{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:29:03Z","timestamp":1786703343120,"version":"build-2736575974"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Talent and Fundamental Research Project of Yunnan Province","award":["202301AY070001-299"],"award-info":[{"award-number":["202301AY070001-299"]}]},{"name":"Talent and Fundamental Research Project of Yunnan Province","award":["202105\u00a0AC160004"],"award-info":[{"award-number":["202105\u00a0AC160004"]}]},{"name":"Talent and Fundamental Research Project of Yunnan Province","award":["202301AT070037"],"award-info":[{"award-number":["202301AT070037"]}]},{"name":"Special Project for Social Development of Yunnan Province","award":["202203\u00a0AC100007"],"award-info":[{"award-number":["202203\u00a0AC100007"]}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","award":["RF1028623032"],"award-info":[{"award-number":["RF1028623032"]}],"id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2102205"],"award-info":[{"award-number":["U2102205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460289"],"award-info":[{"award-number":["82460289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Metabolic dysregulation has been widely observed in psychiatric disorders. However, the causal relationships between metabolites and psychiatric disorders remain largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Here, we conducted bidirectional Mendelian randomization (MR) analyses to systematically investigate causal relationships between 8 psychiatric disorders (including attention deficit hyperactivity disorder (ADHD), anorexia nervosa (AN), anxiety, bipolar disorder (BIP), depression, posttraumatic stress disorder (PTSD), insomnia, and schizophrenia (SCZ)) and 1139 blood metabolites (including 823 metabolite levels and 316 metabolite ratios).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>In forward MR, we identified 34, 21, 56, and 1 metabolites that are associated with BIP, SCZ, depression, and PTSD, respectively. Notably, several metabolites are associated with the risk of multiple psychiatric disorders. For instance, N2,N2-dimethylguanosine, 1,2-dipalmitoyl-gpc (16:0\/16:0), and phosphatidylcholine acyl-alkyl C38:4 were negatively associated with the risk of SCZ and BIP. In reverse MR analyses, we explored the causal effects of psychiatric disorders on metabolites, and found that blood metabolites are also influenced by psychiatric disorders. For example, depression significantly affected 21 metabolite levels, including positively associated with 21-hydroxypregnenolone disulfate, and negatively associated with carotenoid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings not only uncover the causal relationships between metabolites and psychiatric disorders, but also provide potential therapeutic targets for the prevention and treatment of these psychiatric disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf154","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T11:41:20Z","timestamp":1754739680000},"source":"Crossref","is-referenced-by-count":0,"title":["Mendelian-Randomization Study Reveals Causal Relationships Between Blood Metabolites and Psychiatric Disorders"],"prefix":"10.1093","volume":"52","author":[{"given":"Changgai","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Advanced Institute for Life and Health, Southeast University , Nanjing, Jiangsu 210096 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglun","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Advanced Institute for Life and Health, Southeast University , Nanjing, Jiangsu 210096 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Advanced Institute for Life and Health, Southeast University , Nanjing, Jiangsu 210096 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong-Jian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Advanced Institute for Life and Health, Southeast University , Nanjing, Jiangsu 210096 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Teng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, Yunnan Provincial Department of Education Gut Microbiota Transplantation Engineering Research Center, The Second Affiliated Hospital of Kunming Medical University , Kunming, Yunnan 650106 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