{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T11:00:12Z","timestamp":1774090812623,"version":"3.50.1"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Health Research Board Psychosis Ireland Structured Training and Research","award":["CDA 2021-0005"],"award-info":[{"award-number":["CDA 2021-0005"]}]},{"DOI":"10.13039\/501100025294","name":"Taighde \u00c9ireann \u2013 Research Ireland","doi-asserted-by":"crossref","award":["21\/RC\/10294_P2"],"award-info":[{"award-number":["21\/RC\/10294_P2"]}],"id":[{"id":"10.13039\/501100025294","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FutureNeuro Research Ireland Centre for Translational Brain Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with first-episode psychosis (FEP) experience increased cardiometabolic risks, contributing to reduced life expectancy. While metabolic disturbances are well described in chronic schizophrenia, their trajectory from first presentation, before or with minimal antipsychotic exposure, through to long-term follow-up remains incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize evidence on progression of cardiometabolic outcomes in FEP cohorts from before initiation of antipsychotic medication to up to 10\u00a0years of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Following PRISMA and MOOSE guidelines (PROSPERO: CRD42023431072), Medline, Embase, PsycInfo, and CINAHL+ were searched to July 2025 for studies of FEP cohorts with \u226428\u00a0days of antipsychotic exposure at baseline. Outcomes included weight, glucose, lipids, blood pressure, metabolic syndrome (MetS), diabetes, and cardiovascular disease (CVD). Random-effects meta-analyses were stratified by follow-up duration. As post-baseline exposure was not quantified, follow-up estimates reflect outcomes under routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>From 2601 unique articles, 82 studies were included. Obesity and MetS prevalence increased from 5.4% and 8.5%, respectively at baseline, to 26.6% and 18.2% at 1\u20133\u00a0years, whereas type 2 diabetes increased from 0.5% to 5.0% by &amp;gt;5\u00a0years. Lipid abnormalities emerged early, while blood pressure changes were minimal, and CVD hospitalization prevalence was 1.4% at 5\u201310\u00a0years. Weight increased by +2.5\u00a0kg at 4\u20138\u00a0weeks and\u2009+\u200913.4\u00a0kg at &amp;gt;5\u00a0years, with parallel increases in BMI and waist circumference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiometabolic deterioration begins within weeks of FEP onset and accumulates over time, indicating the need for early prevention, sustained monitoring, integrated metabolic care, and patient education throughout the course of care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbag008","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T10:19:50Z","timestamp":1774088390000},"source":"Crossref","is-referenced-by-count":0,"title":["Short-, Medium-, and Long-Term Cardiometabolic Outcomes in First-Episode Psychosis: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6200-6726","authenticated-orcid":false,"given":"Anna","family":"Zierotin","sequence":"first","affiliation":[{"name":"School of Medicine, College of Health and Agricultural Sciences, University College Dublin , Dublin 4 , D04 V1W8,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Royal College of Surgeons in Ireland , Dublin 2 , DO2 YN77,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Stano","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Development, Center for Environmental Neuroscience , 14195 Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7420-9339","authenticated-orcid":false,"given":"Michael John","family":"Norton","sequence":"additional","affiliation":[{"name":"Recovery and Engagement Lead, Office of Mental Health Engagement and Recovery, HSE , Dublin , D20 HK69,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R","family":"Cotter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Royal College of Surgeons in Ireland , Dublin 2 , DO2 YN77,","place":["Ireland"]},{"name":"FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences , Dublin 2, D02 YN77, \u00a0","place":["Ireland"]},{"name":"Department of Psychiatry, Beaumont Hospital , Dublin , D09 V2N0,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Royal College of Surgeons in Ireland , Dublin 2 , DO2 YN77,","place":["Ireland"]},{"name":"FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences , Dublin 2, D02 YN77, \u00a0","place":["Ireland"]},{"name":"Department of Psychiatry, Beaumont Hospital , Dublin , D09 V2N0,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"RISE Early Intervention in Psychosis Service, South Lee Mental Health Service , Cork , T12 YR2P,","place":["Ireland"]},{"name":"Department of Psychiatry and Neurobehavioural Science, University College Cork , Cork , T12 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