{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:57:31Z","timestamp":1791403051893,"version":"4.3.3"},"reference-count":55,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Network of National Schizophrenia Networks Studying Gene\u2013Environment Interactions","award":["HEALTH-F2-2010-241909"],"award-info":[{"award-number":["HEALTH-F2-2010-241909"]}]},{"name":"European Community\u2019s Seventh Framework Program"},{"name":"Medical Research Council Fellowship","award":["MR\/J008915\/1"],"award-info":[{"award-number":["MR\/J008915\/1"]}]},{"name":"Ministerio de Ciencia, Innovaci\u00f3n e Universidades","award":["PSI2017-87512-C2-1-R"],"award-info":[{"award-number":["PSI2017-87512-C2-1-R"]}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017SGR1612"],"award-info":[{"award-number":["2017SGR1612"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King\u2019s College London"},{"DOI":"10.13039\/100000025","name":"National Institute for Mental Health","doi-asserted-by":"crossref","award":["1R01MH128971-01A1"],"award-info":[{"award-number":["1R01MH128971-01A1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brain volume alterations in those at clinical high risk (CHR) of psychosis have been reported in many studies. However, the association between these alterations and the longitudinal trajectory of changes in symptoms and functioning remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>T1-weighted magnetic resonance imaging (MRI) scans were acquired from 226 CHR and 65 healthy controls (HC) recruited from the EU-GEI high-risk study. Five a priori regions of interest were examined and segmented using FreeSurfer: total gray matter (GM) volume, anterior cingulate cortex (ACC), hippocampus, fusiform gyri, and insula. Brain volumes in the CHR and HC groups were compared at baseline. In the CHR group, linear mixed models were used to investigate the association between baseline brain volume and longitudinal changes in positive symptoms, negative symptoms, and functioning over a 2-year follow-up period. We also compared CHR participants who later transitioned to psychosis (CHR-T, n\u2009=\u200948) and those who did not (CHR-NT, n\u2009=\u2009178) in terms of their trajectory of symptoms and functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Compared with HC, CHR participants had lower total GM and fusiform volume at baseline. Lower total GM and hippocampus volume at baseline were associated with higher levels of positive symptoms at baseline and follow-up in CHR individuals, and lower baseline hippocampus volume also predicted future transition. CHR-T and CHR-NT individuals demonstrated distinct symptoms and functioning trajectories over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that CHR individuals show baseline differences in brain structure compared to HC, which may also predict changes in positive symptoms over the subsequent 2\u00a0years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf231","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:16:58Z","timestamp":1764767818000},"source":"Crossref","is-referenced-by-count":1,"title":["Gray Matter Volume Abnormalities and the Association with the Trajectory of Symptoms and Functioning in Individuals at Clinical High Risk of Psychosis"],"prefix":"10.1093","author":[{"given":"Shuqing","family":"Si","sequence":"first","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry , Psychology & Neuroscience, King's College London, London SE5 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-5495","authenticated-orcid":false,"given":"Cheryl","family":"See","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry , Psychology & Neuroscience, King's College London, London SE5 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-4516","authenticated-orcid":false,"given":"Emily P","family":"Hedges","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry , Psychology & Neuroscience, King's College London, London SE5 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1983-9135","authenticated-orcid":false,"given":"Stefania","family":"Tognin","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry , Psychology & Neuroscience, King's College London, London SE5 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-066X","authenticated-orcid":false,"given":"Gemma","family":"Modinos","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Institute of Psychiatry , Psychology & Neuroscience, King\u2019s College London, London SE5 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieuwe","family":"de Haan","sequence":"additional","affiliation":[{"name":"Department Early Psychosis, AMC, Academic Psychiatric Centre , Meibergdreef 5, 1105 AZ, Amsterdam ,","place":["The Netherlands"]},{"name":"Arkin, 1033 NN Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"van der Gaag","sequence":"additional","affiliation":[{"name":"Faculty of Behavioural and Movement Sciences, Department of Clinical Psychology, VU University , van der Boechorststraat 7, 1081 BT Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Psychosis Research, Parnassia Psychiatric Institute , Zoutkeetsingel 40, The Hague 2512 HN ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnaby","family":"Nelson","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health, University of Melbourne , 35 Poplar Road (Locked Bag 10), Parkville, Melbourne , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-0238","authenticated-orcid":false,"given":"Christos","family":"Pantelis","sequence":"additional","affiliation":[{"name":"Melbourne Neuropsychiatry Centre, University of Melbourne & Melbourne Health , Carlton South, Victoria, 3053 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-8789","authenticated-orcid":false,"given":"Anita","family":"Riecher-R\u00f6ssler","sequence":"additional","affiliation":[{"name":"University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Bressan","sequence":"additional","affiliation":[{"name":"LiNC - Lab Interdisciplinar Neuroci\u00eancias Cl\u00ednicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo \u2013 UNIFESP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-1238","authenticated-orcid":false,"given":"Neus","family":"Barrantes-Vidal","sequence":"additional","affiliation":[{"name":"Departament de Psicologia Cl\u00ednica i de la Salut (Universitat Aut\u00f2noma de Barcelona), Spanish Mental Health Research Network (CIBERSAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Krebs","sequence":"additional","affiliation":[{"name":"University Paris Descartes , H\u00f4pital Sainte-Anne, C\u2019JAAD, Service Hospitalo-Universitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Glenth\u00f8j","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen , Glostrup ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ruhrmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-9877","authenticated-orcid":false,"given":"Gabriele","family":"Sachs","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Department of Psychiatry and Psychotherapy ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart P","family":"Rutten","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Maastricht University Medical Centre, P.O. Box 616, 464, 6200 MD, Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-1586","authenticated-orcid":false,"given":"Jim","family":"van Os","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry , Psychology & Neuroscience, King's College London, London SE5 8AF ,","place":["United Kingdom"]},{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Maastricht University Medical Centre, P.O. 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