{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:21:35Z","timestamp":1792027295753,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1093\/schbul\/sbu052","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T13:22:37Z","timestamp":1397827357000},"page":"963-972","source":"Crossref","is-referenced-by-count":101,"title":["Inflammatory Molecular Signature Associated With Infectious Agents in Psychosis"],"prefix":"10.1093","volume":"40","author":[{"given":"Lindsay N.","family":"Hayes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily G.","family":"Severance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Leek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Gressitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrin","family":"Rohleder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Coughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Markus","family":"Leweke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Yolken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"key":"key\n\t\t\t\t20170512042153_CIT0001","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/schbul\/sbt108","article-title":"Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia","volume":"39","author":"McGrath","year":"2013","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512042153_CIT0002","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/dneu.22024","article-title":"Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism","volume":"72","author":"Brown","year":"2012","journal-title":"Dev Neurobiol"},{"key":"key\n\t\t\t\t20170512042153_CIT0003","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.schres.2012.02.009","article-title":"Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition","volume":"137","author":"Husted","year":"2012","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512042153_CIT0004","doi-asserted-by":"crossref","first-page":":97","DOI":"10.1016\/j.gene.2013.09.110","article-title":"Genetic insight of schizophrenia: past and future perspectives","volume":"535","author":"Singh","year":"2013","journal-title":"Gene"},{"key":"key\n\t\t\t\t20170512042153_CIT0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s00406-004-0481-6","article-title":"Antibodies to infectious agents in individuals with recent onset schizophrenia","volume":"254","author":"Leweke","year":"2004","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"key\n\t\t\t\t20170512042153_CIT0006","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/mp.2008.5","article-title":"Are some cases of psychosis caused by microbial agents? A review of the evidence","volume":"13","author":"Yolken","year":"2008","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170512042153_CIT0007","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bbr.2008.12.022","article-title":"Neural basis of psychosis-related behaviour in the infection model of schizophrenia","volume":"204","author":"Meyer","year":"2009","journal-title":"Behav Brain Res"},{"key":"key\n\t\t\t\t20170512042153_CIT0008","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1126\/science.1228261","article-title":"Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice","volume":"339","author":"Giovanoli","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20170512042153_CIT0009","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2478\/s13380-012-0045-6","article-title":"Prenatal infection, maternal immune activation, and risk for schizophrenia","volume":"3","author":"Canetta","year":"2012","journal-title":"Transl Neurosci"},{"key":"key\n\t\t\t\t20170512042153_CIT0010","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1093\/schbul\/sbt141","article-title":"Inflammation and schizophrenia","volume":"39","author":"Kirkpatrick","year":"2013","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512042153_CIT0011","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.biopsych.2013.09.023","article-title":"The epidemiologic evidence linking autoimmune diseases and psychosis","volume":"75","author":"Benros","year":"2014","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170512042153_CIT0012","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.09.003","article-title":"The environment and susceptibility to schizophrenia","volume":"93","author":"Brown","year":"2011","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t20170512042153_CIT0013","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/schbul\/sbs043","article-title":"Toxoplasma gondii and other risk factors for schizophrenia: an update","volume":"38","author":"Torrey","year":"2012","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512042153_CIT0014","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.schres.2011.10.026","article-title":"Infectious agents associated with schizophrenia: a meta-analysis","volume":"136","author":"Arias","year":"2012","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512042153_CIT0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.schres.2011.01.020","article-title":"Serological evidence of exposure to Herpes Simplex Virus type 1 is associated with cognitive deficits in the CATIE schizophrenia sample","volume":"128","author":"Yolken","year":"2011","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512042153_CIT0016","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1176\/appi.ajp.2011.10101423","article-title":"Progressive gray matter loss and changes in cognitive functioning associated with exposure to herpes simplex virus 1 in schizophrenia: a longitudinal study","volume":"168","author":"Prasad","year":"2011","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20170512042153_CIT0017","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.schres.2008.07.017","article-title":"Antibodies to cytomegalovirus and Herpes Simplex Virus 1 associated with cognitive function in schizophrenia","volume":"106","author":"Shirts","year":"2008","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512042153_CIT0018","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/schbul\/sbt001","article-title":"Pro-\/Anti-inflammatory dysregulation in patients with first episode of psychosis: Toward an integrative inflammatory hypothesis of schizophrenia","volume":"40","author":"Garc\u00eda-Bueno","year":"2014","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512042153_CIT0019","doi-asserted-by":"crossref","first-page":"e78729","DOI":"10.1371\/journal.pone.0078729","article-title":"Distinct molecular phenotypes in male and female schizophrenia patients","volume":"8","author":"Ramsey","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170512042153_CIT0020","article-title":"Identification of subgroups of schizophrenia patients with changes in either immune or growth factor and hormonal pathways","author":"Schwarz","year":"2013","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170512042153_CIT0021","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/mp.2011.42","article-title":"Identification of a biological signature for schizophrenia in serum","volume":"17","author":"Schwarz","year":"2012","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170512042153_CIT0022","doi-asserted-by":"crossref","first-page":"e9166","DOI":"10.1371\/journal.pone.0009166","article-title":"Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections","volume":"5","author":"Domenici","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170512042153_CIT0023","doi-asserted-by":"crossref","first-page":"e756","DOI":"10.1371\/journal.pone.0000756","article-title":"CSF metabolic and proteomic profiles in patients prodromal for psychosis","volume":"2","author":"Huang","year":"2007","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170512042153_CIT0024","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1371\/journal.pmed.0030327","article-title":"Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia","volume":"3","author":"Holmes","year":"2006","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t20170512042153_CIT0025","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","article-title":"Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects","volume":"70","author":"Miller","year":"2011","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170512042153_CIT0026","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/mp.2012.6","article-title":"Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia","volume":"18","author":"Coughlin","year":"2013","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20170512042153_CIT0027","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2009.206","article-title":"Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study","volume":"67","author":"Ruhrmann","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170512042153_CIT0028","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.schres.2010.03.015","article-title":"Probably at-risk, but certainly ill\u2013advocating the introduction of a psychosis spectrum disorder in DSM-V","volume":"120","author":"Ruhrmann","year":"2010","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512042153_CIT0029","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0920-9964(01)00238-9","article-title":"Psychosis treatment prior to psychosis onset: ethical issues","volume":"51","author":"McGlashan","year":"2001","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170512042153_CIT0030","author":"Therneau","year":"2013"},{"key":"key\n\t\t\t\t20170512042153_CIT0031","doi-asserted-by":"crossref","DOI":"10.1007\/b97377","volume-title":"Survival Analysis: Techniques for Censored and Truncated Data","author":"Klein","year":"2003"},{"key":"key\n\t\t\t\t20170512042153_CIT0032","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-3294-8","volume-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau","year":"2000"},{"key":"key\n\t\t\t\t20170512042153_CIT0033","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170512042153_CIT0034","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1080\/135502801753248141","article-title":"Interaction of alpha-2-macroglobulin and HSV-1 during infection of neuronal cells","volume":"7","author":"Alonso","year":"2001","journal-title":"J Neurovirol"},{"key":"key\n\t\t\t\t20170512042153_CIT0035","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1128\/IAI.74.3.1916-1923.2006","article-title":"Screening for Toxoplasma gondii-regulated transcriptional responses in lipopolysaccharide-activated macrophages","volume":"74","author":"Lee","year":"2006","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170512042153_CIT0036","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.1155174","article-title":"Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia","volume":"320","author":"Walsh","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20170512042153_CIT0037","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1093\/ndt\/gfi143","article-title":"\u201cAs time goes by\u201d: angiotensin II-mediated transactivation of the EGF receptor comes of age","volume":"20","author":"Wolf","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"key\n\t\t\t\t20170512042153_CIT0038","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1291\/hypres.28.925","article-title":"Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme\/epidermal growth factor receptor\/extracellular signal-regulated kinases, NAD(P)H oxidase\/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone\/salt-induced hypertensive rats","volume":"28","author":"Nakano","year":"2005","journal-title":"Hypertens Res"},{"key":"key\n\t\t\t\t20170512042153_CIT0039","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1742-2094-5-32","article-title":"Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone","volume":"5","author":"Gold","year":"2008","journal-title":"J Neuroinflammation"},{"key":"key\n\t\t\t\t20170512042153_CIT0040","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20120078","article-title":"Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders","volume":"123","author":"Saavedra","year":"2012","journal-title":"Clin Sci (Lond)"}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T01:07:15Z","timestamp":1597712835000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-lookup\/doi\/10.1093\/schbul\/sbu052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,17]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,4,17]]},"published-print":{"date-parts":[[2014,9]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbu052","relation":{},"ISSN":["1745-1701","0586-7614"],"issn-type":[{"value":"1745-1701","type":"electronic"},{"value":"0586-7614","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4,17]]}}}