{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:01:16Z","timestamp":1780617676882,"version":"3.54.1"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"FAIR\u2014Future AI Research","award":["PE00000013"],"award-info":[{"award-number":["PE00000013"]}]},{"name":"FAIR\u2014Future AI Research","award":["H97G22000210007"],"award-info":[{"award-number":["H97G22000210007"]}]},{"name":"MUR PNRR Extended Partnership program"},{"name":"PRISM","award":["CUP H97G22000320005"],"award-info":[{"award-number":["CUP H97G22000320005"]}]},{"name":"PRISM","award":["SOE_0000127"],"award-info":[{"award-number":["SOE_0000127"]}]},{"name":"Italian Ministry of Health within the Italian network of excellence for advanced diagnosis","award":["PNC-E3-2022-23\u2009683\u2009266"],"award-info":[{"award-number":["PNC-E3-2022-23\u2009683\u2009266"]}]},{"name":"Italian Ministry of Health within the Italian network of excellence for advanced diagnosis","award":["CUP C43C22001630001"],"award-info":[{"award-number":["CUP C43C22001630001"]}]},{"name":"Apulia regional government"},{"name":"Neuroscience and Neuropharmacology","award":["PE00000006"],"award-info":[{"award-number":["PE00000006"]}]},{"name":"Neuroscience and Neuropharmacology","award":["H93C22000660006"],"award-info":[{"award-number":["H93C22000660006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Electroencephalographic (EEG) or magnetoencephalographic (MEG) microstates, ie, discrete spatial configurations of brain signals over time, are thought to reflect the activity of large-scale brain circuits. Altered EEG microstates associated with cognitive control and attention have been consistently reported in schizophrenia (SCZ). However, EEG microstate characterization in other psychiatric disorders and treatment-related modulations are still unclear. MEG microstates (mMSs) have only recently been explored and despite source detection advantages have not been applied to characterize psychiatric disorders so far. Controlling for the impact of treatment, we expected altered mMSs corresponding to brain sources associated with cognitive dysfunction in SCZ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We studied mMSs in a large cohort of controls and patients with SCZ, bipolar disorder (BD), and major depressive disorder (MDD). First, we assessed treatment-related modulations and, after removing treatment bias, we explored anomalies in psychiatric disorders and possible associations with psychopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Benzodiazepine administration was associated with reduced mMS variance and duration, together with increased occurrence across diagnoses. After excluding patients receiving benzodiazepines, patients with SCZ showed increased contribution of occipito-parietal (mMS 1-2) and reduced fronto-temporal and centro-parietal (mMS 3-4) configurations relative to controls. Altered mMSs reflected impairments in brain generators linked to sensory processing and cognitive function. Analyses in BD and MDD, featuring smaller sample sizes, showed no significant differences from controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In summary, we detected mMSs disruptions in patients with SCZ, involving source brain regions associated with sensory integration and cognition. These effects did not depend on pharmacological treatment and were not significant in mood disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbaf239","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:35:44Z","timestamp":1773329744000},"source":"Crossref","is-referenced-by-count":0,"title":["Magnetoencephalographic Microstates Reveal Disrupted Brain Activity Patterns in Schizophrenia Controlling for Treatment-Related Modulations"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8920-5646","authenticated-orcid":false,"given":"Angelantonio","family":"Tavella","sequence":"first","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro , Bari 70124,","place":["Italy"]},{"name":"Department of Mental Health, ASL Bari , Bari 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