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Birth weight (BW), a marker of the intrauterine environment and development, and its genetic proxy\u2014the polygenic risk score for BW (PRSBW)\u2014may influence these trajectories. This study investigated whether PRSBW and BW are associated with the progression of AIWG and fasting glucose levels over 24\u00a0months in individuals with FEP.<\/jats:p>\n                  <jats:p>Study Design: A total of 277 FEP patients with genetic, BW and longitudinal metabolic data were included. Linear mixed-effects models assessed associations of BW and the PRSBW with mean AIWG and glucose, as well as interactions with time. BW was analyzed both as a continuous variable and categorically (Lower\/Higher vs. Intermediate BW).<\/jats:p>\n                  <jats:p>Study Results: BW was significantly associated with mean AIWG across 24\u00a0months (p=.009), with higher BW linked to greater AIWG. In contrast, neither BW nor the PRSBW were associated with mean fasting glucose levels. Significant time\u00d7BW and time\u00d7PRSBW interaction effects emerged for AIWG (p=2.2e-06 and p=4.6e-04, respectively), indicating steeper AIWG trajectories in individuals with higher BW or PRSBW.<\/jats:p>\n                  <jats:p>Conclusions: Our findings suggest that both BW and PRSBW influence the progression of AIWG in early stages of psychosis, reinforcing the role of early-life, both environmental and genetic, factors in shaping metabolic vulnerability. The consistent association between BW-related markers and AIWG highlights their potential value for early risk stratification and targeted prevention of adverse metabolic outcomes.<\/jats:p>","DOI":"10.1093\/schbul\/sbag051","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:40:33Z","timestamp":1773924033000},"source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Impact of Birthweight and its Polygenic Risk Score on Glucose and Antipsychotic-Induced Weight Gain in First Episode Psychosis"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1295-6822","authenticated-orcid":false,"given":"Nora","family":"Guasch-Capella","sequence":"first","affiliation":[{"name":"Barcelona Cl\u00ednic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Cl\u00ednic de Barcelona , Villarroel, 170 08036 Barcelona ,","place":["Spain"]},{"name":"Institut d'investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) 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