{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:51:36Z","timestamp":1791435096576,"version":"4.3.3"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"AMP SCZ","award":["U24MH124629"],"award-info":[{"award-number":["U24MH124629"]}]},{"name":"AMP SCZ","award":["U01MH124631"],"award-info":[{"award-number":["U01MH124631"]}]},{"name":"AMP SCZ","award":["U01MH124639"],"award-info":[{"award-number":["U01MH124639"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220664\/Z\/20\/Z"],"award-info":[{"award-number":["220664\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220664\/A\/20\/Z"],"award-info":[{"award-number":["220664\/A\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NHMRC CRE PREEMPT","award":["1198304"],"award-info":[{"award-number":["1198304"]}]},{"name":"NARSAD Frederick & Alice Coles and Thomas & Nancy Coles Young Investigator Award","award":["32738"],"award-info":[{"award-number":["32738"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypotheses<\/jats:title>\n                    <jats:p>Functional impairment often precedes attenuated psychotic symptoms (APS) in youth at clinical high risk (CHR) for psychosis. This impairment has been linked to baseline symptoms and cognition, but the roles of developmental stage of APS onset and comorbid depression\/anxiety are not well understood. Accelerating Medicines Partnership\u2014Schizophrenia\u2019s diverse international sample and broad symptom assessment facilitate a detailed analysis of premorbid functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Premorbid adjustment and baseline symptoms and cognition were examined in 1056 individuals at CHR (n\u2009=\u2009482 early-symptom, n\u2009=\u2009574 late-symptom [first CHR-level APS in childhood\/early adolescence vs. late adolescence\/adulthood]). In the late-symptom group, growth curve models tested adjustment trends from childhood through late adolescence. Incremental relationships between adjustment, symptoms, and cognition were tested controlling for depression\/anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Premorbid social maladjustment correlated with baseline negative symptoms (r\u2009\u2265\u2009.25, P\u00a0&amp;lt;\u2009.001). Premorbid academic maladjustment correlated with baseline negative symptoms (r\u2009\u2265\u2009.17, P\u00a0\u2264\u2009.007) and cognitive impairment (r\u2009\u2265\u2009.27, P\u00a0\u2264\u2009.001). Effects did not differ between early- and late-symptom subgroups (\u0394r\u2009\u2264\u2009.12, z\u2009\u2264\u20092.00, P\u00a0&amp;gt;\u2009.05). Social adjustment deteriorated over time in participants with more baseline negative symptoms (\u03b3\u2009=\u20090.14, P\u00a0&amp;lt;\u2009.001) or cognitive impairment (\u03b3\u2009\u2265\u2009\u22120.01, P\u00a0&amp;lt;\u2009.004), even when controlling for depression\/anxiety. APS were generally unrelated to premorbid functioning. Effects were consistent in the subsample residing outside North America (n\u2009=\u2009579).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Relationships between premorbid adjustment, negative symptoms, and cognition were independent of depression\/anxiety and developmental stage of CHR symptom onset. Baseline negative symptoms and cognitive impairment follow insidious and worsening functional problems originating in early clinical stages, prior to onset of APS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf197","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:50:41Z","timestamp":1760442641000},"source":"Crossref","is-referenced-by-count":2,"title":["Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership\u2014Schizophrenia"],"prefix":"10.1093","volume":"52","author":[{"given":"Henry R","family":"Cowan","sequence":"first","affiliation":[{"name":"Department of Psychology, Michigan State University , East Lansing, MI 44824 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-4317","authenticated-orcid":false,"given":"Danielle","family":"Pratt","sequence":"additional","affiliation":[{"name":"Department of Psychology, Northwestern University , Evanston, IL 60208 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-6990","authenticated-orcid":false,"given":"Jai L","family":"Shah","sequence":"additional","affiliation":[{"name":"Douglas Research Centre , Montreal H4H 1R3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W","family":"Woods","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neuroscience, Yale University School of Medicine , New Haven, CT 06511 ,","place":["United 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Montreal H4H 1R3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart A","family":"Shankman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Northwestern University , Chicago, IL 60611 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Addington","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary , Calgary, AB T2N 4Z6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso","family":"Arango","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense , Madrid 28007 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National Psychosis Unit, South London and Maudsley NHS Foundation Trust , London WC2R 2LS ,","place":["United Kingdom"]},{"name":"Service of General Psychiatry, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital (CHUV) , Lausanne 1011 ,","place":["Switzerland"]},{"name":"Department of Psychiatry, Instituto de Investigaci\u00f3n Sanitaria de Sevilla, IBiS, Hospital Universitario Virgen del Roc\u00edo, Universidad de Sevilla , Sevilla 41013 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl M","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A","family":"Cornblatt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , 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