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However, alterations in structure\u2013function coupling after treatment remain unknown. We performed diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging in 42 drug-naive first-episode schizophrenia patients (FESP) both at baseline and after 8-weeks risperidone monotherapy, and in 38 healthy volunteers. Independent component analysis was used to assess voxel-wise DMN synchrony. A 3-step procedure was used to trace fiber paths between DMN components. Structure\u2013function couplings were assessed by Pearson\u2019s correlations between mean fractional anisotropy and temporal correlation coefficients in major tracts of DMN. Pretreatment, FESP showed impaired functional connectivity in posterior cingulate cortex\/precuneus (PCC\/PCUN) and medial prefrontal cortex (mPFC), but no abnormalities in fibers connecting DMN components. After treatment, there were significant increases in functional connectivities of PCC\/PCUN. Increases in functional connectivity between PCC\/PCUN and mPFC correlated with improvement in positive symptoms. The structure\u2013function coupling in tracts connecting PCC\/PCUN and bilateral medial temporal lobes decreased after treatment. No alterations in DMN fiber integrity were detected. This combination of functional and anatomical findings in FESP contributes novel evidence related to neurobehavioral treatment effects. Increased functional connectivities between PCC\/PCUN and mPFC may be treatment response biomarkers for positive symptoms. Increases in functional connectivities, no alterations in fiber integrity, combined with decreases in structural\u2013functional coupling, suggest that DMN connectivities may be dissociated by modality after 8-week treatment. Major limitations of this study, however, include lack of repeat scans in healthy volunteers and control group of patients taking placebo or comparator antipsychotics.<\/jats:p>","DOI":"10.1093\/schbul\/sby175","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T16:02:11Z","timestamp":1542297731000},"page":"1309-1318","source":"Crossref","is-referenced-by-count":47,"title":["A Dissociation in Effects of Risperidone Monotherapy on Functional and Anatomical Connectivity Within the Default Mode Network"],"prefix":"10.1093","volume":"45","author":[{"given":"Xiaofen","family":"Zong","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China"},{"name":"Division of Molecular Imaging and Neuropathology, Columbia University and New York State Psychiatric Institute, New York, 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Columbia University and New York State Psychiatric Institute, New York, NY"},{"name":"Department of Psychiatry, Columbia University, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaohua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongchang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxian","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deen","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Mental Health Institute of Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center on Mental Disorders (Xiangya), National Technology Institute on Mental Disorders, Changsha, Hunan, China"},{"name":"Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, 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