{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T22:55:51Z","timestamp":1774133751574,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019787","name":"Sophia","doi-asserted-by":"publisher","award":["WAR22-68"],"award-info":[{"award-number":["WAR22-68"]}],"id":[{"id":"10.13039\/100019787","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon Europe Research and Innovation Program","award":["101057529"],"award-info":[{"award-number":["101057529"]}]},{"name":"Netherlands Organization for Scientific Research","award":["015.016.056"],"award-info":[{"award-number":["015.016.056"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program","award":["101057390"],"award-info":[{"award-number":["101057390"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program","award":["953327"],"award-info":[{"award-number":["953327"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children of parents with psychotic disorders have a \u02c350% increased risk to develop mental health problems, and over 30% have developed severe mental illness by early adulthood. Aberrant brain development may underly this familial risk. We aimed to investigate differences in brain development, reflected in fetal head circumference (HC) growth trajectories and HC at birth, between children of women with psychotic disorders and population-based controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We collected fetal ultrasonography assessments at 20, 30, and 36\u00a0weeks of gestational age (GA) from medical records of N\u2009=\u2009140 pregnant women having a psychotic disorder diagnosis and their N\u2009=\u2009168 children. In the Generation R study, ultrasonography assessments were performed in the first, second, and\/or third trimester in N\u2009=\u20098605 pregnant women and their children. In both groups, HC at birth was measured with measuring tape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Using generalized additive mixed modeling, we observed decreased non-linear fetal HC growth for offspring of women with psychotic disorders vs. controls from 30.7\u00a0weeks GA onwards. At birth, no significant difference was observed (b\u2009=\u20090.22, 95% CI [\u20130.133 to 0.573]), although offspring exposed to maternal psychosis showed more obstetric complications and suboptimal birth outcomes, including lower birthweight (b\u2009=\u2009\u2013136.1, 95% CI [\u2013229.0 to \u201343.2]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study showed decreased fetal head growth during the third trimester and lower birthweight in children of women with psychotic disorders. Together, these findings highlight potential relevance of altered fetal head growth for later neurodevelopmental outcomes and provide directions for possible underlying mechanisms of risk transmission in psychosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf171","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:41:24Z","timestamp":1756899684000},"source":"Crossref","is-referenced-by-count":1,"title":["Fetal Head Growth and Head Circumference at Birth in Children of Women with Psychotic Disorders and Population-Based Controls"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-093X","authenticated-orcid":false,"given":"Lisanne A E M","family":"van Houtum","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology, Erasmus MC, University Medical Centre Rotterdam \u2013 Sophia , 3015 CN Rotterdam ,","place":["The 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Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre Rotterdam \u2013 Sophia , 3015 GD Rotterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-5015","authenticated-orcid":false,"given":"Hanan","family":"El Marroun","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology, Erasmus MC, University Medical Centre Rotterdam \u2013 Sophia , 3015 CN Rotterdam ,","place":["The Netherlands"]},{"name":"Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Sciences, Erasmus University Rotterdam , 3063 ND Rotterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeltje E M","family":"van Haren","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology, Erasmus MC, University Medical Centre Rotterdam 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