{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:06:30Z","timestamp":1790143590588,"version":"4.0.1"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Psychotic and traumatic-stress symptoms commonly co-occur. Psychological interventions have increasingly targeted these co-occurring symptoms. However, information on their efficacy, tolerability, and acceptability is limited in this evolving field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>After preregistration at PROSPERO (CRD42024553934), we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of psychological interventions with persons aged 16+ reporting both psychotic and traumatic-stress symptoms. PubMed, CINAHL, Embase, PsycINFO, Clinicaltrials.gov, and Web of Science were searched in July 2024. We used the Revised Cochrane Risk-of-Bias Tool for Randomized Trials (RoB-2) for bias assessment. Random-effects models were used to synthesize clinical outcomes, while meta-regression was applied when 10 effect sizes were reported per outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>We included 10 RCTs with 559 participants. Interventions primarily targeted trauma-related symptoms and were seemingly tolerable and acceptable, with low adverse event profiles and a dropout rate of 14%. In comparison to usual treatments and active control treatments, interventions significantly decreased traumatic-stress symptoms at post-treatment (g\u2009=\u00a00.33, 95% CI [0.08, 0.57]), with meta-regression favoring interventions primarily employing exposure (gdiff\u00a0=\u00a00.59, [0.22, 0.97]). Interventions significantly decreased traumatic-stress symptoms at follow-up (g\u2009=\u00a00.34, [0.12, 0.56]), but not total psychotic, positive, or negative symptoms at either timeframe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings suggest that psychological interventions for co-occurring psychotic and traumatic-stress symptoms are safe, tolerable, and may reduce traumatic-stress symptoms when employing exposure. Considering the substantial risk of bias, the small number of trials, non-significant results for other clinical and functional outcomes, and unexplained heterogeneity, further research is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf185","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:58:35Z","timestamp":1758801515000},"source":"Crossref","is-referenced-by-count":5,"title":["Psychological Interventions for Persons With Co-occurring Psychotic and Traumatic-Stress Symptoms: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7616-1885","authenticated-orcid":false,"given":"Helen","family":"Niemeyer","sequence":"first","affiliation":[{"name":"Department of Clinical Psychological Intervention, Freie Universit\u00e4t Berlin , Berlin 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,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-3112","authenticated-orcid":false,"given":"Emily A","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University , Uppsala, Uppsala County ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-4936","authenticated-orcid":false,"given":"Kerem","family":"B\u00f6ge","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Psychiatry, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin (corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin) , Campus Charite Mitte, Berlin ,","place":["Germany"]},{"name":"Department of Clinical Psychology and Psychotherapy, Medical University Brandenburg-Theodor Fontane , Neuruppin ,","place":["Germany"]},{"name":"German Center of 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