{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:29:00Z","timestamp":1786703340926,"version":"build-2736575974"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council-UK","doi-asserted-by":"crossref","award":["MC_U120097115"],"award-info":[{"award-number":["MC_U120097115"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council-UK","doi-asserted-by":"crossref","award":["MR\/W005557\/1"],"award-info":[{"award-number":["MR\/W005557\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council-UK","doi-asserted-by":"crossref","award":["MR\/V013734\/1"],"award-info":[{"award-number":["MR\/V013734\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["094849\/Z\/10\/Z"],"award-info":[{"award-number":["094849\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King\u2019s College London and Sumitomo Pharma America, Inc","award":["NCT04038957"],"award-info":[{"award-number":["NCT04038957"]}]},{"name":"Wellcome Trust Clinical Research Career Development Fellowship","award":["224625\/Z\/21\/Z"],"award-info":[{"award-number":["224625\/Z\/21\/Z"]}]},{"name":"NIHR Oxford Health Biomedical Research Centre"},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Hypothesis<\/jats:title>\n                    <jats:p>Elevated postmortem iron in Brodmann areas 10-11 has recently been linked to schizophrenia. Although in vivo studies have linked subcortical iron abnormalities to disease-related striatal hyperdopaminergia, in vivo cortical iron alterations have not been previously examined. We therefore used neuroimaging to test whether cortical iron is elevated in individuals with schizophrenia and whether this correlated with mesostriatal dopamine function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We acquired quantitative susceptibility mapping magnetic resonance imaging (MRI) to measure magnetic susceptibility (\u03c7), a marker of iron, in 149 participants aged 18-45 (73 with schizophrenia and 76 matched healthy controls). Subsets of patients with schizophrenia underwent [18F]-DOPA PET to estimate striatal dopamine synthesis capacity (n\u00a0=\u200939) and neuromelanin-sensitive MRI of the dopaminergic midbrain (n\u00a0=\u200968), as neuromelanin is a byproduct of dopamine synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Primary analyses showed no significant case\u2013control differences in \u03c7 in the whole cortex (P\u00a0=\u2009.675) or Brodmann areas 10-11 (P\u00a0=\u2009.537). Exploratory analyses examined \u03c7 for 360 cortical regions, correcting for multiple comparisons. Two left temporo-parieto-occipital junction regions showed significantly elevated \u03c7 in schizophrenia: the posterior temporo-parieto-occipital junction the posterior temporo-parieto-occipital junction (d\u00a0=\u20090.752, P\u00a0&amp;lt;\u2009.001) and the superior temporal visual area (d\u00a0=\u20090.638, P\u00a0=\u2009.034). Mean \u03c7 across these regions inversely correlated with dopamine synthesis capacity in the associative (r\u00a0=\u2009\u20130.37, P\u00a0=\u2009.048) and limbic (r\u00a0=\u2009\u20130.34, P\u00a0=\u2009.048) striatum, and with neuromelanin-sensitive MRI values in the dopaminergic midbrain (r\u00a0=\u2009\u20130.35, P\u00a0=\u2009.005), corrected for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the first in vivo evidence of elevated cortical iron in schizophrenia and links this to mesostriatal dopamine dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbag045","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:05:22Z","timestamp":1773234322000},"source":"Crossref","is-referenced-by-count":0,"title":["Cortical Iron and Mesostriatal Dopamine Function in Schizophrenia: A Positron Emission Tomography and Magnetic Resonance Imaging Study"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-490X","authenticated-orcid":false,"given":"Luke James","family":"Vano","sequence":"first","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London , SE5 8AF,","place":["United Kingdom"]},{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London , London , SW7 5NH,","place":["United Kingdom"]},{"name":"South London and Maudsley NHS Foundation Trust , London , SE5 8AZ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sedlacik","sequence":"additional","affiliation":[{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London , London , SW7 5NH,","place":["United Kingdom"]},{"name":"Mansfield Centre for Innovation - MR Facility, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen John","family":"Kaar","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London , SE5 8AF,","place":["United Kingdom"]},{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London , London , SW7 5NH,","place":["United Kingdom"]},{"name":"Division of Psychology and Mental Health, Faculty of Biology, Medicine, and Health, University of Manchester , Manchester , M13 9PL,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Rutigliano","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London , SE5 8AF,","place":["United Kingdom"]},{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London , London , SW7 5NH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London , SE5 8AF,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaine","family":"Berry","sequence":"additional","affiliation":[{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London , London , SW7 5NH,","place":["United Kingdom"]},{"name":"Mansfield Centre for Innovation - MR Facility, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Statton","sequence":"additional","affiliation":[{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London , London , SW7 5NH,","place":["United Kingdom"]},{"name":"Mansfield Centre for Innovation - MR Facility, MRC Laboratory of Medical Sciences, Hammersmith Hospital , London , W12 0HS,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Fazlollahi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Royal Melbourne Hospital, University of Melbourne , Parkville, VIC, 3050 ,","place":["Australia"]},{"name":"Faculty of Health, Medicine and Behavioural Sciences, Queensland Brain Institute, The University of Queensland , St Lucia, QLD, 4067 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Veronese","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging, King's College London , London , SE5 8AF,","place":["United Kingdom"]},{"name":"Department of Information Engineering, University of Padua , 35131, Padova, PD ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver David","family":"Howes","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London , SE5 8AF,","place":["United Kingdom"]},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London , London , SW7 5NH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Ali","family":"McCutcheon","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London , London , SE5 8AF,","place":["United Kingdom"]},{"name":"Department of Psychiatry, University of Oxford , Oxford , OX3 7JX,","place":["United Kingdom"]},{"name":"Oxford Health NHS Foundation Trust, Warneford Hospital , Oxford , OX3 7JX,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026081405133686300_ref1","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.biopsych.2018.04.023","article-title":"Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta analysis (ENIGMA) consortium","volume":"84","author":"Erp","year":"2018","journal-title":"Biol Psychiatry"},{"key":"2026081405133686300_ref2","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1001\/jamapsychiatry.2017.2663","article-title":"Heterogeneity and homogeneity of regional brain structure in schizophrenia: a meta-analysis","volume":"74","author":"Brugger","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"2026081405133686300_ref3","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1001\/archgenpsychiatry.2009.91","article-title":"Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia","volume":"66","author":"Minzenberg","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"2026081405133686300_ref4","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1038\/s41380-023-01979-3","article-title":"Perturbed iron biology in the prefrontal cortex of people with schizophrenia","volume":"28","author":"Lotan","year":"2023","journal-title":"Mol Psychiatry"},{"key":"2026081405133686300_ref5","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.freeradbiomed.2018.09.033","article-title":"Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration","volume":"133","author":"Masaldan","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"2026081405133686300_ref6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroimage.2018.06.007","article-title":"The influence of brain iron and myelin on magnetic susceptibility and effective transverse relaxation - a biochemical and histological validation study","volume":"179","author":"Hametner","year":"2018","journal-title":"NeuroImage."},{"key":"2026081405133686300_ref7","doi-asserted-by":"publisher","first-page":"102736","DOI":"10.1016\/j.nicl.2021.102736","article-title":"Brain iron assessment in patients with First-episode schizophrenia using quantitative susceptibility mapping","volume":"31","author":"Xu","year":"2021","journal-title":"Neuroimage Clin"},{"key":"2026081405133686300_ref8","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1093\/schbul\/sbad041","article-title":"Quantitative susceptibility mapping MRI in deep-brain nuclei in First-episode psychosis","volume":"49","author":"Garc\u00eda Saborit","year":"2023","journal-title":"Schizophr Bull"},{"key":"2026081405133686300_ref9","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1176\/appi.ajp.20240512","article-title":"Reduced brain iron and striatal Hyperdopaminergia in schizophrenia: a quantitative susceptibility mapping MRI and PET study","volume":"182","author":"Vano","year":"2025","journal-title":"AJP."},{"key":"2026081405133686300_ref10","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s41380-025-03195-7","article-title":"The role of low subcortical iron, white matter myelin, and oligodendrocytes in schizophrenia: a quantitative susceptibility mapping and diffusion tensor imaging study","volume":"31","author":"Vano","year":"2025","journal-title":"Mol Psychiatry"},{"key":"2026081405133686300_ref11","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1093\/brain\/awp125","article-title":"Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome","volume":"132","author":"Connor","year":"2009","journal-title":"Brain."},{"key":"2026081405133686300_ref12","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.expneurol.2014.06.023","article-title":"Low brain iron effects and reversibility on striatal dopamine dynamics","volume":"261","author":"Unger","year":"2014","journal-title":"Exp Neurol"},{"key":"2026081405133686300_ref13","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/jn\/137.1.118","article-title":"Early iron deficiency alters sensorimotor development and brain monoamines in rats","volume":"137","author":"Unger","year":"2007","journal-title":"J Nutr"},{"key":"2026081405133686300_ref14","doi-asserted-by":"publisher","first-page":"114158","DOI":"10.1016\/j.expneurol.2022.114158","article-title":"Brain-iron deficiency models of restless legs syndrome","volume":"356","author":"Earley","year":"2022","journal-title":"Exp Neurol"},{"key":"2026081405133686300_ref15","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.jnutbio.2014.07.003","article-title":"Iron and mechanisms of emotional behavior","volume":"25","author":"Kim","year":"2014","journal-title":"J Nutr Biochem"},{"key":"2026081405133686300_ref16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.pneurobio.2015.09.012","article-title":"Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson\u2019s disease","volume":"155","author":"Zucca","year":"2017","journal-title":"Prog Neurobiol"},{"key":"2026081405133686300_ref17","volume-title":"Structured Clinical Interview for DSM-5 Disorders \u2013 Clinician Version (SCID-5-CV)","author":"First","year":"2016"},{"key":"2026081405133686300_ref18","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1093\/jat\/23.5.323","article-title":"Urinary excretion of 11-nor-9-carboxy-delta9-tetrahydrocannabinol and cannabinoids in frequent and infrequent drug users","volume":"23","author":"Smith-Kielland","year":"1999","journal-title":"J Anal Toxicol"},{"key":"2026081405133686300_ref19","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"2026081405133686300_ref20","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1093\/schbul\/sbq059","article-title":"The brief negative symptom scale: psychometric properties","volume":"37","author":"Kirkpatrick","year":"2011","journal-title":"Schizophr Bull"},{"key":"2026081405133686300_ref21","first-page":"28","article-title":"The clinical global impressions scale: applying a research tool in clinical practice","volume":"4","author":"Busner","year":"2007","journal-title":"Psychiatry (Edgmont)"},{"key":"2026081405133686300_ref22","doi-asserted-by":"publisher","first-page":"S90","DOI":"10.1093\/schbul\/sbv167","article-title":"Dose equivalents for antipsychotic drugs: the DDD method","volume":"42","author":"Leucht","year":"2016","journal-title":"Schizophr Bull"},{"key":"2026081405133686300_ref23","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1002\/mrm.30006","article-title":"Recommended implementation of quantitative susceptibility mapping for clinical research in the brain: a consensus of the ISMRM electro-magnetic tissue properties study group","volume":"91","author":"QSM Consensus Organization Committee","year":"2024","journal-title":"Magn Reson Med"},{"key":"2026081405133686300_ref24","doi-asserted-by":"publisher","DOI":"10.3791\/62493","article-title":"Standardized data Acquisition for Neuromelanin-sensitive Magnetic Resonance Imaging of the substantia nigra","volume":"175","author":"Salzman","year":"2021","journal-title":"J Vis Exp"},{"key":"2026081405133686300_ref25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"2026081405133686300_ref26","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage."},{"key":"2026081405133686300_ref27","doi-asserted-by":"publisher","first-page":"024003","DOI":"10.1117\/1.JMI.1.2.024003","article-title":"Global image registration using a symmetric block-matching approach","volume":"1","author":"Modat","year":"2014","journal-title":"J Med Imaging (Bellingham)"},{"key":"2026081405133686300_ref28","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/mrm.24272","article-title":"Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping","volume":"69","author":"Liu","year":"2013","journal-title":"Magn Reson Med"},{"key":"2026081405133686300_ref29","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/nbm.1670","article-title":"A novel background field removal method for MRI using projection onto dipole fields (PDF)","volume":"24","author":"Liu","year":"2011","journal-title":"NMR Biomed"},{"key":"2026081405133686300_ref30","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1002\/mrm.28377","article-title":"An optimized and highly repeatable MRI acquisition and processing pipeline for quantitative susceptibility mapping in the head-and-neck region","volume":"84","author":"Karsa","year":"2020","journal-title":"Magn Reson Med"},{"key":"2026081405133686300_ref31","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jpsychires.2022.04.013","article-title":"Subcortical brain iron deposition in individuals with schizophrenia","volume":"151","author":"Sonnenschein","year":"2022","journal-title":"J Psychiatr Res"},{"key":"2026081405133686300_ref32","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s00429-021-02421-6","article-title":"An extended human connectome project multimodal parcellation atlas of the human cortex and subcortical areas","volume":"227","author":"Huang","year":"2022","journal-title":"Brain Struct Funct"},{"key":"2026081405133686300_ref33","volume-title":"sMRIPrep: Structural MRI PREProcessing Workflows [Internet]","author":"Esteban","year":"2024"},{"key":"2026081405133686300_ref34","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1006\/nimg.1998.0396","article-title":"Cortical surface-based analysis: II: inflation, flattening, and a surface-based coordinate system","volume":"9","author":"Fischl","year":"1999","journal-title":"NeuroImage."},{"key":"2026081405133686300_ref35","doi-asserted-by":"publisher","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026081405133686300_ref36","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.biopsych.2024.06.013","article-title":"Mesostriatal dopaminergic circuit dysfunction in schizophrenia: a multimodal neuromelanin-sensitive magnetic resonance imaging and [18F]-DOPA positron emission tomography study","volume":"96","author":"Vano","year":"2024","journal-title":"Biol Psychiatry"},{"key":"2026081405133686300_ref37","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat Methods"},{"key":"2026081405133686300_ref38","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1177\/02698811221122031","article-title":"The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [18F]-FDOPA imaging in schizophrenia","volume":"36","author":"Angelescu","year":"2022","journal-title":"J Psychopharmacol"},{"key":"2026081405133686300_ref39","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.biopsych.2018.07.003","article-title":"The effects of antipsychotic treatment on presynaptic dopamine synthesis capacity in First-episode psychosis: a positron emission tomography study","volume":"85","author":"Jauhar","year":"2019","journal-title":"Biol Psychiatry"},{"key":"2026081405133686300_ref40","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/jcbfm.1991.154","article-title":"L-6-[18F]fluoro-dopa metabolism in monkeys and humans: biochemical parameters for the formulation of tracer kinetic models with positron emission tomography","volume":"11","author":"Melega","year":"1991","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026081405133686300_ref41","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.neuroimage.2009.12.058","article-title":"The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function","volume":"50","author":"Egerton","year":"2010","journal-title":"Neuroimage."},{"key":"2026081405133686300_ref42","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1177\/0271678X231168687","article-title":"An automatic analysis framework for FDOPA PET neuroimaging","volume":"43","author":"Nordio","year":"2023","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026081405133686300_ref43","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/01.WCB.0000048520.34839.1A","article-title":"Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum","volume":"23","author":"Martinez","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026081405133686300_ref44","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1097\/00004647-199911000-00003","article-title":"Multiresolution analysis of emission tomography images in the wavelet domain","volume":"19","author":"Turkheimer","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026081405133686300_ref45","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.neuroimage.2011.10.025","article-title":"SPM: a history","volume":"62","author":"Ashburner","year":"2012","journal-title":"Neuroimage."},{"key":"2026081405133686300_ref46","doi-asserted-by":"publisher","first-page":"118102","DOI":"10.1016\/j.neuroimage.2021.118102","article-title":"Quantitative MRI susceptibility mapping reveals cortical signatures of changes in iron, calcium and zinc in malformations of cortical development in children with drug-resistant epilepsy","volume":"238","author":"Lorio","year":"2021","journal-title":"Neuroimage."},{"key":"2026081405133686300_ref47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage."},{"key":"2026081405133686300_ref48","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1002\/hbm.24977","article-title":"Depth-dependent abnormal cortical myelination in first-episode treatment-na\u00efve schizophrenia","volume":"41","author":"Wei","year":"2020","journal-title":"Hum Brain Mapp"},{"key":"2026081405133686300_ref49","doi-asserted-by":"publisher","first-page":"100689","DOI":"10.1016\/j.jadr.2023.100689","article-title":"A systematic review of abnormalities in intracortical myelin across psychiatric illnesses","volume":"15","author":"Chen","year":"2024","journal-title":"J Affect Disord Rep"},{"key":"2026081405133686300_ref50","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00429-022-02600-z","article-title":"Mapping myelin in white matter with T1-weighted\/T2-weighted maps: discrepancy with histology and other myelin MRI measures","volume":"228","author":"Sandrone","year":"2023","journal-title":"Brain Struct Funct"},{"key":"2026081405133686300_ref51","doi-asserted-by":"publisher","first-page":"7228","DOI":"10.1038\/s41598-024-57287-5","article-title":"Association between T1w\/T2w ratio in white matter and cognitive function in Alzheimer\u2019s disease","volume":"14","author":"Lee","year":"2024","journal-title":"Sci Rep"},{"key":"2026081405133686300_ref52","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.schres.2007.05.038","article-title":"A reduced number of cortical neurons show increased caldendrin protein levels in chronic schizophrenia","volume":"96","author":"Bernstein","year":"2007","journal-title":"Schizophr Res"},{"key":"2026081405133686300_ref53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41537-022-00293-1","article-title":"In vivo 7-tesla MRI investigation of brain iron and its metabolic correlates in chronic schizophrenia","volume":"8","author":"Ravanfar","year":"2022","journal-title":"Schizophr."},{"key":"2026081405133686300_ref54","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.1038\/s41380-022-01740-2","article-title":"Decreased basal ganglia and thalamic iron in early psychotic spectrum disorders are associated with increased psychotic and schizotypal symptoms","volume":"27","author":"Sui","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2026081405133686300_ref55","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1176\/appi.ajp.2015.15070922","article-title":"Accelerated brain aging in schizophrenia: a longitudinal pattern recognition study","volume":"173","author":"Schnack","year":"2016","journal-title":"Am J Psychiatry"},{"key":"2026081405133686300_ref56","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1176\/appi.ajp.2016.16050610","article-title":"Accelerated Gray and white matter deterioration with age in schizophrenia","volume":"174","author":"Cropley","year":"2017","journal-title":"Am J Psychiatry"},{"key":"2026081405133686300_ref57","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1586\/14737175.8.7.1049","article-title":"Voxel-based morphometry in schizophrenia: implications for neurodevelopmental connectivity models, cognition and affect","volume":"8","author":"Williams","year":"2008","journal-title":"Expert Rev Neurother"},{"key":"2026081405133686300_ref58","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.schres.2015.01.032","article-title":"Grey matter volume differences in non-affective psychosis and the effects of age of onset on grey matter volumes: a voxelwise study","volume":"164","author":"Tordesillas-Gutierrez","year":"2015","journal-title":"Schizophr Res"},{"key":"2026081405133686300_ref59","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.biopsych.2009.11.017","article-title":"Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the Temporo-parietal area","volume":"67","author":"Vercammen","year":"2010","journal-title":"Biol Psychiatry"},{"key":"2026081405133686300_ref60","doi-asserted-by":"publisher","first-page":"2470547018815232","DOI":"10.1177\/2470547018815232","article-title":"Temporoparietal junction functional connectivity in early schizophrenia and major depressive disorder","volume":"2","author":"Penner","year":"2018","journal-title":"Chronic Stress"},{"key":"2026081405133686300_ref61","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/schbul\/sbv114","article-title":"Effects of Fronto-temporal transcranial direct current stimulation on auditory verbal hallucinations and resting-state functional connectivity of the left Temporo-parietal junction in patients with schizophrenia","volume":"42","author":"Mondino","year":"2016","journal-title":"Schizophr Bull"},{"key":"2026081405133686300_ref62","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/joa.12204","article-title":"Anatomo-functional study of the temporo-parieto-occipital region: dissection, tractographic and brain mapping evidence from a neurosurgical perspective","volume":"225","author":"De Benedictis","year":"2014","journal-title":"J Anat"},{"key":"2026081405133686300_ref63","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/npp.2016.258","article-title":"Presynaptic dopamine capacity in patients with treatment-resistant schizophrenia taking clozapine: an [18F]DOPA PET study","volume":"42","author":"Kim","year":"2017","journal-title":"Neuropsychopharmacology."},{"key":"2026081405133686300_ref64","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1176\/appi.ajp.2012.12010144","article-title":"Dopamine synthesis capacity in patients with treatment-resistant schizophrenia","volume":"169","author":"Demjaha","year":"2012","journal-title":"AJP."},{"key":"2026081405133686300_ref65","doi-asserted-by":"crossref","DOI":"10.64898\/2026.01.15.26344182","article-title":"Grey matter iron and neuromelanin in psychosis: a systematic review and meta-analysis of MRI studies [internet]","author":"Vano","year":"2026"},{"key":"2026081405133686300_ref66","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/bpa.12704","article-title":"Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP\/PS1 mice","volume":"29","author":"McIntosh","year":"2019","journal-title":"Brain Pathol"},{"key":"2026081405133686300_ref67","doi-asserted-by":"publisher","first-page":"1345349","DOI":"10.3389\/fncel.2024.1345349","article-title":"Microglia-neuron interactions in schizophrenia","volume":"18","author":"Hartmann","year":"2024","journal-title":"Front Cell Neurosci"},{"key":"2026081405133686300_ref68","doi-asserted-by":"publisher","first-page":"618435","DOI":"10.3389\/fnins.2021.618435","article-title":"Systematic review: quantitative susceptibility mapping (QSM) of brain iron profile in neurodegenerative diseases","volume":"15","author":"Ravanfar","year":"2021","journal-title":"Front Neurosci"},{"key":"2026081405133686300_ref69","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1523\/JNEUROSCI.2434-19.2020","article-title":"Longitudinal development of brain iron is linked to cognition in youth","volume":"40","author":"Larsen","year":"2020","journal-title":"J Neurosci"}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/52\/4\/sbag045\/69839984\/sbag045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/52\/4\/sbag045\/69839984\/sbag045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:37:37Z","timestamp":1786700257000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article\/doi\/10.1093\/schbul\/sbag045\/8740223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,3]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbag045","relation":{},"ISSN":["0586-7614","1745-1701"],"issn-type":[{"value":"0586-7614","type":"print"},{"value":"1745-1701","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"sbag045"}}