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Eighteen percent of past participants converted to psychosis, half in the original studies and the remainder since last evaluated. Of those who converted to psychosis, the majority met criteria for an affective psychosis, consistent with the high rate of affective disorders (70%) in the non-converted group. An additional 7% of past participants died, substantially higher than the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These early data highlight the potential of how this dataset, when combined with baseline data, can be used to answer new questions about the life course of high-risk youth and how we might intervene early to improve their long-term outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf133","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T13:14:03Z","timestamp":1752585243000},"source":"Crossref","is-referenced-by-count":5,"title":["Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-4605","authenticated-orcid":false,"given":"Kristin S","family":"Cadenhead","sequence":"first","affiliation":[{"name":"Department of Psychiatry, UCSD , San Diego, CA 92093-0810 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, UCSD , San Diego, CA 92093-0810 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heline","family":"Mirzakhanian","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, UCSD , San Diego, CA 92093-0810 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Addington","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary , Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-923X","authenticated-orcid":false,"given":"Carrie E","family":"Bearden","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, UCLA , Los Angeles, CA 90095 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyrone D","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Psychology, Yale University , New Haven, CT 06511 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo E","family":"Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , Hempstead, NY 11549 ,","place":["United 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