["2016YFC0906402"],"award-info":[{"award-number":["2016YFC0906402"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Motivational deficits are core negative symptoms of schizophrenia (SCZ), which have been linked to disruptions in reward network. Recent evidence suggests the cerebellum\u2019s role in motivational and hedonic processing. This study examined its connectivity with the reward network in SCZ and hypothesized that decreased connectivity would be found in SCZ patients and correlated with severe negative symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This study employed a cross-sample validation approach using 2 independent cohorts (Sample 1: NSCZ\u2005=\u200562, NHC\u2005=\u200561; Sample 2: NSCZ\u2005=\u200553, NHC\u2005=\u200555). Resting-state functional connectivity was assessed using network-based analysis to identify disrupted subnetworks, followed by seed-based connectivity analysis to localize specific connections. Effective connectivity was assessed using spectral Dynamic Causal Modeling (DCM) for inferring the directional influences of abnormal connectivity related to amotivation or anhedonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Network-based analysis in Sample 1 identified a disrupted subnetwork between the cerebellum (lobules VI, VIIb, VIII) and basal ganglia (putamen, caudate, pallidum) in SCZ, with cerebellar\u2013pallidal connectivity associated with amotivation. Seed-based analysis in Sample 2 revealed reduced putamen\/caudate-lobule VI connectivity, correlating with amotivation and anhedonia symptoms in SCZ. Spectral DCM indicated reduced excitatory input from cerebellum to the basal ganglia in Sample 1, but such results could not be replicated in Sample 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlighted the role of cerebellum\u2013basal ganglia connectivity in the pathophysiology of SCZ, particularly in relation to amotivation and anhedonia. This pathway may be a putative target for neuromodulation to ameliorate negative symptoms of SCZ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf087","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:21:45Z","timestamp":1746778905000},"source":"Crossref","is-referenced-by-count":7,"title":["Cerebellar\u2013Basal Ganglia Dysconnectivity in Schizophrenia: Insights into Motivational Deficits"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3242-5843","authenticated-orcid":false,"given":"Xuan","family":"Wang","sequence":"first","affiliation":[{"name":"Neuropsychology and Applied Cognitive Neuroscience Laboratory, State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences , Beijing ,","place":["China"]},{"name":"Department of Psychology, University of Chinese Academy of Sciences , Beijing 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