{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T11:00:41Z","timestamp":1774090841486,"version":"3.50.1"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["JP18K15509"],"award-info":[{"award-number":["JP18K15509"]}]},{"name":"JSPS KAKENHI","award":["JP22K15745"],"award-info":[{"award-number":["JP22K15745"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Excessive saturated or deficient unsaturated fatty acids and white matter microstructural abnormalities are observed before the psychosis onset. Whereas fatty acids variations are implicated in white matter pathology, conventional Diffusion Tensor Imaging has limitations in disentangling their biological relevance. Free-water imaging provides improved biological specificity to white matter microstructure, such as fractional volume of free-water (FW) and tissue-specific fractional anisotropy (FAt). This study aims to investigate the associations between altered proportion of saturated or unsaturated fatty acids and free-water imaging parameters in prodromal psychosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We applied free-water imaging and Tract-Based Spatial Statistics to compare FAt and FW between 78 individuals with at-risk mental state (ARMS) and 129 healthy controls. In a subsample with available blood samples (n\u2005=\u200553 and n\u2005=\u200542, respectively), relationships between fatty acid composition of erythrocyte membrane and FAt or FW were examined alongside clinical and cognitive variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Compared to the controls, individuals with ARMS exhibited higher relative concentrations of saturated fatty acids as well as lower FAt and higher FW in multiple association and projection fibers. In the ARMS group, elevated proportion of saturated fatty acids was associated with lower FAt and with positive symptoms and impaired verbal fluency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The association of saturated fatty acids with FAt in ARMS suggests that fatty acids may influence disrupted white matter microstructure, such as impaired myelin maintenance prior to psychosis onset. Future studies should explore early interventions to mitigate white matter cellular deterioration by optimizing saturated fatty acid levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf089","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:50:31Z","timestamp":1747036231000},"source":"Crossref","is-referenced-by-count":0,"title":["Saturated Fatty Acids and White Matter Microstructure in Individuals With At-risk Mental State"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8512-7438","authenticated-orcid":false,"given":"Daiki","family":"Sasabayashi","sequence":"first","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]},{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]},{"name":"Research Center for Idling Brain Science, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]},{"name":"Research Center for Idling Brain Science, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-9829","authenticated-orcid":false,"given":"Kiyotaka","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Medicine, University of Tsukuba , Tsukuba ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-4813","authenticated-orcid":false,"given":"Yuko","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]},{"name":"Research Center for Idling Brain Science, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Akasaki","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]},{"name":"Department of Child Mental Health and Development, Toyama University Hospital , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana","family":"Wickham","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Ik K","family":"Cho","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]},{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]},{"name":"Department of Radiology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheshan","family":"Mohandass","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Zurrin","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tashrif","family":"Billah","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suheyla","family":"Cetin-Karayumak","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]},{"name":"Research Center for Idling Brain Science, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Takayanagi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]},{"name":"Arisawabashi Hospital , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Tsujii","sequence":"additional","affiliation":[{"name":"Department of Child Mental Health and Development, Toyama University Hospital , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Koike","sequence":"additional","affiliation":[{"name":"The University of Tokyo Institute for Diversity and Adaptation of Human Mind , Tokyo ,","place":["Japan"]},{"name":"Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo , Tokyo ,","place":["Japan"]},{"name":"International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-9677","authenticated-orcid":false,"given":"Yoji","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Division of Clinical Neuroscience, University of Miyazaki , Miyazaki ,","place":["Japan"]},{"name":"Institute of Industrial Science, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyo","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomiki","family":"Sumiyoshi","sequence":"additional","affiliation":[{"name":"Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry , Tokyo ,","place":["Japan"]},{"name":"Department of Psychiatry, National Center of Neurology and Psychiatry Hospital , Tokyo ,","place":["Japan"]},{"name":"Japan Health Research Promotion Bureau , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]},{"name":"Research Center for Idling Brain Science, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences , Toyama ,","place":["Japan"]},{"name":"Research Center for Idling Brain Science, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Kubicki","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]},{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]},{"name":"Department of Radiology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"2026032106215018000_CIT0001","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0920-9964(94)90043-4","article-title":"The membrane hypothesis of schizophrenia","volume":"13","author":"Horrobin","year":"1994","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0002","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.plefa.2003.08.008","article-title":"From membrane phospholipid defects to altered neurotransmission: is arachidonic acid a nexus in the pathophysiology of schizophrenia","volume":"69","author":"Skosnik","year":"2003","journal-title":"Prostaglandins Leukot Essent Fatty Acids."},{"key":"2026032106215018000_CIT0003","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0920-9964(97)00151-5","article-title":"The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia","volume":"30","author":"Horrobin","year":"1998","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0004","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.3390\/ijms23052577","article-title":"Fatty acids: an insight into the pathogenesis of neurodegenerative diseases and therapeutic potential","volume":"23","author":"Vesga-Jim\u00e9nez","year":"2022","journal-title":"Int J Mol Sci ."},{"key":"2026032106215018000_CIT0005","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.plefa.2010.07.001","article-title":"Polyunsaturated fatty acids deficits are associated with psychotic state and negative symptoms in patients with schizophrenia","volume":"83","author":"Sethom","year":"2010","journal-title":"Prostaglandins Leukot Essent Fatty Acids."},{"key":"2026032106215018000_CIT0006","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.schres.2012.08.014","article-title":"A meta-analysis of the polyunsaturated fatty acid composition of erythrocyte membranes in schizophrenia","volume":"141","author":"van der Kemp","year":"2012","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psychres.2012.09.041","article-title":"Red blood cell polyunsaturated fatty acids measured in red blood cells and schizophrenia: a meta-analysis","volume":"207","author":"Hoen","year":"2013","journal-title":"Psychiatry Res."},{"key":"2026032106215018000_CIT0008","doi-asserted-by":"crossref","first-page":"827","DOI":"10.5498\/wjp.v12.i6.827","article-title":"Disrupted leptin-fatty acid biosynthesis is an early manifestation of metabolic abnormalities in schizophrenia","volume":"12","author":"Khan","year":"2022","journal-title":"World J Psychiatry"},{"key":"2026032106215018000_CIT0009","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2011.1472","article-title":"Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk","volume":"69","author":"Fusar-Poli","year":"2012","journal-title":"Arch Gen Psychiatry."},{"key":"2026032106215018000_CIT0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.psychres.2015.04.036","article-title":"Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls","volume":"228","author":"Rice","year":"2015","journal-title":"Psychiatry Res."},{"key":"2026032106215018000_CIT0011","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.schres.2019.06.020","article-title":"Comparison of erythrocyte omega-3 index, fatty acids and molecular phospholipid species in people at ultra-high risk of developing psychosis and healthy people","volume":"226","author":"Alqarni","year":"2020","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0012","doi-asserted-by":"crossref","first-page":"1188452","DOI":"10.3389\/fpsyt.2023.1188452","article-title":"Analysis of polyunsaturated fatty acids in antipsychotic-free individuals with at-risk mental state and patients with first-episode schizophrenia","volume":"14","author":"Le","year":"2023","journal-title":"Front Psychiatry."},{"key":"2026032106215018000_CIT0013","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-2275(20)39619-X","article-title":"Lipid composition of the normal human brain: gray matter, white matter, and myelin","volume":"6","author":"O\u2019Brien","year":"1965","journal-title":"J Lipid Res."},{"key":"2026032106215018000_CIT0014","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s11011-009-9160-7","article-title":"Changes in erythrocyte membrane fatty acids during a clinical trial of eicosapentaenoic acid (EPA) supplementation in schizophrenia","volume":"24","author":"van Rensburg","year":"2009","journal-title":"Metab Brain Dis."},{"key":"2026032106215018000_CIT0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.plefa.2017.05.001","article-title":"Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: an update on neuroimaging findings","volume":"136","author":"McNamara","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids."},{"key":"2026032106215018000_CIT0016","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1093\/cercor\/bht163","article-title":"Long-chain omega-3 fatty acids improve brain function and structure in older adults","volume":"24","author":"Witte","year":"2014","journal-title":"Cereb Cortex."},{"key":"2026032106215018000_CIT0017","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1194\/jlr.D029546","article-title":"Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways","volume":"53","author":"Huang","year":"2012","journal-title":"J Lipid Res."},{"key":"2026032106215018000_CIT0018","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jneuroim.2014.11.007","article-title":"Omega-3 polyunsaturated fatty acids ameliorate neuroinflammation and mitigate ischemic stroke damage through interactions with astrocytes and microglia","volume":"278","author":"Zendedel","year":"2015","journal-title":"J Neuroimmunol."},{"key":"2026032106215018000_CIT0019","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1007\/s12035-015-9554-y","article-title":"Enriched endogenous omega-3 polyunsaturated fatty acids protect cortical neurons from experimental ischemic injury","volume":"53","author":"Shi","year":"2016","journal-title":"Mol Neurobiol."},{"key":"2026032106215018000_CIT0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuint.2017.09.008","article-title":"Palmitic acid stimulates energy metabolism and inhibits insulin\/PI3K\/AKT signaling in differentiated human neuroblastoma cells: the role of mTOR activation and mitochondrial ROS production","volume":"110","author":"Calvo-Ochoa","year":"2017","journal-title":"Neurochem Int."},{"key":"2026032106215018000_CIT0021","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1038\/s41380-019-0509-y","article-title":"White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study","volume":"25","author":"Cetin-Karayumak","year":"2020","journal-title":"Mol Psychiatry."},{"key":"2026032106215018000_CIT0022","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-030-35206-6_4","article-title":"White matter pathology in schizophrenia","volume-title":"Neuroimaging in Schizophrenia","author":"Di Biase","year":"2020"},{"key":"2026032106215018000_CIT0023","doi-asserted-by":"crossref","first-page":"325789","DOI":"10.1155\/2011\/325789","article-title":"Ultrastructural alterations of myelinated fibers and oligodendrocytes in the prefrontal cortex in schizophrenia: a postmortem morphometric study","volume":"2011","author":"Uranova","year":"2011","journal-title":"Schizophr Res Treatment"},{"key":"2026032106215018000_CIT0024","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fncel.2014.00005","article-title":"Susceptibility genes and oligodendroglial and myelin related abnormalities","volume":"8","author":"Roussos","year":"2014","journal-title":"Front Cell Neurosci."},{"key":"2026032106215018000_CIT0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpsychires.2005.05.005","article-title":"A review of diffusion tensor imaging studies in schizophrenia","volume":"41","author":"Kubicki","year":"2007","journal-title":"J Psychiatr Res."},{"key":"2026032106215018000_CIT0026","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.schres.2008.11.021","article-title":"Meta-analysis of diffusion tensor imaging studies in schizophrenia","volume":"108","author":"Ellison-Wright","year":"2009","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0027","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/mp.2017.170","article-title":"Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group","volume":"23","author":"Kelly","year":"2018","journal-title":"Mol Psychiatry."},{"key":"2026032106215018000_CIT0028","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.3390\/jcm10112515","article-title":"Disturbances in white matter integrity in the ultra-high-risk psychosis state-a systematic review","volume":"10","author":"Waszczuk","year":"2021","journal-title":"J Clin Med"},{"key":"2026032106215018000_CIT0029","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.plefa.2009.04.007","article-title":"Polyunsaturated fatty acids and brain white matter anisotropy in recent-onset schizophrenia: a preliminary study","volume":"81","author":"Peters","year":"2009","journal-title":"Prostaglandins Leukot Essent Fatty Acids."},{"key":"2026032106215018000_CIT0030","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/schbul\/sbs089","article-title":"Polyunsaturated fatty acid concentration predicts myelin integrity in early-phase psychosis","volume":"39","author":"Peters","year":"2013","journal-title":"Schizophr Bull."},{"key":"2026032106215018000_CIT0031","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1001\/archgenpsychiatry.2010.199","article-title":"Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia","volume":"68","author":"Ho","year":"2011","journal-title":"Arch Gen Psychiatry."},{"key":"2026032106215018000_CIT0032","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3389\/fncel.2014.00384","article-title":"Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes","volume":"8","author":"Steiner","year":"2014","journal-title":"Front Cell Neurosci."},{"key":"2026032106215018000_CIT0033","doi-asserted-by":"crossref","first-page":"e100703","DOI":"10.1136\/gpsych-2021-100703","article-title":"Different patterns of association between white matter microstructure and plasma unsaturated fatty acids in those with high risk for psychosis and healthy participants","volume":"35","author":"Su","year":"2022","journal-title":"Gen Psychiatr"},{"key":"2026032106215018000_CIT0034","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neuroimage.2018.04.051","article-title":"Advances in microstructural diffusion neuroimaging for psychiatric disorders","volume":"182","author":"Pasternak","year":"2018","journal-title":"Neuroimage."},{"key":"2026032106215018000_CIT0035","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/mrm.22055","article-title":"Free water elimination and mapping from diffusion MRI","volume":"62","author":"Pasternak","year":"2009","journal-title":"Magn Reson Med."},{"key":"2026032106215018000_CIT0036","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.neuroimage.2011.08.043","article-title":"How and how not to correct for CSF-contamination in diffusion MRI","volume":"59","author":"Metzler-Baddeley","year":"2012","journal-title":"Neuroimage."},{"key":"2026032106215018000_CIT0037","doi-asserted-by":"crossref","first-page":"17365","DOI":"10.1523\/JNEUROSCI.2904-12.2012","article-title":"Excessive extracellular volume reveals a neurodegenerative pattern in schizophrenia onset","volume":"32","author":"Pasternak","year":"2012","journal-title":"J Neurosci."},{"key":"2026032106215018000_CIT0038","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/mp.2017.43","article-title":"Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning","volume":"23","author":"Lyall","year":"2018","journal-title":"Mol Psychiatry."},{"key":"2026032106215018000_CIT0039","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1038\/s41380-023-02068-1","article-title":"Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization","volume":"28","author":"Cetin-Karayumak","year":"2023","journal-title":"Mol Psychiatry."},{"key":"2026032106215018000_CIT0040","doi-asserted-by":"crossref","first-page":"111219","DOI":"10.1016\/j.pscychresns.2020.111219","article-title":"A 16-week randomized placebo-controlled trial investigating the effects of omega-3 polyunsaturated fatty acid treatment on white matter microstructure in recent-onset psychosis patients concurrently treated with risperidone","volume":"307","author":"Lyall","year":"2021","journal-title":"Psychiatry Res Neuroimaging"},{"key":"2026032106215018000_CIT0041","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1017\/S0033291716001410","article-title":"Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study","volume":"46","author":"Wang","year":"2016","journal-title":"Psychol Med."},{"key":"2026032106215018000_CIT0042","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1176\/appi.ajp.2019.18091044","article-title":"Altered Cellular White Matter But Not Extracellular Free Water on Diffusion MRI in Individuals at Clinical High Risk for Psychosis","volume":"176","author":"Tang","year":"2019","journal-title":"Am J Psychiatry."},{"key":"2026032106215018000_CIT0043","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/15622975.2020.1775890","article-title":"Cellular and extracellular white matter alterations indicate conversion to psychosis among individuals at clinical high-risk for psychosis","volume":"22","author":"N\u00e4gele","year":"2021","journal-title":"World J Biol Psychiatry."},{"key":"2026032106215018000_CIT0044","doi-asserted-by":"crossref","first-page":"6833","DOI":"10.1038\/s41380-021-01128-8","article-title":"White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis","volume":"26","author":"Di Biase","year":"2021","journal-title":"Mol Psychiatry."},{"key":"2026032106215018000_CIT0045","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.schres.2024.04.012","article-title":"Nomenclature for psychosis risk in Japan: Survey results from high-risk individuals, caregivers, and mental health professionals","volume":"267","author":"Takahashi","year":"2024","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0046","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0006-3223(02)01549-4","article-title":"Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder","volume":"53","author":"Hibbeln","year":"2003","journal-title":"Biol Psychiatry."},{"key":"2026032106215018000_CIT0047","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1751-7893.2008.00104.x","article-title":"Clinical practice and research activities for early psychiatric intervention at Japanese leading centres","volume":"3","author":"Mizuno","year":"2009","journal-title":"Early Interv Psychiatry"},{"key":"2026032106215018000_CIT0048","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1080\/j.1440-1614.2005.01714.x","article-title":"Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States","volume":"39","author":"Yung","year":"2005","journal-title":"Aust N Z J Psychiatry."},{"key":"2026032106215018000_CIT0049","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1751-7893.2009.00118.x","article-title":"Application of the Comprehensive Assessment of At-Risk Mental States (CAARMS) to the Japanese population: reliability and validity of the Japanese version of the CAARMS","volume":"3","author":"Miyakoshi","year":"2009","journal-title":"Early Interv Psychiatry."},{"key":"2026032106215018000_CIT0050","doi-asserted-by":"crossref","first-page":"s120","DOI":"10.1192\/bjp.187.48.s120","article-title":"International clinical practice guidelines for early psychosis","volume":"48","author":"International Early Psychosis Association Writing Group","year":"2005","journal-title":"British J Psychiatry Suppl"},{"key":"2026032106215018000_CIT0051","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders","author":"First","year":"1997"},{"key":"2026032106215018000_CIT0052","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull."},{"key":"2026032106215018000_CIT0053","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.schres.2003.09.011","article-title":"The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery","volume":"68","author":"Keefe","year":"2004","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0054","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1440-1819.2007.01725.x","article-title":"Brief assessment of cognition in schizophrenia: validation of the Japanese version","volume":"61","author":"Kaneda","year":"2007","journal-title":"Psychiatry Clin Neurosci."},{"key":"2026032106215018000_CIT0055","first-page":"259","article-title":"Schizophrenia Cognition Rating Scale Japanese version (SCoRS-J) as a co-primary measure assessing cognitive function in schizophrenia","volume":"31","author":"Kaneda","year":"2011","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi."},{"key":"2026032106215018000_CIT0056","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0033-3182(95)71666-8","article-title":"Global assessment of functioning. A modified scale","volume":"36","author":"Hall","year":"1995","journal-title":"Psychosomatics."},{"key":"2026032106215018000_CIT0057","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1176\/ajp.149.9.1148","article-title":"Revising axis V for DSM-IV: a review of measures of social functioning","volume":"149","author":"Goldman","year":"1992","journal-title":"Am J Psychiatry."},{"key":"2026032106215018000_CIT0058","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-1781(03)00220-8","article-title":"Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients","volume":"121","author":"Ranjekar","year":"2003","journal-title":"Psychiatry Res."},{"key":"2026032106215018000_CIT0059","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.psychres.2010.07.049","article-title":"Membrane fatty acid levels as a predictor of treatment response in chronic schizophrenia","volume":"186","author":"Sumiyoshi","year":"2011","journal-title":"Psychiatry Res."},{"key":"2026032106215018000_CIT0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.psychres.2006.05.025","article-title":"Essential polyunsaturated fatty acids and social cognition in schizophrenia","volume":"157","author":"Sumiyoshi","year":"2008","journal-title":"Psychiatry Res."},{"key":"2026032106215018000_CIT0061","doi-asserted-by":"crossref","first-page":"1361997","DOI":"10.3389\/fpsyt.2024.1361997","article-title":"Relationships between erythrocyte membrane mono- and poly-unsaturated fatty acid composition and clinical\/cognitive indices in antipsychotic-free schizophrenia patients","volume":"15","author":"Higuchi","year":"2024","journal-title":"Front Psychiatry."},{"key":"2026032106215018000_CIT0062","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage."},{"key":"2026032106215018000_CIT0063","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuroimage.2018.11.042","article-title":"QuickNAT. A fully convolutional network for quick and accurate segmentation of neuroanatomy","volume":"186","author":"Guha","year":"2019","journal-title":"Neuroimage."},{"key":"2026032106215018000_CIT0064","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41597-024-03058-w","article-title":"Harmonized diffusion MRI data and white matter measures from the Adolescent Brain Cognitive Development Study","volume":"11","author":"Cetin-Karayumak","year":"2024","journal-title":"Sci Data."},{"key":"2026032106215018000_CIT0065","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/hbm.21192","article-title":"Head injury or head motion? Assessment and quantification of motion artifacts in diffusion tensor imaging studies","volume":"33","author":"Ling","year":"2012","journal-title":"Hum Brain Mapp."},{"key":"2026032106215018000_CIT0066","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D Slicer as an image computing platform for the Quantitative Imaging Network","volume":"30","author":"Fedorov","year":"2012","journal-title":"Magn Reson Imaging."},{"key":"2026032106215018000_CIT0067","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage."},{"key":"2026032106215018000_CIT0068","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"Neuroimage."},{"key":"2026032106215018000_CIT0069","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage."},{"key":"2026032106215018000_CIT0070","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1093\/schbul\/sbac011","article-title":"Impaired membrane lipid homeostasis in schizophrenia","volume":"48","author":"Li","year":"2022","journal-title":"Schizophr Bull."},{"key":"2026032106215018000_CIT0071","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbadis.2016.01.019","article-title":"Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system","volume":"1862","author":"Yoon","year":"2016","journal-title":"Biochim Biophys Acta."},{"key":"2026032106215018000_CIT0072","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neurobiolaging.2019.03.018","article-title":"Exercise prevents obesity-induced cognitive decline and white matter damage in mice","volume":"80","author":"Graham","year":"2019","journal-title":"Neurobiol Aging."},{"key":"2026032106215018000_CIT0073","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1471-4159.2009.05886.x","article-title":"Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders","volume":"108","author":"Whitney","year":"2009","journal-title":"J Neurochem."},{"key":"2026032106215018000_CIT0074","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0920-9964(94)90014-0","article-title":"Red blood cell membrane dynamics in schizophrenia. I. Membrane fluidity","volume":"11","author":"Yao","year":"1994","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0075","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ana.23593","article-title":"Dietary fat types and 4-year cognitive change in community-dwelling older women","volume":"72","author":"Okereke","year":"2012","journal-title":"Ann Neurol."},{"key":"2026032106215018000_CIT0076","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41430-024-01468-y","article-title":"Association of the serum levels of saturated fatty acids and mild cognitive impairment: a cross-sectional study","volume":"78","author":"Li","year":"2024","journal-title":"Eur J Clin Nutr."},{"key":"2026032106215018000_CIT0077","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1017\/S1368980007000080","article-title":"n-3 fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study","volume":"11","author":"Beydoun","year":"2008","journal-title":"Public Health Nutr."},{"key":"2026032106215018000_CIT0078","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3390\/nu15061499","article-title":"Supplementation with flaxseed oil rich in alpha-linolenic acid improves verbal fluency in healthy older adults","volume":"15","author":"Ogawa","year":"2023","journal-title":"Nutrients"},{"key":"2026032106215018000_CIT0079","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/pcn.13599","article-title":"Increased proportions of circulating pro-inflammatory monocytes and macrophages expressing toll-like receptor 4 in individuals with schizophrenia and bipolar disorder receiving medication","volume":"77","author":"Tsai","year":"2023","journal-title":"Psychiatry Clin Neurosci."},{"key":"2026032106215018000_CIT0080","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/pcn.13670","article-title":"Association between serum cytokines and timeframe for conversion from clinical high-risk to psychosis","volume":"78","author":"Zhang","year":"2024","journal-title":"Psychiatry Clin Neurosci."},{"key":"2026032106215018000_CIT0081","doi-asserted-by":"crossref","first-page":"264","DOI":"10.5498\/wjp.v12.i2.264","article-title":"Insights into myelin dysfunction in schizophrenia and bipolar disorder","volume":"12","author":"Vald\u00e9s-Tovar","year":"2022","journal-title":"World J Psychiatry"},{"key":"2026032106215018000_CIT0082","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.schres.2014.07.031","article-title":"The extent of diffusion MRI markers of neuroinflammation and white matter deterioration in chronic schizophrenia","volume":"161","author":"Pasternak","year":"2015","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0083","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.schres.2017.02.006","article-title":"Characterizing white matter changes in chronic schizophrenia: a free-water imaging multi-site study","volume":"189","author":"Oestreich","year":"2017","journal-title":"Schizophr Res."},{"key":"2026032106215018000_CIT0084","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41586-022-04554-y","article-title":"Brain charts for the human lifespan","volume":"604","author":"Bethlehem","year":"2022","journal-title":"Nature."},{"key":"2026032106215018000_CIT0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1503\/jpn.150030","article-title":"Frontal fasciculi and psychotic symptoms in antipsychotic-naive patients with schizophrenia before and after 6 weeks of selective dopamine D2\/3 receptor blockade","volume":"41","author":"Ebdrup","year":"2016","journal-title":"J Psychiatry Neurosci."},{"key":"2026032106215018000_CIT0086","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1176\/appi.ajp.2018.17121402","article-title":"White matter abnormalities in never-treated patients with long-term schizophrenia","volume":"175","author":"Xiao","year":"2018","journal-title":"Am J Psychiatry."},{"key":"2026032106215018000_CIT0087","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1038\/s41380-024-02597-3","article-title":"Excessive interstitial free-water in cortical gray matter preceding accelerated volume changes in individuals at clinical high risk for psychosis","volume":"29","author":"Cho","year":"2024","journal-title":"Mol Psychiatry."},{"key":"2026032106215018000_CIT0088","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3390\/medicina59091514","article-title":"Fatty acid composition of a maternal diet and erythrocyte phospholipid status in Latvian pregnant women","volume":"59","author":"Nikolajeva","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"2026032106215018000_CIT0089","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2188\/jea.JE20081007","article-title":"Review of food frequency questionnaires developed and validated in Japan","volume":"19","author":"Wakai","year":"2009","journal-title":"J Epidemiol."},{"key":"2026032106215018000_CIT0090","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neuroimage.2018.08.073","article-title":"Retrospective harmonization of multi-site diffusion MRI data acquired with different acquisition parameters","volume":"184","author":"Cetin Karayumak","year":"2019","journal-title":"Neuroimage."}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/52\/2\/sbaf089\/63574356\/sbaf089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/52\/2\/sbaf089\/63574356\/sbaf089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T10:22:12Z","timestamp":1774088532000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article\/doi\/10.1093\/schbul\/sbaf089\/8173278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":90,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,25]]},"published-print":{"date-parts":[[2026,3,7]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbaf089","relation":{},"ISSN":["0586-7614","1745-1701"],"issn-type":[{"value":"0586-7614","type":"print"},{"value":"1745-1701","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,6,25]]},"article-number":"sbaf089"}}