{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:19:22Z","timestamp":1777987162392,"version":"3.51.4"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000269","name":"Economic and Social Research Council","doi-asserted-by":"publisher","award":["ES\/M001660\/1 and ES\/W013142\/1"],"award-info":[{"award-number":["ES\/M001660\/1 and ES\/W013142\/1"]}],"id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ESRC Centre for Society and Mental Health at King\u2019s College London","award":["ES\/S012567\/1"],"award-info":[{"award-number":["ES\/S012567\/1"]}]},{"name":"Erasmus+ programme","award":["T5-10779"],"award-info":[{"award-number":["T5-10779"]}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH128971"],"award-info":[{"award-number":["MH128971"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Excess mortality in psychotic disorders is largely due to preventable cardiometabolic morbidity. Efforts to evaluate the link between the psychosis spectrum and cardiometabolic health have been confounded by early-life adversity (ELA) and biased sampling. This population-based study examined prospective associations between psychosis-spectrum status and cardiometabolic biomarkers at age 44-45, adjusting for ELA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We analyzed data from the 2002\/03 biomedical sweep of the British National Child Development Study (n\u2009=\u20099377; age 44-45). Psychosis-spectrum status (exposure; n\u2009=\u2009171) was defined using repeated screening across adulthood (ages 23 to 44-45), including self-reported diagnoses, antipsychotic medication use, or professional help-seeking for hallucinations. Cardiometabolic biomarkers at age 44-45 (outcomes) were compared between individuals on the psychosis spectrum and psychosis-free controls (comparator; n\u2009=\u20092448). Analyses were conducted using unimputed and multiply imputed datasets (n\u2009=\u20097391-9298), adjusting for 24 indicators of ELA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>In both unimputed\/imputed analyses, individuals on the psychosis spectrum had significantly worse cardiometabolic profiles. Adjusted results showed elevated abdominal obesity (exp(b), 1.404; 95% CI, 1.177-1.676; P &amp;lt; .001), higher glycated hemoglobin (B\u2009=\u20090.321; 95% CI, 0.089-0.553; P = .008), lower high-density lipoprotein cholesterol (B\u2009=\u2009\u20134.472; 95% CI, \u20137.782 to \u20131.162; P = .009), and increased fibrinogen (B\u2009=\u20094.542; 95% CI, 0.939-8.144; P = .015) compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overcoming early-life confounders and biases that limited prior research, our study demonstrates a robust, independent association between psychosis-spectrum status and cardiometabolic dysfunction at age 44-45. These findings underscore the urgent need for comprehensive screening, treatment, and monitoring of cardiometabolic morbidity in psychosis, guided by a life-course perspective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbag040","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:46:45Z","timestamp":1772714805000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiometabolic Biomarkers at Age 44-45 in the Psychosis Spectrum: The British National Child Development Study"],"prefix":"10.1093","volume":"52","author":[{"given":"Eugenia","family":"Kravariti","sequence":"first","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King\u2019s College London , London SE5 8AF ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Reichenberg","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King\u2019s College London , London SE5 8AF ,","place":["United Kingdom"]},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Fragkaki","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King\u2019s College London , London SE5 8AF ,","place":["United Kingdom"]},{"name":"First Department of Psychiatry, School of Medicine, National and Kapodistrian University of Athens , Athens 115 28 ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin M","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King\u2019s College London , London SE5 8AF 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