{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:52:04Z","timestamp":1791435124669,"version":"4.3.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UKRI Future Leaders Fellowship"},{"name":"British Medical Association Margaret Temple Award for Schizophrenia Research","id":[{"id":"https:\/\/ror.org\/02caz1f24","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Astor foundation","award":["MR\/S003436\/1"],"award-info":[{"award-number":["MR\/S003436\/1"]}],"id":[{"id":"https:\/\/ror.org\/002qz3r93","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015250","name":"NIHR Bristol Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203315"],"award-info":[{"award-number":["NIHR203315"]}],"id":[{"id":"10.13039\/100015250","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Medical Research Council and Wellcome","award":["217065\/Z\/19\/Z"],"award-info":[{"award-number":["217065\/Z\/19\/Z"]}],"id":[{"id":"https:\/\/ror.org\/03x94j517","id-type":"ROR","asserted-by":"crossref"}]},{"name":"ALSPAC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Despite growing evidence of a causal association between developmental trauma (DT) and psychotic experiences (PEs), the precise neurobiological mechanisms underlying this association remain poorly understood. We examined the effect of DT on the structure of brain regions involved in threat and memory processing, and the role of these alterations in the association between DT and PEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This study used data from the Avon Longitudinal Study of Parents and Children, a large, population-based birth cohort in the United Kingdom. Data were available from 419 participants, including DT reported by the parents or the participants between ages 0 and 17\u00a0years, PEs at age 18, and volumes of regions involved in threat and memory processing in adulthood (mean\u2009=\u200921,2, SD\u2009=\u20091.5\u00a0years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>DT exposure was associated with increased odds of PEs (odds ratio [OR]\u2009=\u20091.64; 95% CI, 1.04-2.59, P\u00a0=\u2009.035), with evidence supporting cumulative risk effects for exposure to multiple trauma types (B\u00a0=\u00a00.160, P\u00a0&amp;lt;\u2009.001). DT was also associated with reduced left amygdala volumes (B\u00a0=\u2009\u22120.011, P\u00a0=\u2009.02) with evidence again supporting cumulative risk effect with multiple trauma types (B\u00a0=\u2009\u22120.006, P\u00a0=\u2009.01). Reduced bilateral amygdala volume was associated with an increased odds of PEs driven by the left amygdala (OR\u2009=\u00a00.001, 95% CI, 0.000-0.154, P\u00a0=\u2009.006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings are consistent with theories that alterations in brain regions involved in threat and memory processing lie on the neurobiological pathway from DT to PEs, offering the possibility of prevention strategies for psychosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf184","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T11:44:05Z","timestamp":1759232645000},"source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Developmental Trauma on Brain Structures Involved in Threat and Memory Processing and Its Relation to Psychotic Experiences in Adulthood"],"prefix":"10.1093","volume":"52","author":[{"given":"Ava J C","family":"Mason","sequence":"first","affiliation":[{"name":"Division of Psychiatry, UCL Institute of Mental Health, University College London , London W1T 7NF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G Y","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, UCL Institute of Mental Health, University College London , London W1T 7NF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Merritt","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, UCL Institute of Mental Health, University College London , London W1T 7NF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences (FANS), Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , Denmark Hill, SE5 8AB ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Zammit","sequence":"additional","affiliation":[{"name":"Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, School of Medicine , UHW Main Building, Heath Park, Cardiff, CF14 4XN ,","place":["United Kingdom"]},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol , Bristol, BS8 2PS ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek K","family":"Jones","sequence":"additional","affiliation":[{"name":"Brain Research Imaging Centre (CUBRIC), Cardiff University , Cardiff, CF24 4HQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S","family":"David","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, 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