{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:18:02Z","timestamp":1783955882272,"version":"3.55.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1093\/schbul\/sbu071","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T04:36:00Z","timestamp":1401856560000},"page":"355-365","source":"Crossref","is-referenced-by-count":36,"title":["Impact of Antipsychotic Treatment on Attention and Motor Learning Systems in First-Episode Schizophrenia"],"prefix":"10.1093","volume":"41","author":[{"given":"Sarah K.","family":"Keedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Weiden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,3]]},"reference":[{"key":"key\n\t\t\t\t20170508190700_CIT0001","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1176\/appi.ajp.161.7.1304","article-title":"Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic study","volume":"161","author":"Gangadhar","year":"2004","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0002","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1001\/archpsyc.62.3.254","article-title":"Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing","volume":"62","author":"Morey","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0003","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biopsycho.2006.01.005","article-title":"Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans","volume":"73","author":"Chudasama","year":"2006","journal-title":"Biol Psychol"},{"key":"key\n\t\t\t\t20170508190700_CIT0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2012.11.028","article-title":"White matter tract abnormalities between rostral middle frontal gyrus, inferior frontal gyrus and striatum in first-episode schizophrenia","volume":"145","author":"Quan","year":"2013","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0005","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.2174\/138161209788957528","article-title":"Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging","volume":"15","author":"Howes","year":"2009","journal-title":"Curr Pharm Des"},{"key":"key\n\t\t\t\t20170508190700_CIT0006","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-3-642-25761-2_2","article-title":"Role of dopamine D2 receptors for antipsychotic activity","volume-title":"Current Antipsychotics","author":"Ginovart","year":"2012"},{"key":"key\n\t\t\t\t20170508190700_CIT0007","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1017\/S0033291708004212","article-title":"Early striatal hypertrophy in first-episode psychosis within 3 weeks of initiating antipsychotic drug treatment","volume":"39","author":"Chua","year":"2009","journal-title":"Psychol Med"},{"key":"key\n\t\t\t\t20170508190700_CIT0008","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/schbul\/sbn009","article-title":"Cortical dopamine D2\/D3 receptors are a common site of action for antipsychotic drugs\u2013an original patient data meta-analysis of the SPECT and PET in vivo receptor imaging literature","volume":"35","author":"Stone","year":"2009","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170508190700_CIT0009","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/jcp.0b013e3180d0a6d4","article-title":"Early use of clozapine for poorly responding first-episode psychosis","volume":"27","author":"Agid","year":"2007","journal-title":"J Clin Psychopharmacol"},{"key":"key\n\t\t\t\t20170508190700_CIT0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pscychresns.2008.06.003","article-title":"An fMRI study of visual attention and sensorimotor function before and after antipsychotic treatment in first-episode schizophrenia","volume":"172","author":"Keedy","year":"2009","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0011","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archpsyc.63.11.1189","article-title":"Adverse effects of risperidone on spatial working memory in first-episode schizophrenia","volume":"63","author":"Reilly","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0012","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/npp.2008.79","article-title":"Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophrenia","volume":"34","author":"Harris","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20170508190700_CIT0013","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.biopsych.2012.02.007","article-title":"Alterations of the brain reward system in antipsychotic na\u00efve schizophrenia patients","volume":"71","author":"Nielsen","year":"2012","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0014","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1176\/appi.ajp.162.12.2322","article-title":"Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment","volume":"162","author":"Snitz","year":"2005","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0015","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1152\/jn.1996.75.1.454","article-title":"Positron emission tomography study of voluntary saccadic eye movements and spatial working memory","volume":"75","author":"Sweeney","year":"1996","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170508190700_CIT0016","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bandc.2008.08.017","article-title":"Neurophysiology and neuroanatomy of reflexive and voluntary saccades in non-human primates","volume":"68","author":"Johnston","year":"2008","journal-title":"Brain Cogn"},{"key":"key\n\t\t\t\t20170508190700_CIT0017","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/cercor\/bhi073","article-title":"Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems","volume":"15","author":"Sim\u00f3","year":"2005","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170508190700_CIT0018","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bandc.2008.08.016","article-title":"Neurophysiology and neuroanatomy of reflexive and volitional saccades: evidence from studies of humans","volume":"68","author":"McDowell","year":"2008","journal-title":"Brain Cogn"},{"key":"key\n\t\t\t\t20170508190700_CIT0019","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biopsych.2004.10.024","article-title":"Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia","volume":"57","author":"Reilly","year":"2005","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0020","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.biopsych.2007.11.009","article-title":"Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia","volume":"63","author":"Reilly","year":"2008","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0021","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/cercor\/8.1.40","article-title":"Dorsal cortical regions subserving visually guided saccades in humans: an fMRI study","volume":"8","author":"Luna","year":"1998","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170508190700_CIT0022","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/jnnp.72.1.106","article-title":"Immediate and delayed effects of risperidone on cerebral metabolism in neuroleptic naive schizophrenic patients: correlations with symptom change","volume":"72","author":"Ngan","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0023","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1176\/appi.ajp.162.10.1849","article-title":"fMRI study of maintenance and manipulation processes within working memory in first-episode schizophrenia","volume":"162","author":"Tan","year":"2005","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0024","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition","author":"First","year":"2002"},{"key":"key\n\t\t\t\t20170508190700_CIT0025","volume-title":"The Wide Range Achievement Test: Manual","author":"Wilkinson","year":"1993","edition":"3"},{"key":"key\n\t\t\t\t20170508190700_CIT0026","volume-title":"Four-factor Index of Social Status","author":"Hollingshead","year":"1975"},{"key":"key\n\t\t\t\t20170508190700_CIT0027","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170508190700_CIT0028","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0029","first-page":"13","article-title":"The neurobiology of saccadic eye movements. Metrics","volume":"3","author":"Becker","year":"1989","journal-title":"Rev Oculomotor Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0030","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput Biomed Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0031","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pscychresns.2006.01.003","article-title":"Functional magnetic resonance imaging studies of eye movements in first episode schizophrenia: smooth pursuit, visually guided saccades and the oculomotor delayed response task","volume":"146","author":"Keedy","year":"2006","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0032","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.biopsych.2009.08.040","article-title":"Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs","volume":"67","author":"Andreasen","year":"2010","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0033","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0165-1781(91)90065-W","article-title":"Relationships between medication treatments and neuropsychological test performance in schizophrenia","volume":"37","author":"Sweeney","year":"1991","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0034","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1523\/JNEUROSCI.18-04-01613.1998","article-title":"D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat","volume":"18","author":"Seamans","year":"1998","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170508190700_CIT0035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/sj.npp.1301176","article-title":"D1 and D2 receptor antagonist injections in the prefrontal cortex selectively impair spatial learning in mice","volume":"32","author":"Rinaldi","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20170508190700_CIT0036","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/cercor\/bhm038","article-title":"Brain and behavior: a task-dependent eye movement study","volume":"18","author":"Burke","year":"2008","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170508190700_CIT0037","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1162\/jocn.2008.21173","article-title":"Sources of top\u2013down control in visual search","volume":"21","author":"Weidner","year":"2009","journal-title":"J Cogn Neurosci"},{"key":"key\n\t\t\t\t20170508190700_CIT0038","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1080\/13506280500196142","article-title":"Neural correlates of visual dimension weighting","volume":"14","author":"Pollmann","year":"2006","journal-title":"Vis Cogn"},{"key":"key\n\t\t\t\t20170508190700_CIT0039","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1006\/nimg.2000.0742","article-title":"Stimulus-response incompatibility activates cortex proximate to three eye fields","volume":"13","author":"Merriam","year":"2001","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170508190700_CIT0040","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2007.03.023","article-title":"An effect of context on saccade-related behavior and brain activity","volume":"36","author":"Dyckman","year":"2007","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20170508190700_CIT0041","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/WNR.0b013e3281e72ce7","article-title":"Prefrontal cortex is involved in internal decision of forthcoming saccades","volume":"18","author":"Milea","year":"2007","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t20170508190700_CIT0042","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archgenpsychiatry.2010.84","article-title":"Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by \u201cresting state\u201d functional magnetic resonance imaging","volume":"67","author":"Lui","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0043","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.neuron.2006.05.010","article-title":"Changes in visual receptive fields with microstimulation of frontal cortex","volume":"50","author":"Armstrong","year":"2006","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170508190700_CIT0044","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuron.2007.05.019","article-title":"Brain states: top-down influences in sensory processing","volume":"54","author":"Gilbert","year":"2007","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170508190700_CIT0045","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pscychresns.2011.06.011","article-title":"Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis: implications for pursuit eye tracking","volume":"194","author":"Lencer","year":"2011","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0046","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archpsyc.59.8.696","article-title":"Sensory information processing in neuroleptic-naive first-episode schizophrenic patients: a functional magnetic resonance imaging study","volume":"59","author":"Braus","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0047","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0006-3223(01)01204-5","article-title":"Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects","volume":"51","author":"McDowell","year":"2002","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0048","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0006-3223(02)01421-X","article-title":"The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: a comparison between the neuroleptic-na\u00efve and medicated states","volume":"52","author":"Corson","year":"2002","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0049","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pscychresns.2009.04.007","article-title":"The effect of clozapine on regional cerebral blood flow and brain metabolite ratios in schizophrenia: relationship with treatment response","volume":"174","author":"Ertugrul","year":"2009","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1469-8986.1996.tb02112.x","article-title":"Timing and amplitude of saccades during predictive saccadic tracking in schizophrenia","volume":"33","author":"McDowell","year":"1996","journal-title":"Psychophysiology"},{"key":"key\n\t\t\t\t20170508190700_CIT0051","doi-asserted-by":"crossref","first-page":"B81","DOI":"10.1016\/S0010-0277(98)00052-3","article-title":"Predictive saccade behavior is enhanced in schizophrenia","volume":"68","author":"Karoumi","year":"1998","journal-title":"Cognition"},{"key":"key\n\t\t\t\t20170508190700_CIT0052","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.psychres.2005.08.020","article-title":"Evidence from increased anticipation of predictive saccades for a dysfunction of fronto-striatal circuits in obsessive-compulsive disorder","volume":"143","author":"Spengler","year":"2006","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20170508190700_CIT0053","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1177\/0269881111409265","article-title":"Increased prefrontal cortical D 1 receptors in drug naive patients with schizophrenia: a PET study with [\u00b9\u00b9C]NNC112","volume":"26","author":"Abi-Dargham","year":"2012","journal-title":"J Psychopharmacol"},{"key":"key\n\t\t\t\t20170508190700_CIT0054","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1017\/S0033291700033390","article-title":"Saccadic abnormalities in psychotic patients. II. The role of neuroleptic treatment","volume":"25","author":"Crawford","year":"1995","journal-title":"Psychol Med"},{"key":"key\n\t\t\t\t20170508190700_CIT0055","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0006-3223(91)90234-D","article-title":"Maladaptive anticipatory saccades in schizophrenia","volume":"30","author":"Hommer","year":"1991","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0056","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.biopsych.2006.10.031","article-title":"Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia","volume":"62","author":"Reilly","year":"2007","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170508190700_CIT0057","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00213-004-1793-y","article-title":"Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction","volume":"174","author":"Goldman-Rakic","year":"2004","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article\/41\/2\/355\/2526085\/Impact-of-Antipsychotic-Treatment-on-Attention-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T07:34:53Z","timestamp":1565508893000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article-lookup\/doi\/10.1093\/schbul\/sbu071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,3]]},"references-count":57,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,6,3]]},"published-print":{"date-parts":[[2015,3]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbu071","relation":{},"ISSN":["1745-1701","0586-7614"],"issn-type":[{"value":"1745-1701","type":"electronic"},{"value":"0586-7614","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6,3]]}}}