{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:13:44Z","timestamp":1789758824501,"version":"4.0.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["PGfAR RP-PG-0612-20002"],"award-info":[{"award-number":["PGfAR RP-PG-0612-20002"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019418","name":"NIHR Maudsley Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019418","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR or the Department of Health and Social Care"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Trials rarely include outcomes co-developed with stakeholders, which creates uncertainty about whether trial endpoints reflect the benefits valued by patients and clinicians. There is therefore a need to explore how stakeholder perspectives might influence the interpretation of trial results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>In a 2-phase study, we first engaged service users and staff to rank outcomes from a recently completed randomized controlled trial of cognitive remediation therapy (CRT). We then used multi-criteria decision modelling to generate value-weighted composite scores and reanalyzed the trial data from three arms: individual CRT, group CRT, and treatment as usual (TAU). This approach allowed us to examine how weighting outcomes differently, according to stakeholder perspectives, might affect the conclusions drawn from the trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Both stakeholder groups prioritized the Global Assessment Scale (primary outcome) and quality of life, but disagreed on the importance of cognition. Reanalyses using weighted composite scores produced the same robust finding as the original trial: CRT delivered in group or one-to-one formats provides significant benefit compared with TAU. Sensitivity analyses applying different stakeholder weights showed the same pattern. However, exploratory analyses revealed that group treatment for the service user weighted composite was not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows how stakeholder values can identify nuances in outcomes depending on the value placed on treatment benefits. Embedding this approach into trial design can strengthen the alignment of outcomes with patient and service priorities and help close the gap between randomized trials and service implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbag006","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:53:29Z","timestamp":1767963209000},"source":"Crossref","is-referenced-by-count":1,"title":["Who Should Decide the Outcome for a Clinical Trial? Comparing the Views of Stakeholders on Intervention Benefit Using Multi-Criteria Decision Modelling of Cognitive Remediation"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-6684","authenticated-orcid":false,"given":"Xiaoyu","family":"Zhang","sequence":"first","affiliation":[{"name":"King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research , London, SE5 8AF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-8003","authenticated-orcid":false,"given":"Til","family":"Wykes","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, Psychology , London, SE5 8AF \u00a0","place":["UK"]},{"name":"South London and Maudsley NHS Foundation Trust , London SE5 8AZ 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Neuroscience, Psychology , London, SE5 8AF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-654X","authenticated-orcid":false,"given":"Imogen","family":"Kilcoyne","sequence":"additional","affiliation":[{"name":"Essex Partnership University NHS Foundation Trust , Wickford, SS11 7XX ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Perez","sequence":"additional","affiliation":[{"name":"Cambridgeshire and Peterborough NHS Foundation Trust , Cambridge, CB21 5EF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7849-4907","authenticated-orcid":false,"given":"Uzma","family":"Zahid","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Institute of Psychiatry Psychology and Neuroscience, Psychology , London, SE5 8AF 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