{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:08:39Z","timestamp":1792786119175,"version":"4.5.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIHR Oxford Health Biomedical Research Centre"},{"name":"#NEXTGENERATIONEU","award":["DN. 1553 11.10.2022"],"award-info":[{"award-number":["DN. 1553 11.10.2022"]}]},{"name":"Wellcome Trust Early Career Award","award":["WT\/304693_Z_23"],"award-info":[{"award-number":["WT\/304693_Z_23"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"UK Medical Research Council and King\u2019s College London member of the MRC Doctoral Training Partnership in Biomedical Sciences","award":["MR\/W006820\/1"],"award-info":[{"award-number":["MR\/W006820\/1"]}],"id":[{"id":"https:\/\/ror.org\/0220mzb33","id-type":"ROR","asserted-by":"crossref"}]},{"name":"UK Medical Research Council and King\u2019s College London member of the MRC Doctoral Training Partnership in Biomedical Sciences","award":["MR\/N013700\/1"],"award-info":[{"award-number":["MR\/N013700\/1"]}],"id":[{"id":"https:\/\/ror.org\/0220mzb33","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>The majority of first episode psychosis (FEP) patients are undetected (DET\u2212) by clinical high-risk for psychosis (CHR-P) services prior to onset and therefore do not receive preventive care for psychosis. We compared features of the psychosis prodrome (symptoms and substance use) between DET\u2212 and FEP patients detected by CHR-P services (DET+) to determine whether they share a common prodromal phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective Reporting of Studies Conducted Using Observational Routinely Collected Health Data statement-compliant electronic health record cohort study. We extracted 65 prodromal features (symptoms and substance use before FEP onset) using natural language processing to assess the presence, duration, and first presentation of the psychosis prodrome and occurrences of features across the prodrome. Duration and feature occurrences were compared between DET+ and DET\u2212 individuals using Mann-Whitney U tests and Wilcoxon Effect Size, while presence and first presentation were compared using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>A total of 1545 FEP patients (n\u00a0=\u2009119 DET+ [mean age 28.7\u00a0years; SD\u2009=\u20099.4; 61.6% male]) were included. There were no significant differences in the presence (DET\u2009+\u2009=85.0%, DET\u2212\u2009=\u200985.6%, P\u00a0=\u2009.83) or duration (DET\u2009+\u2009=18.8\u00a0months, DET\u2212\u2009=\u200918.4\u00a0months, P\u00a0=\u2009.89) of the psychosis prodrome. There were no significant differences in first presentation of psychotic symptoms between groups (Pcorr\u00a0&amp;gt;\u2009.05). Frequency of occurrences of thought broadcasting (r\u00a0=\u20090.07, Pcorr\u00a0=\u2009.04) was higher and hostility (r\u00a0=\u20090.08, Pcorr\u00a0=\u2009.04) lower in DET+ compared to DET\u2212 across the prodrome, though effect sizes were small.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DET+ and DET\u2212 individuals experience similar psychosis prodromes prior to FEP onset. DET\u2212 individuals can likely be identified earlier if detection strategies are improved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf201","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:07:56Z","timestamp":1763654876000},"source":"Crossref","is-referenced-by-count":5,"title":["Can We Detect the Undetected? Comparing the Prodromes of Individuals with First Episode Psychosis Detected and Undetected by Clinical High-Risk for Psychosis Services: An Electronic Health Record Study"],"prefix":"10.1093","volume":"52","author":[{"given":"Maisie","family":"Inns","sequence":"first","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London , London, SE5 8AF ,","place":["United Kingdom"]},{"name":"Cheshire and Wirral Partnership NHS Foundation Trust , Chester, CH2 1BQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London , London, SE5 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0182-3493","authenticated-orcid":false,"given":"Maite","family":"Arribas","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London , London, SE5 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-8767","authenticated-orcid":false,"given":"Yanakan","family":"Logeswaran","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London , London, SE5 8AF ,","place":["United Kingdom"]},{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London SE5 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6309-6324","authenticated-orcid":false,"given":"Amedeo","family":"Minichino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford, OX3 7JX ,","place":["United Kingdom"]},{"name":"NIHR Oxford Health Biomedical Research Centre , Oxford, OX3 7JX ,","place":["United Kingdom"]},{"name":"OPEN Early Detection Service, Oxford Health NHS Foundation Trust , Oxford, OX3 7JX ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford, OX3 7JX ,","place":["United Kingdom"]},{"name":"NIHR Oxford Health Biomedical Research Centre , Oxford, OX3 7JX ,","place":["United Kingdom"]},{"name":"OPEN Early Detection Service, Oxford Health NHS Foundation Trust , Oxford, OX3 7JX ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-5715","authenticated-orcid":false,"given":"Andrea","family":"De Micheli","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London , London, SE5 8AF ,","place":["United Kingdom"]},{"name":"OASIS Service, South London and Maudsley NHS Foundation Trust , London, SE11 5DL ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-6990","authenticated-orcid":false,"given":"Jai L","family":"Shah","sequence":"additional","affiliation":[{"name":"Prevention and Early Intervention Program for Psychoses (PEPP-Montreal), Douglas Mental Health University Institute , Montr\u00e9al, QC , H4H 1A8,","place":["Canada"]},{"name":"Department of Psychiatry, McGill University , Montr\u00e9al, QC, H3A 1A1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford, OX3 7JX ,","place":["United Kingdom"]},{"name":"NIHR Oxford Health Biomedical Research Centre , Oxford, OX3 7JX ,","place":["United Kingdom"]},{"name":"OPEN Early Detection Service, Oxford Health NHS Foundation Trust , Oxford, OX3 7JX ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-6788","authenticated-orcid":false,"given":"Paolo","family":"Fusar-Poli","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London , London, SE5 8AF ,","place":["United Kingdom"]},{"name":"OASIS Service, South London and Maudsley NHS Foundation Trust , London, SE11 5DL ,","place":["United Kingdom"]},{"name":"Department of Brain and Behavioral Sciences, University of Pavia , Pavia, 27100 ,","place":["Italy"]},{"name":"Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University , Munich, 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-3407","authenticated-orcid":false,"given":"Dominic","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford, OX3 7JX ,","place":["United Kingdom"]},{"name":"NIHR Oxford Health Biomedical Research Centre , Oxford, OX3 7JX ,","place":["United Kingdom"]},{"name":"OPEN Early Detection Service, Oxford Health NHS Foundation Trust , Oxford, OX3 7JX ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"2026100800434966100_ref1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1001\/jamapsychiatry.2019.4779","article-title":"Prevention of psychosis: advances in detection, prognosis, and intervention","volume":"77","author":"Fusar-Poli","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"2026100800434966100_ref2","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1093\/schbul\/sbx166","article-title":"Can we reduce the duration of untreated psychosis? A systematic review and meta-analysis of controlled interventional studies","volume":"44","author":"Oliver","year":"2018","journal-title":"Schizophr Bull"},{"key":"2026100800434966100_ref3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/wps.20514","article-title":"Beyond the \u201cat risk mental state\u201d concept: transitioning to transdiagnostic psychiatry","volume":"17","author":"McGorry","year":"2018","journal-title":"World Psychiatry"},{"key":"2026100800434966100_ref4","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1001\/jamapsychiatry.2017.0284","article-title":"Development and validation of a clinically based risk calculator for the transdiagnostic prediction of psychosis","volume":"74","author":"Fusar-Poli","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"2026100800434966100_ref5","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3389\/fpsyt.2019.00774","article-title":"Improving the detection of individuals at clinical risk for psychosis in the community, primary and secondary care: an integrated evidence-based approach","volume":"10","author":"Fusar-Poli","year":"2019","journal-title":"Front Psychiatry"},{"key":"2026100800434966100_ref6","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/s41380-024-02415-w","article-title":"On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis","volume":"29","author":"Benrimoh","year":"2024","journal-title":"Mol Psychiatry"},{"key":"2026100800434966100_ref7","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1093\/schbul\/sbad152","article-title":"Combinations and temporal associations among precursor symptoms before a first episode of psychosis","volume":"50","author":"Paquin","year":"2024","journal-title":"Schizophr Bull"},{"key":"2026100800434966100_ref8","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1017\/S0033291721003755","article-title":"Dynamic association of the first identifiable symptom with rapidity of progression to first-episode psychosis","volume":"53","author":"Paquin","year":"2023","journal-title":"Psychol Med"},{"key":"2026100800434966100_ref9","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1037\/abn0000806","article-title":"Transsyndromic trajectories from pre-onset self-harm and subthreshold psychosis to the first episode of psychosis: a longitudinal study","volume":"132","author":"Paquin","year":"2023","journal-title":"J Psychopathol Clin Sci"},{"key":"2026100800434966100_ref10","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1176\/appi.ps.201600304","article-title":"Is the clinical high-risk state a valid concept? Retrospective examination in a first-episode psychosis sample","volume":"68","author":"Shah","year":"2017","journal-title":"Psychiatr Serv"},{"key":"2026100800434966100_ref11","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.1038\/s41380-022-01611-w","article-title":"Prognostic accuracy and clinical utility of psychometric instruments for individuals at clinical high-risk of psychosis: a systematic review and meta-analysis","volume":"27","author":"Oliver","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2026100800434966100_ref12","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1038\/s41380-025-02896-3","article-title":"Longitudinal evolution of the transdiagnostic prodrome to severe mental disorders: a dynamic temporal network analysis informed by natural language processing and electronic health records","volume":"30","author":"Arribas","year":"2025","journal-title":"Mol Psychiatry"},{"key":"2026100800434966100_ref13","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1038\/s41380-024-02533-5","article-title":"A transdiagnostic prodrome for severe mental disorders: an electronic health record study","volume":"29","author":"Arribas","year":"2024","journal-title":"Mol Psychiatry"},{"key":"2026100800434966100_ref14","doi-asserted-by":"publisher","first-page":"e012012","DOI":"10.1136\/bmjopen-2016-012012","article-title":"Natural language processing to extract symptoms of severe mental illness from clinical text: the clinical record interactive search comprehensive data extraction (CRIS-CODE) project","volume":"7","author":"Jackson","year":"2017","journal-title":"BMJ Open"},{"key":"2026100800434966100_ref15","author":"National Health Service","year":"2023"},{"key":"2026100800434966100_ref16","doi-asserted-by":"publisher","first-page":"577110","DOI":"10.3389\/fpsyt.2020.577110","article-title":"Early intervention Services for First Episode of psychosis in South London and the Maudsley (SLaM): 20 years of care and research for Young people","volume":"11","author":"Fusar-Poli","year":"2020","journal-title":"Front Psychiatry"},{"key":"2026100800434966100_ref17","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.euroneuro.2020.08.002","article-title":"Outreach and support in South-London (OASIS) 2001\u20142020: twenty years of early detection, prognosis and preventive care for young people at risk of psychosis","volume":"39","author":"Fusar-Poli","year":"2020","journal-title":"Eur Neuropsychopharmacol"},{"key":"2026100800434966100_ref18","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1001\/jamapsychiatry.2016.2707","article-title":"Deconstructing pretest risk enrichment to optimize prediction of psychosis in individuals at clinical high risk","volume":"73","author":"Fusar-Poli","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"2026100800434966100_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.06.015","article-title":"Why transition risk to psychosis is not declining at the OASIS ultra high risk service: the hidden role of stable pretest risk enrichment","volume":"192","author":"Fusar-Poli","year":"2017","journal-title":"Schizophr Res"},{"key":"2026100800434966100_ref20","author":"NICE","year":"2014"},{"key":"2026100800434966100_ref21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jad.2016.05.053","article-title":"Persistence or recurrence of non-psychotic comorbid mental disorders associated with 6-year poor functional outcomes in patients at ultra high risk for psychosis","volume":"203","author":"Rutigliano","year":"2016","journal-title":"J Affect Disord"},{"key":"2026100800434966100_ref22","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.schres.2017.03.043","article-title":"Comorbid diagnoses for youth at clinical high risk of psychosis","volume":"190","author":"Addington","year":"2017","journal-title":"Schizophr Res"},{"key":"2026100800434966100_ref23","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1192\/bjo.2024.782","article-title":"A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders","volume":"11","author":"Di Forti","year":"2025","journal-title":"BJPsych Open"},{"key":"2026100800434966100_ref24","doi-asserted-by":"publisher","first-page":"e008721","DOI":"10.1136\/bmjopen-2015-008721","article-title":"Cohort profile of the South London and Maudsley NHS Foundation Trust biomedical research Centre (SLaM BRC) case register: current status and recent enhancement of an electronic mental health record-derived data resource","volume":"6","author":"Perera","year":"2016","journal-title":"BMJ Open"},{"key":"2026100800434966100_ref25","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/S0140-6736(15)01223-4","article-title":"Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust biomedical research Centre (SLaM BRC) clinical record interactive search (CRIS) register","volume":"387","author":"Roberts","year":"2016","journal-title":"Lancet"},{"key":"2026100800434966100_ref26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1471-244X-9-51","article-title":"The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive data","volume":"9","author":"Stewart","year":"2009","journal-title":"BMC Psychiatry"},{"key":"2026100800434966100_ref27","author":"National Health Service","year":"2023"},{"key":"2026100800434966100_ref28","doi-asserted-by":"crossref","DOI":"10.1002\/9781119870203","volume-title":"The Maudsley Prescribing Guidelines in Psychiatry","author":"Taylor","year":"2021","edition":"1st"},{"key":"2026100800434966100_ref29","volume-title":"Ethnic Group, National Identity and Religion","author":"Office for National Statistics"},{"key":"2026100800434966100_ref30","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1093\/schbul\/sbaa183","article-title":"Timing, distribution, and relationship between nonpsychotic and subthreshold psychotic symptoms prior to emergence of a first episode of psychosis","volume":"47","author":"Cupo","year":"2021","journal-title":"Schizophr Bull"},{"key":"2026100800434966100_ref31","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1017\/S0033291709990651","article-title":"Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11?","volume":"39","author":"Demjaha","year":"2009","journal-title":"Psychol Med"},{"key":"2026100800434966100_ref32","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0920-9964(00)00190-0","article-title":"Integrating psychopathological dimensions in functional psychoses: a hierarchical approach","volume":"52","author":"Cuesta","year":"2001","journal-title":"Schizophr Res"},{"key":"2026100800434966100_ref33","volume-title":"CRIS Natural Language Processing","author":"Maudsley Biomedical Research Centre","year":"2021"},{"key":"2026100800434966100_ref34","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"Shapiro","year":"1965","journal-title":"Biometrika."},{"key":"2026100800434966100_ref35","first-page":"278","volume-title":"Contributions to Probability and Statistics: Essays in Honor of Harold Hotelling","author":"Levene","year":"1960"},{"key":"2026100800434966100_ref36","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988","edition":"2nd"},{"key":"2026100800434966100_ref37","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1214\/aoms\/1177730491","article-title":"On a test of whether one of two random variables is stochastically larger than the other","volume":"18","author":"Mann","year":"1947","journal-title":"Ann Math Stat"},{"key":"2026100800434966100_ref38","first-page":"19","article-title":"The need to report effect size estimates revisited. An overview of some recommended measures of effect size","volume":"1","author":"Tomczak","year":"2014","journal-title":"Trends Sport Sci"},{"key":"2026100800434966100_ref39","doi-asserted-by":"publisher","first-page":"945505","DOI":"10.3389\/fpsyt.2022.945505","article-title":"Mapping the implementation and challenges of clinical services for psychosis prevention in England","volume":"13","author":"Estrad\u00e9","year":"2023","journal-title":"Front Psychiatry."},{"key":"2026100800434966100_ref40","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/eip.12950","article-title":"Worldwide implementation of clinical services for the prevention of psychosis: the IEPA early intervention in mental health survey","volume":"14","author":"Kotlicka-Antczak","year":"2020","journal-title":"Early Interv Psychiatry"},{"key":"2026100800434966100_ref41","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1007\/s00127-021-02090-0","article-title":"First help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care","volume":"56","author":"Ferrara","year":"2021","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"2026100800434966100_ref42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.2975\/30.2006.54.60","article-title":"Understanding help seeking delay in the Prodrome to first episode psychosis: a secondary analysis of the perspectives of Young people","volume":"30","author":"Boydell","year":"2006","journal-title":"Psychiatr Rehabil J"},{"key":"2026100800434966100_ref43","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/j.1751-7893.2007.00041.x","article-title":"Trajectory to a first episode of psychosis: a qualitative research study with families: qualitative family study of first psychosis","volume":"1","author":"Corcoran","year":"2007","journal-title":"Early Interv Psychiatry"},{"key":"2026100800434966100_ref44","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.bbi.2018.11.315","article-title":"Association of baseline inflammatory markers and the development of negative symptoms in individuals at clinical high risk for psychosis","volume":"76","author":"Goldsmith","year":"2019","journal-title":"Brain Behav Immun"},{"key":"2026100800434966100_ref45","doi-asserted-by":"publisher","first-page":"1016154","DOI":"10.3389\/fpsyt.2022.1016154","article-title":"A network analysis of anxiety, depressive, and psychotic symptoms and functioning in children and adolescents at clinical high risk for psychosis","volume":"13","author":"Lo Buglio","year":"2022","journal-title":"Front Psychiatry."},{"key":"2026100800434966100_ref46","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1093\/schbul\/sbz039","article-title":"What causes the onset of psychosis in individuals at clinical high risk? A meta-analysis of risk and protective factors","volume":"46","author":"Oliver","year":"2020","journal-title":"Schizophr Bull"},{"key":"2026100800434966100_ref47","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1017\/S0033291713000251","article-title":"Negative psychotic symptoms and impaired role functioning predict transition outcomes in the at-risk mental state: a latent class cluster analysis study","volume":"43","author":"Valmaggia","year":"2013","journal-title":"Psychol Med"},{"key":"2026100800434966100_ref48","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.schres.2004.12.020","article-title":"Integrated treatment ameliorates negative symptoms in first episode psychosis\u2014results from the Danish OPUS trial","volume":"79","author":"Thorup","year":"2005","journal-title":"Schizophr Res"},{"key":"2026100800434966100_ref49","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/schbul\/sbv161","article-title":"Self-evaluation of negative symptoms: a novel tool to assess negative symptoms","volume":"42","author":"Dollfus","year":"2016","journal-title":"Schizophr Bull"},{"key":"2026100800434966100_ref50","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s00127-006-0117-4","article-title":"Help-seeking pathways in early psychosis","volume":"41","author":"Platz","year":"2006","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"2026100800434966100_ref51","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1751-7893.2009.00154.x","article-title":"A descriptive review of qualitative studies in first episode psychosis","volume":"4","author":"Boydell","year":"2010","journal-title":"Early Interv Psychiatry"},{"key":"2026100800434966100_ref52","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/papt.12531","article-title":"Psychosis and help-seeking behaviour\u2014a systematic review of the literature","volume":"97","author":"Skrobinska","year":"2024","journal-title":"Psychol Psychother Theory Res Pract"},{"key":"2026100800434966100_ref53","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00109","article-title":"Real world implementation of a Transdiagnostic risk calculator for the automatic detection of individuals at risk of psychosis in clinical routine: study protocol","volume":"10","author":"Fusar-Poli","year":"2019","journal-title":"Front Psychiatry"},{"key":"2026100800434966100_ref54","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S2215-0366(15)00491-5","article-title":"Intensive community outreach for those at ultra high risk of psychosis: dilution, not solution","volume":"3","author":"Fusar-Poli","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"2026100800434966100_ref55","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/schbul\/sby069","article-title":"Using online screening in the general population to detect participants at clinical high-risk for psychosis","volume":"45","author":"McDonald","year":"2019","journal-title":"Schizophr Bull"},{"key":"2026100800434966100_ref56","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fpsyt.2019.00174","article-title":"Psychosis polyrisk score (PPS) for the detection of individuals at-risk and the prediction of their outcomes","volume":"10","author":"Oliver","year":"2019","journal-title":"Front Psychiatry."},{"key":"2026100800434966100_ref57","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.schres.2020.04.015","article-title":"Real-world digital implementation of the psychosis polyrisk score (PPS): a pilot feasibility study","volume":"226","author":"Oliver","year":"2020","journal-title":"Schizophr Res"},{"key":"2026100800434966100_ref58","doi-asserted-by":"publisher","first-page":"105699","DOI":"10.1016\/j.neubiorev.2024.105699","article-title":"Exploring causal mechanisms of psychosis risk","volume":"162","author":"Oliver","year":"2024","journal-title":"Neurosci Biobehav Rev"},{"key":"2026100800434966100_ref59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41537-023-00332-5","article-title":"Relapse prediction in schizophrenia with smartphone digital phenotyping during COVID-19: a prospective, three-site, two-country, longitudinal study","volume":"9","author":"Cohen","year":"2023","journal-title":"Schizophrenia"},{"key":"2026100800434966100_ref60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41746-023-00977-7","article-title":"Classifying and clustering mood disorder patients using smartphone data from a feasibility study","volume":"6","author":"Langholm","year":"2023","journal-title":"NPJ Digit Med"},{"key":"2026100800434966100_ref61","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.schres.2022.06.031","article-title":"Developing and internally validating a prognostic model (P risk) to improve the prediction of psychosis in a primary care population using electronic health records: the MAPPED study","volume":"246","author":"Sullivan","year":"2022","journal-title":"Schizophr Res"},{"key":"2026100800434966100_ref62","doi-asserted-by":"publisher","first-page":"e854","DOI":"10.3399\/BJGP.2024.0017","article-title":"External validation of a prognostic model to improve prediction of psychosis in primary care","volume":"74","author":"Sullivan","year":"2024","journal-title":"Br J Gen Pract"},{"key":"2026100800434966100_ref63","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1093\/schbul\/sby070","article-title":"Transdiagnostic risk calculator for the automatic detection of individuals at risk and the prediction of psychosis: second replication in an independent national health service trust","volume":"45","author":"Fusar-Poli","year":"2019","journal-title":"Schizophr Bull"},{"key":"2026100800434966100_ref64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-020-01032-9","article-title":"Transdiagnostic individualized clinically-based risk calculator for the automatic detection of individuals at-risk and the prediction of psychosis: external replication in 2,430,333 US patients","volume":"10","author":"Oliver","year":"2020","journal-title":"Transl Psychiatry"},{"key":"2026100800434966100_ref65","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.schres.2021.01.005","article-title":"Third external replication of an individualised transdiagnostic prediction model for the automatic detection of individuals at risk of psychosis using electronic health records","volume":"228","author":"Puntis","year":"2021","journal-title":"Schizophr Res"},{"key":"2026100800434966100_ref66","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.schres.2020.05.007","article-title":"Real-world implementation of precision psychiatry: Transdiagnostic risk calculator for the automatic detection of individuals at-risk of psychosis","volume":"227","author":"Oliver","year":"2021","journal-title":"Schizophr Res"},{"key":"2026100800434966100_ref67","doi-asserted-by":"publisher","first-page":"e60794","DOI":"10.3791\/60794","article-title":"Implementation of a real-time psychosis risk detection and alerting system based on electronic health records using CogStack","volume":"159","author":"Wang","year":"2020","journal-title":"J Vis Exp"},{"key":"2026100800434966100_ref68","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.biopsych.2024.02.1006","article-title":"Using electronic health records to facilitate precision psychiatry","volume":"96","author":"Oliver","year":"2024","journal-title":"Biol Psychiatry"},{"key":"2026100800434966100_ref69","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/schbul\/sbaa126","article-title":"Using natural language processing on electronic health records to enhance detection and prediction of psychosis risk","volume":"47","author":"Irving","year":"2021","journal-title":"Schizophr Bull"},{"key":"2026100800434966100_ref70","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.biopsych.2024.05.022","article-title":"Dynamic and Transdiagnostic risk calculator based on natural language processing for the prediction of psychosis in secondary mental health care: development and internal-external validation cohort study","volume":"96","author":"Krakowski","year":"2024","journal-title":"Biol Psychiatry"},{"key":"2026100800434966100_ref71","doi-asserted-by":"publisher","first-page":"115745","DOI":"10.1016\/j.psychres.2024.115745","article-title":"Transdiagnostic risk identification: a validation study of the clinical high at risk mental state (CHARMS) criteria","volume":"333","author":"Destr\u00e9e","year":"2024","journal-title":"Psychiatry Res"},{"key":"2026100800434966100_ref72","doi-asserted-by":"publisher","first-page":"S2215036624000609","DOI":"10.1016\/S2215-0366(24)00060-9","article-title":"Staging 2\u00b70: refining transdiagnostic clinical staging frameworks to enhance reliability and utility for youth mental health","volume":"11","author":"Scott","year":"2024","journal-title":"Lancet Psychiatry"},{"key":"2026100800434966100_ref73","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1001\/jamapsychiatry.2019.2003","article-title":"Bringing clinical staging to youth mental health: from concept to operationalization (and Back again)","volume":"76","author":"Shah","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"2026100800434966100_ref74","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/wps.20745","article-title":"Transdiagnostic clinical staging in youth mental health: a first international consensus statement","volume":"19","author":"Shah","year":"2020","journal-title":"World Psychiatry"},{"key":"2026100800434966100_ref75","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S2215-0366(21)00467-3","article-title":"Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis","volume":"9","author":"Shah","year":"2022","journal-title":"Lancet Psychiatry"},{"key":"2026100800434966100_ref76","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1038\/s41380-023-02202-z","article-title":"Towards a youth mental health paradigm: a perspective and roadmap","volume":"28","author":"Uhlhaas","year":"2023","journal-title":"Mol Psychiatry"},{"key":"2026100800434966100_ref77","doi-asserted-by":"publisher","first-page":"105626","DOI":"10.1016\/j.neubiorev.2024.105626","article-title":"The future of preventive psychiatry is precise and transdiagnostic","volume":"160","author":"Oliver","year":"2024","journal-title":"Neurosci Biobehav Rev"},{"key":"2026100800434966100_ref78","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s12888-016-0963-x","article-title":"Can mental health diagnoses in administrative data be used for research? A systematic review of the accuracy of routinely collected diagnoses","volume":"16","author":"Davis","year":"2016","journal-title":"BMC Psychiatry"},{"key":"2026100800434966100_ref79","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1136\/amiajnl-2012-001145","article-title":"Next-generation phenotyping of electronic health records","volume":"20","author":"Hripcsak","year":"2013","journal-title":"J Am Med Inform Assoc"},{"key":"2026100800434966100_ref80","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/acps.13712","article-title":"Digital phenotyping data and anomaly detection methods to assess changes in mood and anxiety symptoms across a transdiagnostic clinical sample","volume":"151","author":"Cohen","year":"2024","journal-title":"Acta Psychiatr Scand"},{"key":"2026100800434966100_ref81","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1192\/bjp.2022.152","article-title":"The digital redesign of mental health: leveraging connected digital technologies for agency-driven patient-focused care","volume":"222","author":"Goodday","year":"2023","journal-title":"Br J Psychiatry"}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/52\/5\/sbaf201\/65409064\/sbaf201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/52\/5\/sbaf201\/65409064\/sbaf201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:44:35Z","timestamp":1791434675000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article\/doi\/10.1093\/schbul\/sbaf201\/8329341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8,20]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbaf201","relation":{},"ISSN":["0586-7614","1745-1701"],"issn-type":[{"value":"0586-7614","type":"print"},{"value":"1745-1701","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2025,11,20]]},"article-number":"sbaf201"}}