{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:20:12Z","timestamp":1774261212162,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1093\/schbul\/sbr195","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T02:08:18Z","timestamp":1327630098000},"page":"807-814","source":"Crossref","is-referenced-by-count":74,"title":["Dopaminergic Function in the Psychosis Spectrum: An [18F]-DOPA Imaging Study in Healthy Individuals With Auditory Hallucinations"],"prefix":"10.1093","volume":"39","author":[{"given":"Oliver D.","family":"Howes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Shotbolt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bloomfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirstin","family":"Daalman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsime","family":"Demjaha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M. J.","family":"Diederen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euitae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 S.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris E.","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,1,26]]},"reference":[{"key":"key\n\t\t\t\t20170512041006_bib1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0033291708003814","article-title":"A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder","volume":"39","author":"van Os","year":"2009","journal-title":"Psychol Med"},{"key":"key\n\t\t\t\t20170512041006_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00789221","article-title":"Distributions of hallucinations in the population","volume":"26","author":"Tien","year":"1991","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"key\n\t\t\t\t20170512041006_bib3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/schbul\/sbn130","article-title":"Healthy individuals with auditory verbal hallucinations; who are they? Psychiatric assessments of a selected sample of 103 subjects","volume":"36","author":"Sommer","year":"2010","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512041006_bib4","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4088\/JCP.09m05797yel","article-title":"The same or different? A phenomenological comparison of auditory verbal hallucinations in healthy and psychotic individuals","volume":"72","author":"Daalman","year":"2011","journal-title":"J Clin Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib5","doi-asserted-by":"crossref","first-page":"s13","DOI":"10.1192\/bjp.191.51.s13","article-title":"Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis","volume":"51","author":"Howes","year":"2007","journal-title":"Br J Psychiatry Suppl"},{"key":"key\n\t\t\t\t20170512041006_bib6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/026988119901300405","article-title":"Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies","volume":"13","author":"Laruelle","year":"1999","journal-title":"J Psychopharmacol"},{"key":"key\n\t\t\t\t20170512041006_bib7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S1461145704004110","article-title":"Do we still believe in the dopamine hypothesis? New data bring new evidence","volume":"7","author":"Abi-Dargham","year":"2004","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20170512041006_bib8","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.2174\/138161209788957528","article-title":"Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging","volume":"15","author":"Howes","year":"2009","journal-title":"Curr Pharm Des"},{"key":"key\n\t\t\t\t20170512041006_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/09540260701502468","article-title":"The role of dopamine for the pathophysiology of schizophrenia","volume":"19","author":"Meisenzahl","year":"2007","journal-title":"Int Rev Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib10","doi-asserted-by":"crossref","first-page":"11651","DOI":"10.1073\/pnas.91.24.11651","article-title":"Elevated dopa decarboxylase activity in living brain of patients with psychosis","volume":"91","author":"Reith","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170512041006_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.schres.2005.01.003","article-title":"From dopamine to salience to psychosis\u2013linking biology, pharmacology and phenomenology of psychosis","volume":"79","author":"Kapur","year":"2005","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512041006_bib12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/schbul\/sbp006","article-title":"The dopamine hypothesis of schizophrenia: version III\u2014the final common pathway","volume":"35","author":"Howes","year":"2009","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512041006_bib13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(09)60995-8","article-title":"Schizophrenia","volume":"374","author":"van Os","year":"2009","journal-title":"Lancet"},{"issue":"12","key":"key\n\t\t\t\t20170512041006_bib14","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1176\/appi.ajp.2011.11010160","article-title":"Dopamine synthesis capacity before onset of psychosis: a prospective [18]-DOPA PET imaging study","volume":"168","author":"Howes","year":"2011","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archpsyc.1992.01820080023004","article-title":"The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology","volume":"49","author":"Andreasen","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib16","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1001\/archpsyc.1992.01820080032005","article-title":"The Structured Clinical Interview for DSM-III-R (SCID). I: history, rationale, and description","volume":"49","author":"Spitzer","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib17","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/schbul\/17.4.555","article-title":"The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria","volume":"17","author":"Raine","year":"1991","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512041006_bib18","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/oxfordjournals.schbul.a007116","article-title":"Measuring delusional ideation: the 21-item Peters et al. Delusions Inventory (PDI)","volume":"30","author":"Peters","year":"2004","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512041006_bib19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1017\/S0033291799008661","article-title":"Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS)","volume":"29","author":"Haddock","year":"1999","journal-title":"Psychol Med"},{"key":"key\n\t\t\t\t20170512041006_bib20","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0883-2889(92)90217-3","article-title":"Regioselective radiofluorodestannylation with [18F]F2 and [18F]CH3COOF: a high yield synthesis of 6-[18F]Fluoro-L-DOPA","volume":"43","author":"Namavari","year":"1992","journal-title":"Int J Radiat Appl Instr A"},{"key":"key\n\t\t\t\t20170512041006_bib21","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/00004647-199911000-00003","article-title":"Multiresolution analysis of emission tomography images in the wavelet domain","volume":"19","author":"Turkheimer","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20170512041006_bib22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.schres.2008.09.011","article-title":"Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging","volume":"106","author":"Bose","year":"2008","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512041006_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1118\/1.598130","article-title":"Automated three-dimensional registration of magnetic resonance and positron emission tomography brain images by multiresolution optimization of voxel similarity measures","volume":"24","author":"Studholme","year":"1997","journal-title":"Med Phys"},{"key":"key\n\t\t\t\t20170512041006_bib24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1177\/1073858409338217","article-title":"PET studies of cerebral levodopa metabolism: a review of clinical findings and modeling approaches","volume":"15","author":"Kumakura","year":"2009","journal-title":"Neuroscientist"},{"key":"key\n\t\t\t\t20170512041006_bib25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hbm.10123","article-title":"Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe","volume":"19","author":"Hammers","year":"2003","journal-title":"Hum Brain Mapp"},{"key":"key\n\t\t\t\t20170512041006_bib26","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.neuroimage.2009.12.058","article-title":"The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function","volume":"50","author":"Egerton","year":"2009","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170512041006_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jchemneu.2003.10.003","article-title":"The primate basal ganglia: parallel and integrative networks","volume":"26","author":"Haber","year":"2003","journal-title":"J Chem Neuroanat"},{"key":"key\n\t\t\t\t20170512041006_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/archgenpsychiatry.2008.514","article-title":"Elevated striatal dopamine function linked to prodromal signs of schizophrenia","volume":"66","author":"Howes","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jcbfm.1983.1","article-title":"Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data","volume":"3","author":"Patlak","year":"1983","journal-title":"J Cereb Blood Flow Metab"},{"key":"key\n\t\t\t\t20170512041006_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuroimage.2006.03.002","article-title":"Multi-resolution Bayesian regression in PET dynamic studies using wavelets","volume":"32","author":"Turkheimer","year":"2006","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170512041006_bib31","article-title":"Auditory hallucinations elicit similar brain activation in psychotic and nonpsychotic individuals. [published online ahead of print April 28, 2011]","author":"Diederen","year":"2011","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512041006_bib32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/archpsyc.61.2.134","article-title":"Presynaptic dopaminergic dysfunction in schizophrenia: a positron emission tomographic [18F]fluorodopa study","volume":"61","author":"McGowan","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib33","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1017\/S0033291711000341","article-title":"Striatal dopamine synthesis capacity in twins discordant for schizophrenia","volume":"41","author":"Shotbolt","year":"2011","journal-title":"Psychol Med"},{"key":"key\n\t\t\t\t20170512041006_bib34","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biopsych.2007.04.017","article-title":"Striatal dopamine synthesis in first-degree relatives of patients with schizophrenia","volume":"63","author":"Huttunen","year":"2007","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib35","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archpsyc.57.11.1053","article-title":"Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study","volume":"57","author":"Poulton","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib36","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S0140-6736(95)91801-9","article-title":"Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients","volume":"346","author":"Hietala","year":"1995","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170512041006_bib37","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.biopsych.2004.01.018","article-title":"Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide","volume":"55","author":"Abi-Dargham","year":"2004","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170512041006_bib38","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/mp.2011.20","article-title":"Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study","volume":"16","author":"Howes","year":"2011","journal-title":"Mol Psychiatry"}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/39\/4\/807\/12962371\/sbr195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T05:21:49Z","timestamp":1503552109000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-lookup\/doi\/10.1093\/schbul\/sbr195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,26]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,1,26]]},"published-print":{"date-parts":[[2013,7]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbr195","relation":{},"ISSN":["1745-1701","0586-7614"],"issn-type":[{"value":"1745-1701","type":"electronic"},{"value":"0586-7614","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1,26]]}}}