{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:38:26Z","timestamp":1786700306212,"version":"build-2736575974"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"2022 MRC\/NIHR CARP","award":["MR\/W029987\/1"],"award-info":[{"award-number":["MR\/W029987\/1"]}]},{"name":"Department of Psychiatry at the University of Cambridge"},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024749","name":"NIHR Applied Research Collaboration East of England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clozapine is a pharmacological treatment with strong evidence for treatment-resistant schizophrenia (TRS), yet it continues to be under-prescribed, initiated late, and offered to a minority of eligible patients. This treatment gap is felt most acutely in early intervention in psychosis (EIP) services. The accompanying study by Conaty et\u00a0al. examines the clinico-demographic correlates of community versus hospital clozapine initiation in a first-episode psychosis (FEP) population. Over half of clozapine treated patients were initiated in the community, and this was associated with substantially lower discontinuation rates. This commentary situates those findings within the wider barriers literature in first episode psychosis, considers the emerging role of virtual wards and remote monitoring in facilitating community-based initiation, and outlines implications for service design and future research.<\/jats:p>","DOI":"10.1093\/schbul\/sbag083","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:44:34Z","timestamp":1777376674000},"source":"Crossref","is-referenced-by-count":0,"title":["Clozapine Beyond Walls: Community Clozapine Initiation in Early Psychosis"],"prefix":"10.1093","volume":"52","author":[{"given":"Rajeev","family":"Krishnadas","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Herschel Smith Bldg , Robinson Way, Cambridge CB2 0SZ ,","place":["United 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to clozapine prescription on the clinical outcome","volume":"268","author":"Mu\u00f1oz-Manchado","year":"2024","journal-title":"Schizophr Res"},{"key":"2026081405130698700_ref10","article-title":"Identifying clinical characteristics of young people with treatment-resistant schizophrenia undergoing community initiation of clozapine","author":"Conaty","journal-title":"Schizophr Bull"},{"key":"2026081405130698700_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/eip.13578","article-title":"Identifying and managing treatment resistance early with the integration of a clozapine clinic within an early intervention for psychosis service","volume":"19","author":"O\u2019Donoghue","year":"2024","journal-title":"Early Intervention in Psychiatry"},{"key":"2026081405130698700_ref12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/eip.12683","article-title":"Delays and barriers to the commencement of clozapine in eligible people with a psychotic disorder: a literature 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