{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:05:24Z","timestamp":1790622324869,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1093\/schbul\/sbt071","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T03:15:36Z","timestamp":1369797336000},"page":"575-584","source":"Crossref","is-referenced-by-count":44,"title":["Chronic Exposure of Mutant DISC1 Mice to Lead Produces Sex-Dependent Abnormalities Consistent With Schizophrenia and Related Mental Disorders: A Gene-Environment Interaction Study"],"prefix":"10.1093","volume":"40","author":[{"given":"Bagrat","family":"Abazyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Dziedzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kegang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofya","family":"Abazyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail V.","family":"Pletnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas R.","family":"Guilarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"key\n\t\t\t\t20170512041426_CIT0001","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/09638237.2010.492417","article-title":"Are psychiatric diagnoses of psychosis scientific and useful? The case of schizophrenia","volume":"19","author":"Van Os","year":"2010","journal-title":"J Ment Health (Abingdon, England)"},{"key":"key\n\t\t\t\t20170512041426_CIT0002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.09.003","article-title":"The environment and susceptibility to schizophrenia","volume":"93","author":"Brown","year":"2011","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t20170512041426_CIT0003","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/mp.2009.144","article-title":"Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders","volume":"16","author":"Ayhan","year":"2011","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170512041426_CIT0004","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbr.2009.04.010","article-title":"Animal models of gene-environment interactions in schizophrenia","volume":"204","author":"Ayhan","year":"2009","journal-title":"Behav Brain Res"},{"key":"key\n\t\t\t\t20170512041426_CIT0005","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/sj.mp.4002079","article-title":"Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia","volume":"13","author":"Pletnikov","year":"2008","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170512041426_CIT0006","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0920-9964(03)00062-8","article-title":"Air pollution from traffic and schizophrenia risk","volume":"66","author":"Pedersen","year":"2004","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512041426_CIT0007","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-244X-6-2","article-title":"Urbanization and traffic related exposures as risk factors for schizophrenia","volume":"6","author":"Pedersen","year":"2006","journal-title":"BMC Psychiatry"},{"key":"key\n\t\t\t\t20170512041426_CIT0008","first-page":"560","article-title":"Is lead exposure in early life an environmental risk factor for schizophrenia? Neurobiological connections and testable hypotheses","volume":"33","author":"Guilarte","year":"2012","journal-title":"Neuro- toxicology"},{"key":"key\n\t\t\t\t20170512041426_CIT0009","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1289\/ehp.6777","article-title":"Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia","volume":"112","author":"Opler","year":"2004","journal-title":"Environ Health Perspect"},{"key":"key\n\t\t\t\t20170512041426_CIT0010","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1289\/ehp.10464","article-title":"Prenatal exposure to lead, delta-aminolevulinic acid, and schizophrenia: further evidence","volume":"116","author":"Opler","year":"2008","journal-title":"Environ Health Perspect"},{"key":"key\n\t\t\t\t20170512041426_CIT0011","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.brainresrev.2005.02.004","article-title":"Lead neurotoxicity: from exposure to molecular effects","volume":"49","author":"Toscano","year":"2005","journal-title":"Brain Res Brain Res Rev"},{"key":"key\n\t\t\t\t20170512041426_CIT0012","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12035-010-8146-0","article-title":"Molecular neurobiology of lead (Pb(2+)): effects on synaptic function","volume":"42","author":"Neal","year":"2010","journal-title":"Mol Neurobiol"},{"key":"key\n\t\t\t\t20170512041426_CIT0013","first-page":"1356","article-title":"Divalent cations modulate N-methyl-D-aspartate receptor function at the glycine site","volume":"290","author":"Hashemzadeh-Gargari","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170512041426_CIT0014","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nn.2487","article-title":"Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1","volume":"13","author":"Hayashi-Takagi","year":"2010","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170512041426_CIT0015","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/mp.2012.97","article-title":"Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion","volume":"18","author":"Ma","year":"2013","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170512041426_CIT0016","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.neuroscience.2006.12.040","article-title":"Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats","volume":"145","author":"Verina","year":"2007","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170512041426_CIT0017","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.biopsych.2010.09.022","article-title":"Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology","volume":"68","author":"Abazyan","year":"2010","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170512041426_CIT0018","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0149-7634(85)90030-2","article-title":"Exploratory behavior models of anxiety in mice","volume":"9","author":"Crawley","year":"1985","journal-title":"Neurosci Biobehav Rev"},{"key":"key\n\t\t\t\t20170512041426_CIT0019","first-page":"689","article-title":"Animal models relevant to schizophrenia disorders","volume":"2002","author":"Geyer"},{"key":"key\n\t\t\t\t20170512041426_CIT0020","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neulet.2007.01.085","article-title":"D-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro","volume":"417","author":"Sun","year":"2007","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t20170512041426_CIT0021","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuron.2006.09.015","article-title":"Neurobiology of schizophrenia","volume":"52","author":"Ross","year":"2006","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170512041426_CIT0022","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/schbul\/sbm158","article-title":"Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk","volume":"34","author":"Lawrie","year":"2008","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512041426_CIT0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(01)00163-3","article-title":"A review of MRI findings in schizophrenia","volume":"49","author":"Shenton","year":"2001","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512041426_CIT0024","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/sj.mp.4002144","article-title":"Enlargement of the lateral ventricles in mutant DISC1 transgenic mice","volume":"13","author":"Pletnikov","year":"2008","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170512041426_CIT0025","doi-asserted-by":"crossref","first-page":"14501","DOI":"10.1073\/pnas.0704774104","article-title":"Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans","volume":"104","author":"Hikida","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170512041426_CIT0026","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0014-5793(90)80652-Y","article-title":"Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead","volume":"261","author":"Alkondon","year":"1990","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170512041426_CIT0027","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-3940(92)90796-A","article-title":"Age-dependent effects of lead on [3H]MK-801 binding to the NMDA receptor-gated ionophore: in vitro and in vivo studies","volume":"148","author":"Guilarte","year":"1992","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t20170512041426_CIT0028","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/toxsci\/kfs090","article-title":"Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disorders","volume":"127","author":"Stansfield","year":"2012","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170512041426_CIT0029","doi-asserted-by":"crossref","first-page":"e25303","DOI":"10.1371\/journal.pone.0025303","article-title":"Time-lapse imaging reveals symmetric neurogenic cell division of GFAP-expressing progenitors for expansion of postnatal dentate granule neurons","volume":"6","author":"Namba","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170512041426_CIT0030","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1073\/pnas.1012621108","article-title":"Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner","volume":"108","author":"Ramsey","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170512041426_CIT0031","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.earlhumdev.2009.04.006","article-title":"Gender specific differences in neurodevelopmental effects of prenatal exposure to very low-lead levels: the prospective cohort study in three-year olds","volume":"85","author":"Jedrychowski","year":"2009","journal-title":"Early Hum Dev"},{"key":"key\n\t\t\t\t20170512041426_CIT0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2007.08.001","article-title":"New and evolving concepts in the neurotoxicology of lead","volume":"225","author":"White","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"key\n\t\t\t\t20170512041426_CIT0033","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.taap.2011.08.008","article-title":"Sex-based differences in gene expression in hippocampus following postnatal lead exposure","volume":"256","author":"Schneider","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"key\n\t\t\t\t20170512041426_CIT0034","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1289\/ehp.10862","article-title":"Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice","volume":"116","author":"Leasure","year":"2008","journal-title":"Environ Health Perspect"},{"key":"key\n\t\t\t\t20170512041426_CIT0035","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hipo.20780","article-title":"Kalirin-7, an important component of excitatory synapses, is regulated by estradiol in hippocampal neurons","volume":"21","author":"Ma","year":"2011","journal-title":"Hippocampus"},{"key":"key\n\t\t\t\t20170512041426_CIT0036","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1073\/pnas.0409723102","article-title":"Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration","volume":"102","author":"Kim","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170512041426_CIT0037","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1073\/pnas.94.6.2569","article-title":"Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method","volume":"94","author":"Breier","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170512041426_CIT0038","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/10673220902979896","article-title":"A critique of the dopamine hypothesis of schizophrenia and psychosis","volume":"17","author":"Moncrieff","year":"2009","journal-title":"Harv Rev Psychiatry"},{"key":"key\n\t\t\t\t20170512041426_CIT0039","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00213-007-0729-8","article-title":"Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine in postpubertal rats","volume":"192","author":"Abekawa","year":"2007","journal-title":"Psychopharmacology"},{"key":"key\n\t\t\t\t20170512041426_CIT0040","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s002130100800","article-title":"Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review","volume":"156","author":"Weiss","year":"2001","journal-title":"Psychopharmacology"},{"key":"key\n\t\t\t\t20170512041426_CIT0041","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1046\/j.1440-1681.2003.03823.x","article-title":"Deficient prepulse inhibition of acoustic startle in Hooded-Wistar rats compared with Sprague-Dawley rats","volume":"30","author":"Van den Buuse","year":"2003","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key\n\t\t\t\t20170512041426_CIT0042","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0892-0362(99)00042-2","article-title":"Effects of chronic low-level oral lead exposure on prepulse inhibition of acoustic startle in the rat","volume":"22","author":"Commissaris","year":"2000","journal-title":"Neurotoxicol Teratol"},{"key":"key\n\t\t\t\t20170512041426_CIT0043","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.neuropharm.2011.02.003","article-title":"Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model","volume":"62","author":"Pogorelov","year":"2012","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170512041426_CIT0044","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF00330817","article-title":"Neurobehavioral and systemic effects of longterm blood lead-elevation in rats. I. Discrimination learning and open field-behavior","volume":"37","author":"Winneke","year":"1977","journal-title":"Arch Toxicol"}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/40\/3\/575\/16976649\/sbt071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T02:57:14Z","timestamp":1503543434000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-lookup\/doi\/10.1093\/schbul\/sbt071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,28]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,5,28]]},"published-print":{"date-parts":[[2014,5]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbt071","relation":{},"ISSN":["1745-1701","0586-7614"],"issn-type":[{"value":"1745-1701","type":"electronic"},{"value":"0586-7614","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,28]]}}}