{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:13:10Z","timestamp":1778314390941,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH44801 to E. J. B."],"award-info":[{"award-number":["MH44801 to E. J. 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It is unclear what proportion of individuals\u2019 exhibit early persistent psychosis and the long-term implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>An epidemiologic sample of individuals with acute psychosis was recruited at first admission and followed for 25\u00a0years. Early persistent psychosis was defined as presence of active psychosis for \u226590% of the days of the 4 years after first hospitalization for psychosis. Multivariable regression analyses were conducted, testing the association between baseline predictors and persistent psychosis, and between persistent psychosis and 25-year outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>Out of 526 individuals (age\u2009=\u200927.4\u2009\u00b1\u20099.4\u00a0years, males\u2009=\u200956.8%, baseline schizophrenia\/schizoaffective disorder\u2009=\u200930.0%), 101 (19.2%) had early persistent psychosis. At baseline, low premorbid cognitive performance (odds ratio (OR)\u2009=\u20092.08, 95% CI,\u00a01.05-4.12), lower Global Assessment of Functioning (OR\u2009=\u20091.59, 95% CI,\u00a01.16-2.13), low role function (OR\u2009=\u20091.49, 95% CI,\u00a01.03-2.16) and worse social function (OR\u2009=\u20091.52, 95% CI,\u00a01.03-2.22) were predictive of persistent psychosis. At 25-year follow-up (n\u2009=\u2009307, 58.9%), early persistent psychosis was associated with worse avolition ($\\beta$=0.25, 95% CI,\u00a00.14-0.35), more severe reality distortion ($\\beta$=0.19, 95% CI,\u00a00.07-0.31), disorganization ($\\beta$=0.21, 95% CI,\u00a00.09-0.32), worse social ($\\beta$=-0.18, 95% CI, -0.06 to -0.30), role ($\\beta$=-0.22, 95% CI,\u00a0-0.09 to -0.34), and global function ($\\beta$=-0.28, 95% CI,\u00a0-0.17 to -0.38), greater odds of being on public assistance (OR\u2009=\u20092.13, 95% CI,\u00a01.15-3.95), lower odds of living independently (OR\u2009=\u20090.43, 95% CI,\u00a00.23-0.80) or recovery (OR\u2009=\u20090.09, 95% CI,\u00a00.02-0.38).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One in 5 individuals with first-episode psychosis had early persistent psychosis without clearly modifiable premorbid factors, and with strong associations with adverse long-term outcomes. Individuals experiencing early persistent psychosis require focused long-term interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/schbul\/sbag049","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:37:16Z","timestamp":1773751036000},"source":"Crossref","is-referenced-by-count":0,"title":["Persistent Psychosis During 4\u00a0Years after First Hospitalization for a Psychotic Disorder in the Suffolk County Mental Health Project: Prevalence, Risk Factors, and Relationship to 25-Year Outcomes"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0056-4135","authenticated-orcid":false,"given":"Jose M","family":"Rubio","sequence":"first","affiliation":[{"name":"The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks , New York 11004, \u00a0","place":["United States"]},{"name":"The Feinstein Institute for Medical Research, Institute of Behavioral Science, Manhasset , New York 11004, \u00a0","place":["United States"]},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , 500 Hofstra Blvd, Hempstead, NY 11549 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxuan","family":"Lian","sequence":"additional","affiliation":[{"name":"Stony Brook University, Department of Applied Mathematics, Stony Brook , 39 John S. 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